Design, synthesis, and anti-aging effect evaluation of urolithin B and its amide derivatives on nematode Caenorhabditis elegans

Chen, Xi; Feng, Xingyu; Kong, Xiangming; Wang, Hecheng; Liu, Tianwen; Tang, Long; Zhuang, Zanyong

doi:10.1007/s00044-023-03056-4

Med Chem Res

2023

DOI: 10.1007/s00044-023-03056-4

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Design, synthesis, and anti-aging effect evaluation of urolithin B and its amide derivatives on nematode Caenorhabditis elegans

Xi Chen

Xingyu Feng

Xiangming Kong³

et al.

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“…Chen et al designed and synthesized an amide derivative of urolithin B and verified its anti-aging and biosafety using C. elegans. The results showed that 116 had the best anti-aging activity among all derivatives, and the compound had good biosafety [123].…”

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Natural Products–Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry

Chen,

Guo,

Quan

et al. 2023

Molecules

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Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its derivatives are biologically active compounds. References have been downloaded through Web of Science, PubMed, Science Direct, and SciFinder Scholar. The structure, biological activity, and mechanism of natural product derivatives containing pyrazine fragments reported from 2000 to September 2023 were reviewed. Publications reporting only the chemistry of pyrazine derivatives are beyond the scope of this review and have not been included. The results of research work show that pyrazine-modified natural product derivatives have a wide range of biological activities, including anti-inflammatory, anticancer, antibacterial, antiparasitic, and antioxidant activities. Many of these derivatives exhibit stronger pharmacodynamic activity and less toxicity than their parent compounds. This review has a certain reference value for the development of heterocyclic compounds, especially pyrazine natural product derivatives.

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confidence: 99%

Natural Products–Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry

Chen,

Guo,

Quan

et al. 2023

Molecules

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Design, synthesis, and anti-aging effect evaluation of urolithin B and its amide derivatives on nematode Caenorhabditis elegans

Cited by 1 publication

References 30 publications

Natural Products–Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry

Natural Products–Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry

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