Dietary Anthocyanins: Impact on Colorectal Cancer and Mechanisms of Action

Tramer, Federica; Može, Špela; Ademosun, Ayokunle O.; Passamonti, Sabina; Čvorović, Jovana

doi:10.5772/27678

Cited by 6 publications

(4 citation statements)

References 222 publications

(207 reference statements)

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“…Further, several studies also indicate that anthocyanins are able to inhibit the growth of different cancer cells, suggesting their possible role as chemopreventive agents [35, 36]. In particular, it has been suggested that the inhibitory effects of anthocyanin-rich fruit and vegetable extracts are based on the concentration rather than the composition of anthocyanins [37–39].…”

Section: Resultsmentioning

confidence: 99%

Red Chicory (Cichorium intybusL. cultivar) as a Potential Source of Antioxidant Anthocyanins for Intestinal Health

D'Evoli

Morroni

Lombardi‐Boccia

et al. 2013

Oxidative Medicine and Cellular Longevity

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Fruit- and vegetable-derived foods have become a very significant source of nutraceutical phytochemicals. Among vegetables, red chicory (Cichorium Intybus L. cultivar) has gained attention for its content of phenolic compounds, such as the anthocyanins. In this study, we evaluated the nutraceutical effects, in terms of antioxidant, cytoprotective, and antiproliferative activities, of extracts of the whole leaf or only the red part of the leaf of Treviso red chicory (a typical Italian red leafy plant) in various intestinal models, such as Caco-2 cells, differentiated in normal intestinal epithelia and undifferentiated Caco-2 cells. The results show that the whole leaf of red chicory can represent a good source of phytochemicals in terms of total phenolics and anthocyanins as well as the ability of these phytochemicals to exert antioxidant and cytoprotective effects in differentiated Caco-2 cells and antiproliferative effects in undifferentiated Caco-2 cells. Interestingly, compared to red chicory whole leaf extracts, the red part of leaf extracts had a significantly higher content of both total phenolics and anthocyanins. The same extracts effectively corresponded to an increase of antioxidant, cytoprotective, and antiproliferative activities. Taken together, these findings suggest that the red part of the leaf of Treviso red chicory with a high content of antioxidant anthocyanins could be interesting for development of new food supplements to improve intestinal health.

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Section: Resultsmentioning

confidence: 99%

Red Chicory (Cichorium intybusL. cultivar) as a Potential Source of Antioxidant Anthocyanins for Intestinal Health

D'Evoli

Morroni

Lombardi‐Boccia

et al. 2013

Oxidative Medicine and Cellular Longevity

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“…They also seem to have anti-aging and anti-free radical effects (31)(32)(33). Furthermore, anthocyanins derived from sweet potato were shown to inhibit the development of CRC (34). This compound was able to induce anti-proliferative and apoptotic mechanisms as well as cell cycle arrest both in vivo and in vitro (31).…”

Section: Antioxidantsmentioning

confidence: 99%

Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants

Cetta

Mazzola

Rappa

et al. 2017

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One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.

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“…Dietary agents such as anthocyanins have been explored for their chemopreventive effects against colon cancer [26]. In vitro data obtained in this research provides information for the future application of blue corn extract as a chemopreventive agent in colon cancer.…”

Section: Natural Products and Cancer Drug Discoverymentioning

confidence: 89%

Chemical, Antioxidant, and Cytotoxic Properties of Native Blue Corn Extract

Guzmán-Gerónimo¹,

Aparicio²,

García-Barradas³

et al. 2017

Natural Products and Cancer Drug Discovery

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In recent years, natural products such as dietary phytoconstituents have been the focus of scientific studies for cancer prevention. Among these are polyphenols, which have shown anticancer properties. Pigmented cereals such as blue maize are a rich source of polyphenols such as anthocyanins. Therefore, the aim of this work is to determine the chemical composition and cytotoxic activity of blue maize extract in several cancer cell lines. The total polyphenol content, total anthocyanins, and antioxidant activity of 16 blue corn samples from the Mixteco race were analyzed. From these, the sample with the highest content of polyphenols, anthocyanins, and antioxidant activity was selected and its anthocyanin fraction was isolated using an amberlite column and analyzed by means of HPLC-ESI-MS. The total polyphenol content ranged from 142.8 to 203.2 mg GAE/100g. The total anthocyanin contents varied between 19.02 and 66.92 mg C3G/100g. The antioxidant activity ranged from 18.5 to 27.8 µmol TE/g. The anthocyanin profile showed eight different compounds, mainly acylated anthocyanins. Cytotoxicity of blue corn extract on cancer cell lines was determined at concentrations of 100 and 500 µg/mL using the SRB assay. A cytotoxic effect was mainly observed on SKLU-1 and HTC-15 cell lines.

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Dietary Anthocyanins: Impact on Colorectal Cancer and Mechanisms of Action

Cited by 6 publications

References 222 publications

Red Chicory (Cichorium intybusL. cultivar) as a Potential Source of Antioxidant Anthocyanins for Intestinal Health

Red Chicory (Cichorium intybusL. cultivar) as a Potential Source of Antioxidant Anthocyanins for Intestinal Health

Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants

Chemical, Antioxidant, and Cytotoxic Properties of Native Blue Corn Extract

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