Efficient amelioration of carbon tetrachloride induced toxicity in isolated rat hepatocytes by Syzygium cumini Skeels extract

Veigas, Jyothi M.; Shrivasthava, Richa; Neelwarne, Bhagyalakshmi

doi:10.1016/j.tiv.2008.04.015

Cited by 33 publications

(22 citation statements)

References 34 publications

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“…66 The fruit extract of Jamun has also been reported to protect rat hepatocytes against carbon tetrachloride-induced toxicity in vitro. 30 Similarly, the administration of ethanol extract of Jamun fruit pulp for 8 consecutive days prior to paracetamol treatment has been shown to protect rats against paracetamol-induced hepatotoxicity. 67 The Jamun fruit extract has also been found to reduce bile duct ligation-induced damage to hepatocytes, hepatic fibrosis and macrophage infiltration by reducing lipid peroxidation and mRNA expression of intracellular adhesion molecule (Icam-1) and Chemokine (C-X-C motif) ligand 2 (Cxcl2 genes).…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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Plants have been employed as medicine since time immemorial, and there has been a recent resurgence in the use of plants as medicines due to their little or no toxicity at the doses used for treatment of different ailments. This review discusses in detail the phytochemical and pharmacological activities of Jamun (Syzygium cumini), a tree belonging to family Myrtaceae, which has been credited with several medicinal properties in the traditional system of medicine, the Ayurveda. The different properties attributed to Jamun are sweet, sour, astringent, acrid, refrigerant, carminative, diuretic, and digestive. Research and practical use in traditional medicinal systems have found Jamun to be effective in treating leucorrhoea, gastric disorders, fever, diabetes, piles, stomachache, wounds, and dental, digestive and skin disorders. Some compounds in Jamun have antioxidant, antimicrobial, antiallergic, antidiabetic, antihyperlipidemic, anticancer, gastroprotective, hepatoprotective, cardioprotective and radioprotective activity. Finally, Jamun has been found to contain phytochemicals including anthroquinones, alkaloids, catechins, flavonoids, glycosides, steroids, phenols, tannins, saponins and cardiac glycosides. The diverse activities of Jamun may be due to its abilities to scavenge free radicals, increase antioxidant status of cells by increasing glutathione, glutathione peroxidase, catalase and/or superoxide dismutase, and to attenuate lipid peroxidation. In addition, it also suppresses the transcription of peroxisome proliferator-activated receptor, Nuclear factor kappa B, cyclooxygenase, inducible nitric oxide synthase, tumor necrosis factor alpha and other proinflammatory cytokines, accompanied by the up-regulation of nuclear factor erythroid 2-related factor 2 transcription, which is involved in regulating the antioxidant status of the cells.

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Section: Hepatoprotective Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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“…For this purpose, blood was centifuge at 1000g, 10 minutes for 4 o C. Plasma was used in cell culture experiments as detailed below. and PP + SC (400 ppm) [17].…”

Section: Collection Of Plasma Preeclamptic Patientsmentioning

confidence: 99%

Syzygium Cumini Reduces Vcam-1 and Icam-1 Expression in Endothelial Cells Induced by Plasma from Preeclamptic Patients

Wulandari¹,

Winarsih²,

Baktiyani³

2016

Med-Science

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The present study sought to investigate a role for Syzygium cumini on VCAM-1 and ICAM-1 expression in endothelial cells induced by plasma from preeclamptic patients. Endothelial cells were obtained from human umbilical vascular endothelial cells. At confluency, endothelial cells were divided into five groups, which included control (untreated), endothelial cells exposed to 2% plasma from preeclamptic patients (PP), endothelial cells exposed to PP in the presence of ethanolic extract of Syzygium cumini (PP + SC

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“…There are several studies, in normal cells and tissues, in which it was demonstrated that anthocyanins, probably involving some protein kinases, modulate the activity of some GSHdependent enzymes, thus ameliorating the antioxidant response (Hou et al, 2010;Suda et al, 2008;Veigas et al, 2008). GSSG formed intracellularly is continuously reduced to GSH by the activity of GR.…”

Section: Gsh Role In Apoptosismentioning

confidence: 99%

Dietary Anthocyanins: Impact on Colorectal Cancer and Mechanisms of Action

Tramer¹,

Može²,

Ademosun³

et al. 2012

Colorectal Cancer - From Prevention to Patient Care

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Efficient amelioration of carbon tetrachloride induced toxicity in isolated rat hepatocytes by Syzygium cumini Skeels extract

Cited by 33 publications

References 34 publications

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Syzygium Cumini Reduces Vcam-1 and Icam-1 Expression in Endothelial Cells Induced by Plasma from Preeclamptic Patients

Dietary Anthocyanins: Impact on Colorectal Cancer and Mechanisms of Action

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