Efficiency of turnip bioactive lipids in treating osteoporosis through activation of Osterix and suppression of Cathepsin K and TNF-α signaling in rats

Makawy, Aida I. El; Ibrahim, Faten M.; Mabrouk, Dalia M.; Abdel-Aziem, Sekena H.; Sharaf, Hafiza A; Ramadan, Mohamed Fawzy

doi:10.1007/s11356-020-08540-7

Cited by 15 publications

(13 citation statements)

References 46 publications

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“…Amplification was performed with a 15-min denaturation at 95 °C, then 40 cycles of 95 °C for 12 s, 58–63 °C for 15 s, and 72 °C for 30 s. To assess amplification specificity, melting curve analysis was performed. Relative gene expression levels normalized to GAPDH were calculated using the 2−ΔΔCt method according to Livak and Schmittgen (2001) and El-makawy et al. (2020) .…”

Section: Methodsmentioning

confidence: 99%

Nanoencapsulation of basil essential oil alleviates the oxidative stress, genotoxicity and DNA damage in rats exposed to biosynthesized iron nanoparticles

El‐Nekeety

Hassan²,

Hassan

et al. 2021

Heliyon

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The application of essential oils in food and pharmaceutical sectors face several challenges due to their sensitivity to oxidation process. Additionally, the biosynthesis of nanometals is growing rapidly; however, the toxicity of these particles against living organisms did not well explore yet. This study aimed to determine the bioactive compounds in basil essential oil (BEO) using GC-MS, to encapsulate and characterize BEO and to evaluate its protective role against the oxidative stress and genotoxicity of biosynthesized iron nanoparticles (Fe-NPs) in rats. Six groups of male Sprague-Dawley rats were treated orally for 4 weeks included the control group, Fe-NPs-treated group (100 mg/kg b.w.); EBEO-treated groups at low (100 mg/kg b.w.) or high (200 mg/kg b.w.) dose and the groups treated with Fe-NPs plus the low or the high dose of EBEO. The GC-MS analysis revealed the identification of 48 compounds and linalool was the major compound. The average sizes and zeta potential of the synthesized Fe-NPs and EBEO were 60 ± 4.76 and 120 ± 3.2 nm and 42.42 mV and -6.4 mV, respectively. Animals treated with Fe-NPs showed significant increase in serum biochemical analysis, oxidative stress markers, cytokines, lipid profile, DNA fragmentation and antioxidant enzymes and their gene expression and severe changes in the histology of liver and kidney tissues. Administration of Fe-NPs plus EBEO alleviated these disturbances and the high dose could normalize most of the tested parameters and improved the histology of liver and kidney. It could be concluded that caution should be taken in using the biosynthesized metal nanoparticles in different application. EBEO is a potent candidate to protect against the hazards of metal nanoparticles and can be applied in food and medical applications.

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Section: Methodsmentioning

confidence: 99%

Nanoencapsulation of basil essential oil alleviates the oxidative stress, genotoxicity and DNA damage in rats exposed to biosynthesized iron nanoparticles

El‐Nekeety

Hassan²,

Hassan

et al. 2021

Heliyon

Self Cite

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“…acephala ( 7 , 8 ). El-Makawy and his colleagues ( 15 ) reported that the total phenolic content in turnip oil was detected at 4.1 mg GAE/g. Another study conducted by Romani et al ( 9 ) revealed that turnip top contains a high level of polyphenol compounds, especially flavonoids (about 119.2–138.85 mg/100 g), which is about 3–10 times than other Brassica genus.…”

Section: Chemical Composition Of Turnipmentioning

confidence: 99%

“…In addition, one study displayed that turnip oil had high DPPH radical scavenging activity. After mixing with DPPH for 1, 30, and 60 min, 10, 19, and 31% of DPPH radicals were scavenged by turnip oil, respectively ( 15 ).…”

Section: Biological Activities Of Turnipmentioning

confidence: 99%

“…One research on its chemical composition revealed that this plant is a rich resource of glucosinolates ( 1 , 5 , 6 ), phenolic compounds, organic acids ( 7 , 8 ), flavonoids ( 9 ), sulfur compounds ( 10 ), and volatiles ( 2 , 11 , 12 ), which has been found to contribute to different health-beneficial effects. A few studies revealed that turnip exhibits the bioactivities including anti-cancer ( 1 , 2 , 13 ), anti-bacteria ( 1 , 7 ), anti-oxidation ( 6 – 8 , 14 ), anti-radiation ( 15 ), and anti-diabetes ( 16 , 17 ). More recently, several novel biological effects, such as nephroprotection ( 18 ), hypoxia cerebral and pulmonary edema prevention ( 19 , 20 ), and osteoporosis prevention ( 15 ), have been reported to enrich turnip as a functional food.…”

Section: Introductionmentioning

confidence: 99%

“…A few studies revealed that turnip exhibits the bioactivities including anti-cancer ( 1 , 2 , 13 ), anti-bacteria ( 1 , 7 ), anti-oxidation ( 6 – 8 , 14 ), anti-radiation ( 15 ), and anti-diabetes ( 16 , 17 ). More recently, several novel biological effects, such as nephroprotection ( 18 ), hypoxia cerebral and pulmonary edema prevention ( 19 , 20 ), and osteoporosis prevention ( 15 ), have been reported to enrich turnip as a functional food.…”

Section: Introductionmentioning

confidence: 99%

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A Critical Review on Phytochemical Profile and Biological Effects of Turnip (Brassica rapa L.)

2021

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A growing number of medicinal and edible plants have attracted increasing attention due to their abundant constituents and biological activities including turnip. Turnip (Brassica rapa L.) is an herbaceous biennial plant belonging to Cruciferae Brassica. As one of the oldest cultivated vegetables widely consumed in Asia, the turnip has received significant attention in the studies of its bioactive components and biological function. Multiple bioactive components in turnip, such as glucosinolates, isothiocyanate, phenolic compounds, flavonoids, and organic acids, were identified. The bioactivity studies on turnip revealed its anticancer, antimicrobe, anti-hypoxia, anti-diabetes, anti-oxidation, and nephroprotective activity. The present review mainly summarized the previous studies on the chemical compositions of turnip and the bioactivities associated with turnip. Further studies on the extraction and purification of compounds from a turnip as well as its potential molecular mechanisms are highly needed to utilize turnip as a functional food plant in a better way.

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Topiramate potential neurotoxicity and mitigating role of ginger oil in mice brain

Mabrouk

Makawy

Ahmed

et al. 2022

Environ Sci Pollut Res

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Efficiency of turnip bioactive lipids in treating osteoporosis through activation of Osterix and suppression of Cathepsin K and TNF-α signaling in rats

Cited by 15 publications

References 46 publications

Nanoencapsulation of basil essential oil alleviates the oxidative stress, genotoxicity and DNA damage in rats exposed to biosynthesized iron nanoparticles

Nanoencapsulation of basil essential oil alleviates the oxidative stress, genotoxicity and DNA damage in rats exposed to biosynthesized iron nanoparticles

A Critical Review on Phytochemical Profile and Biological Effects of Turnip (Brassica rapa L.)

Topiramate potential neurotoxicity and mitigating role of ginger oil in mice brain

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