The article presents the results of studies on the effectiveness of mineral fertilizers (zinc and copper) in the cultivation of perennial medicinal crops (Achillea millefoliumL.,Tanacetum vulgareL.,Echinacea purpureaL.) on meadow-chernozem soil in the southern forest-steppe of Western Siberia. It was found that the most effective forAchillea millefoliumwas the application of copper fertilizers in the soil at a dose of Cu9.7, providing an increase in yield by 43.2 % relative to background; forTanacetum vulgare –zinc fertilizers at a dose of Zn60(+42.9 % relative to background) and forEchinacea purpureacopper fertilizers at a dose of Cu9.4(+60.3 % relative to background).