Recent progress in application of carbon nanomaterials in laser desorption/ionization mass spectrometry

Wang, Jing; Liu, Qian; Liang, Yong; Jiang, Guibin

doi:10.1007/s00216-015-9255-4

Cited by 58 publications

(24 citation statements)

References 127 publications

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“…The proficiency of these materials can also be enhanced by using binary matrices (e.g., carbon dots/9-aminoacridine and α-cyano-4-hydroxycinnamic ac-id/graphene) which improved detection sensitivity and shot-to-shot reproducibility by producing more homogeneous co-crystallization matrix layers [21, 27]. Carbon nanomaterials have also been demonstrated to be an excellent class of sorbent materials for extraction and enrichment of a variety biological molecules such as amino acids, polyamines, peptides, steroids, DNA and carbohydrates [22, 25, 28–30]. …”

Section: Introductionmentioning

confidence: 99%

Carbon Nanoparticles and Graphene Nanosheets as MALDI Matrices in Glycomics: a New Approach to Improve Glycan Profiling in Biological Samples

Banazadeh

Peng

Veillon

et al. 2018

J. Am. Soc. Mass Spectrom.

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Glycomics continues to be a highly dynamic and interesting research area due to the need to comprehensively understand the biological attributes of glycosylation in many important biological functions such as the immune response, cell development, cell differentiation/adhesion, and host-pathogen interactions. Although matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) has proven to be suitable for glycomic profiling studies, there is a need for improved sensitivity in the detection of native glycans, which ionize inefficiently. In this study, we investigated the efficiencies of graphene nanosheets (GNs) and carbon nanoparticles (CNPs) as MALDI matrices and co-matrices in glycan profiling. Our results indicated an enhancement of signal intensity by several orders of magnitude upon using GNs and CNPs in MALDI analysis of N-glycans derived from a variety of biological samples. Interestingly, increasing the amounts of CNPs and GNs improved not only the signal intensities but also prompted in-source decay (ISD) fragmentations, which produced extensive glycosidic and cross-ring cleavages. Our results indicated that the extent of ISD fragmentation could be modulated by CNP and GN concentrations, to obtain MS and pseudo-MS spectra. The results for glycan profiling in high salt solutions confirmed high salt-tolerance capacities for both CNPs and GNs. Finally, the results showed that by using CNPs and GNs as co-matrices, DHB crystal formation was more homogeneous which improved shot-to-shot reproducibility and sensitivity. Graphical Abstract ᅟ.

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Section: Introductionmentioning

confidence: 99%

Carbon Nanoparticles and Graphene Nanosheets as MALDI Matrices in Glycomics: a New Approach to Improve Glycan Profiling in Biological Samples

Banazadeh

Peng

Veillon

et al. 2018

J. Am. Soc. Mass Spectrom.

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“…Furthermore, alkali metal addition ions such as [M+K] + or [M+Na] + of biomolecules (M) were sometimes introduced to ionization processes and suppressed mass spectrometric signals. Very recently, for this, the use of carbon nanomaterials (graphite, graphene, carbon nanotubes, carbon black, and polymeric nanofibers) as SALDI substrates has been rapidly growing in SALDI applications [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. These carbon forms are different in an optical absorption property.…”

Section: Introductionmentioning

confidence: 99%

Atmospheric Pressure Plasma-Treated Carbon Nanowalls’ Surface-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (CNW-SALDI-MS)

Ohta

Ito

Ishikawa

et al. 2019

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Carbon nanowalls (CNWs), vertically standing highly crystallizing graphene sheets, were used in the application of a surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF-MS). The CNW substrates solved the issues on interferences of matrix molecules and alkali metal addition ions in low-weight molecule detection. Before SALDI sample preparations, the hydrophobic CNW was treated by atmospheric pressure plasma for exposing hydrophilicity to the CNWs’ surface. Detection of water soluble amino acids, arginine, was demonstrated.

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“…Nanomaterials have been widely developed as efficient assisted matrices for LDI profiling small molecules [15,16,17,18]. The history of nanomaterials as matrix for MALDI can be traced to the 1980s, in which cobalt nanopowder mixed with glycerol in organic solvent (e.g., ethanol and acetone) were used to ionization of synthetic polymers and proteins.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Yang

et al. 2017

Nanomaterials

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Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds.

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Recent progress in application of carbon nanomaterials in laser desorption/ionization mass spectrometry

Cited by 58 publications

References 127 publications

Carbon Nanoparticles and Graphene Nanosheets as MALDI Matrices in Glycomics: a New Approach to Improve Glycan Profiling in Biological Samples

Carbon Nanoparticles and Graphene Nanosheets as MALDI Matrices in Glycomics: a New Approach to Improve Glycan Profiling in Biological Samples

Atmospheric Pressure Plasma-Treated Carbon Nanowalls’ Surface-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (CNW-SALDI-MS)

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

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