Topiramate potential neurotoxicity and mitigating role of ginger oil in mice brain

Mabrouk, Dalia M.; Makawy, Aida I. El; Ahmed, Kawkab A.; Ramadan, Mohamed Fawzy; Ibrahim, Faten M.

doi:10.1007/s11356-022-21878-4

Cited by 6 publications

(2 citation statements)

References 75 publications

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“…Ginger extract has been shown to diminish cerebral infarction and enhance cognitive function in rats, notably by bolstering antioxidant activity in the hippocampus and cortex (Wattanathorn et al 2011). Additionally, ginger protects the brain from oxidative stress neurotoxicity induced by high doses of topiramate (Mabrouk et al 2022), aligning with our study's ndings, wherein ZO supplementation potentially improves recognition memory through enhanced antioxidant status and reduced oxidative stress.…”

Section: Discussionsupporting

confidence: 90%

Reversal of High-Fat Diet-Induced Cognitive Impairment and Oxidative Stress in the Brain through Zingiber officinale Supplementation

Luciano,

Souza,

Oilveira

et al. 2024

Preprint

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Obesity presents a significant health concern, correlating with various adverse health outcomes. Diet-induced obesity (DIO) has been associated with impair on cognitive function. Pharmacological treatments for obesity are limited and may pose serious adverse effects. Ginger possess anti-inflammatory and antioxidant effects in addition to metabolic effects. The study aimed to assess the effects of ginger supplementation on cognitive function, anxiety levels, neurotrophin levels, as well as inflammatory and oxidative status in the cortex following DIO in mice. Swiss male mice, 2 months old, were fed with DIO or standard chow for 4 months and after were subdivided into (n=10/group): i) CNT (CNT + vehicle); ii) CNT supplemented with ZO (CNT + ZO); iii) obese mice (DIO + vehicle) ; iv) obese mice supplemented with ZO (DIO + ZO) (n=10). Zingiber officinale (ZO) 400 mg/kg/day were supplemented for 35 days by oral gavage. DIO + vehicle group shown impaired on recognition memory task. CNT + ZO group showed a higher number of crossings in the open field. There were no difference between group in plus maze task. DIO + vehicle had increased the DCFH and carbonylation levels in cortex. The DIO + vehicle showed a reduction in catalase activity. The cerebral cortex did not show any difference regarding to inflammatory and neurotrophins markers. In conclusion, our findings indicate that supplementation with ZO reverses cognitive impairment in DIO mice and enhances antioxidant status in the cerebral cortex.

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Section: Discussionsupporting

confidence: 90%

Reversal of High-Fat Diet-Induced Cognitive Impairment and Oxidative Stress in the Brain through Zingiber officinale Supplementation

Luciano,

Souza,

Oilveira

et al. 2024

Preprint

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“…These compounds are thought to interact with gamma-aminobutyric acid (GABA) receptors in the brain, leading to increased GABAergic activity. GABA is an inhibitory neurotransmitter that helps regulate anxiety and stress responses by reducing neuronal excitability [ 89 ]. By enhancing GABAergic neurotransmission, ginger may promote relaxation and decrease anxiety levels.…”

Section: Discussionmentioning

confidence: 99%

Effects of Aphrodite (an Herbal Compound) on SSRI-Induced Sexual Dysfunctions and Depression in Females with Major Depressive Disorder: Findings from a Randomized Clinical Trial

Shahmoradi,

Davarinejad,

Brühl

et al. 2023

Medicina

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Background and Objectives: Almost by default, people with major depression disorder (MDD) also report sexual health issues. This holds even more true when sexual dysfunctions are SSRI-induced. Herbal compounds may have the power to counterbalance such sexual dysfunctions, though research is still scarce. Therefore, we assessed females with diagnosed MDD treated with a standard SSRI (sertraline) and reporting SSRI-induced sexual dysfunctions, and we asked whether compared to placebo, Aphrodite® (a blend of ginger, saffron, cinnamon, thistle, and Tribulus terrestris) may favorably impact on sexual dysfunctions, and on symptoms of depression, anxiety, and sleep disturbances. Materials and Methods: A total of 41 females (mean age: 35.05 years) with diagnosed MDD, treated with sertraline (a standard SSRI) at therapeutic dosages, and reporting SSRI-induced sexual dysfunction, were randomly assigned either to Aphrodite or to the placebo condition. At baseline and four and eight weeks later (study end), participants completed a series of self-rating questionnaires covering symptoms of sexual dysfunction, depression, anxiety, and sleep complaints. Results: Symptoms of sexual dysfunction, depression, and anxiety decreased over time, but more so in the Aphrodite condition, compared to the placebo condition (significant p-values and large effect sizes). Over time, sleep disturbances decreased irrespective of the study condition. Conclusions: The pattern of results suggests that compared to placebo, Aphrodite appeared to improve symptoms of sexual dysfunction, depression, and anxiety among females with diagnosed MDD and SSRI-induced sexual dysfunction. Further and similar studies should investigate the underlying psychophysiological mechanisms.

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Reversal of high-fat diet-induced cognitive impairment and oxidative stress in the brain through Zingiber officinale supplementation

Luciano,

Teodoro de Souza,

de Oliveira

et al. 2024

Metab Brain Dis

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Topiramate potential neurotoxicity and mitigating role of ginger oil in mice brain

Cited by 6 publications

References 75 publications

Reversal of High-Fat Diet-Induced Cognitive Impairment and Oxidative Stress in the Brain through Zingiber officinale Supplementation

Reversal of High-Fat Diet-Induced Cognitive Impairment and Oxidative Stress in the Brain through Zingiber officinale Supplementation

Effects of Aphrodite (an Herbal Compound) on SSRI-Induced Sexual Dysfunctions and Depression in Females with Major Depressive Disorder: Findings from a Randomized Clinical Trial

Reversal of high-fat diet-induced cognitive impairment and oxidative stress in the brain through Zingiber officinale supplementation

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