Efficient 4 + 1 Syntheses of Highly Functionalized Cyclopentenes

Synthesis and properties of carboxy-substituted half-sandwich ruthenium complexes with chelating bisphosphine ligands (η5-C5H4CO2H)Ru(η2-L)X (X=I, H)

“…Eventually we made the bis(triphenylphosphine) ruthenium chloride complex 3 by treating RuCl 2 (PPh 3 ) 3 (1) with Li[C 5 H 4 CO 2 t-Bu] (2) [11] in refluxing THF (Scheme 1). Treating 3 with dppe in refluxing toluene replaced the triphenylphosphines with dppe, giving the t-butyl ester chloride complex 4a.…”

“…Sometimes this splitting is too small to be observable; in these cases the A and B resonances are reported as singlets. (2) n-BuLi (28.8 mL, 1.6 M in hexanes, 46.1 mmol) was added slowly to t-butoxycarbonylcyclopentadiene [11] (6.66 g, 40.1 mmol) in Et 2 O at À78°C. The mixture was warmed to room temperature and stirred for 1 h. Hexanes were added until a white precipitate formed.…”

[(Cp-R)M(CO)3] (M= Re or 99mTc) Conjugates for Theranostic Receptor Targeting

“…Many different substituents have been described in literature. [29][30][31][32][33][34][35] However, reports for coupling biologically active targeting vectors are comparably scarce. Being part of the spacer between the chelator and the biovector, the functional group attached to Cp is of great importance for a bifunctional chelator (BFC).…”

Synthesis of Paramagnetic Carbo-and Heterocycles

“…The dibromo compound 15, available from diene 3 by 1,4-addition, 14 was converted to paramagnetic cyclopentene compound 16 by double alkylation of methyl phenylsulfonylacetate. 28 Elimination reaction of compound 16 with t-BuOK in THF yielded, as far as, we know the first cyclic paramagnetic diene 17 with a simultaneous trans-esterification reaction (Scheme 3).…”