Efficient Analysis of Non-Polar Environmental Contaminants by MALDI-TOF MS with Graphene as Matrix

Zhang, Jing; Dong, Xiaoli; Cheng, Jiujun; Li, Jinghong; Wang, Yinsheng

doi:10.1007/s13361-011-0143-7

Cited by 69 publications

(45 citation statements)

References 24 publications

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“…Since then, other articles have described the use of graphene as a matrix [1,[3][4][5], and the present work is the first study where graphene is used as a MALDI adjuvant improving ionization rate with a stabilizing effect that reduces the rate of fragmentation and gives rise to a better detection of phosphorylated peptides and a higher number of peaks detected in the analysis of complex samples. The enhancement of the signal with the combination of graphene/CHCA is especially useful in the case of complex samples where more peaks are detected, mainly in the high mass range of the spectra.…”

Section: Discussionmentioning

confidence: 90%

“…There are very few published papers in which graphene is used as matrix for MALDI-TOF and all of them employed mass spectrometers equipped with a laser emitting at 337nm (pulsed nitrogen laser) [8] or 355nm (Nd:YAG laser) [3,8]; both wavelengths are far from the maximum absorption wavelength of graphene (270nm) [9]. In these cases, the processes involved in the ionization of the molecules must be related to surface electronic charge events rather than a resonant absorption of light, as is the case with traditional matrices used in MALDI-TOF mass spectrometers.…”

Section: Discussionmentioning

confidence: 99%

“…I n the last few years, the use of graphene as a new MALDI matrix for the analysis of low molecular weight molecules has been extensively described [1][2][3][4][5][6]. The main advantages of this matrix are related to (1) the absence of interfering peaks in the spectra at low mass range, usually visible when using traditional matrices [7], and (2) an attenuation of analyte fragmentation [8], which could reduce the complexity of the spectra at higher signal intensities.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides

Rodríguez

Palacios

Fajardo

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. This is the first study where graphene is used as a MALDI adjuvant in combination with the traditional matrix α-cyano-4-hydroxycinnamic acid (CHCA) to improve the signal intensity of peptide samples. Use of this amended matrix not only leads to increased signals but also to a higher number of peaks detected in complex samples. Additionally, the use of graphene has a stabilizing effect that can also be exploited to improve the detection of easily cleavable molecules.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides

Rodríguez

Palacios

Fajardo

et al. 2015

J. Am. Soc. Mass Spectrom.

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“…In addition, pure graphene as a matrix has also been successfully applied to the LDI MS analysis of polymers [67], drugs [68], biomolecules [69,70], organic pollutants [71][72][73], fatty acids [69,74], active ingredients in herbs [75][76][77], metals and metal-organic complexes [78,79], and glycan [80].…”

Section: Graphenementioning

confidence: 99%

Recent progress in application of carbon nanomaterials in laser desorption/ionization mass spectrometry

et al. 2016

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Carbon nanomaterials have attracted great interest over past decades owing to their unique physical properties, versatile functionalization chemistry, and biological compatibility. In this article, we review recent progress in application of carbon nanomaterials in laser desorption/ionization mass spectrometry (LDI MS). Various types of carbon nanomaterials, including fullerenes, carbon nanotubes, graphene, carbon nanodots, nanodiamond, nanofibers, nanohorns, and their derivative forms, are involved. The applications of these materials as new matrices or probes in matrix-assisted or surface-enhanced laser desorption/ ionization mass spectrometry (MALDI or SELDI MS) are discussed. Finally, we summarize current challenges and give our perspectives on the future of applications of carbon nanomaterials in LDI MS.

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“…Use as MALDI matrix is a very interesting application aspect for G. [16][17][18][19][20][21][22][23][24] An ideal MALDI matrix should have strong energy absorption and transfer capability. In this regard, G is a good candidate due to its fast charge carrier mobility [25] and universal and frequency-independent optical absorption properties.…”

mentioning

confidence: 99%

Mildly Oxidized Graphene: Facile Synthesis, Characterization, and Application as a Matrix in MALDI Mass Spectrometry

Liu

Cheng

Jiang

2013

Chemistry A European J

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Graphene (G) is a new allotropic member of carbon with a unique two-dimensional and one-atom-thick sheet structure. It has attracted tremendous research interest in both academic and industrial areas due to its exceptional physical and chemical properties. [1][2][3] However, a serious problem in synthesis and application of G is aggregation. Due to the strong hydrophobic nature of G, G sheets have a strong tendency to aggregate to G clusters or even restack to graphite particles through van der Waals interactions. The resulting G agglomerates are very hard and insoluble in water or organic solvents, making further processing difficult. Since most of the exceptional properties of G can only be achieved with individual sheets, prevention of aggregation of G sheets is of particular importance for its applications.Aggregation of G can be reduced by using stabilizers. [4][5][6] However, attachment of foreign molecules onto G sheets may cause an adverse impact on the applications. As an alternative, graphene oxide (GO) has an excellent water dispersibility and has been used as a substitute for G in many applications. [3] GO is usually obtained by exfoliation of graphite oxide, [7][8] which can be synthesized from graphite. [9] However, the heavy oxidation during the synthesis can severely damage the large delocalized p-electron system of G and cause many imperfections and defects in the GO sheets. Thus, the unique electronic and optical absorption properties of G are seriously compromised in GO. Li et al. [10] reported the preparation of a processable aqueous dispersion of chemically converted G from GO; however, the obtained G dispersion was only stable under basic conditions and the reductant was difficult to remove from the dispersion. Therefore, facile and scalable methods for the synthesis of low-defect, well-dispersed, and clean G sheets are still urgently desired. Inspired by GO, we hypothesized that controlling the oxidation degree of G may provide a feasible approach for this purpose. However, although significant efforts have been made on developing synthetic strategies of G, little attention has been paid to controlling the oxidation degree of G. [11][12] Herein, we report a very simple method for the synthesis of mildly oxidized graphene by oxidizing chemically converted G with diluted nitric acid (2 m; Scheme 1A). We aimed to find a facile approach to prevent the aggregation of G sheets while maintaining the G structure as intact as possible. To distinguish from GO, the produced material is called acid-oxidized graphene (AOG). The AOG showed good dispersibility in water (up to 1 mg mL À1 ). Meanwhile, unlike GO (Scheme 1B), the main framework of G was not disrupted, and thus most of the exceptional properties of G can be maintained. Therefore, the AOG combines the advantages of G and GO while avoiding their disadvantages. Furthermore, the AOG contains no stabilizer molecules and can be highly pure, which is very favorable for its applications.We found that the AOG aqueous dispersion was rather stable. Eve...

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Efficient Analysis of Non-Polar Environmental Contaminants by MALDI-TOF MS with Graphene as Matrix

Cited by 69 publications

References 24 publications

Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides

Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides

Recent progress in application of carbon nanomaterials in laser desorption/ionization mass spectrometry

Mildly Oxidized Graphene: Facile Synthesis, Characterization, and Application as a Matrix in MALDI Mass Spectrometry

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