Efficiency of hyperbaric oxygen therapy in experimental acute acoustic trauma from firearms

Kuokkanen, Antti A. Aarnisalo Juha

doi:10.1080/000164800454206

Cited by 24 publications

(10 citation statements)

References 11 publications

(10 reference statements)

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“…This has not been a universal finding, however. In the study by Kuokkanen et al (2000) rats were exposed to impulse noise and HBO was given daily for 10 days. Hair cell survival was improved in the HBO treatment group compared to controls (Kuokkanen et al, 2000).…”

Section: Oxygen As a Cochlear Therapeuticmentioning

confidence: 99%

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Use of Gases to Treat Cochlear Conditions

Buckey¹

2019

Front. Cell. Neurosci.

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Although the cochlear vascular supply (stria vascularis) is designed to block to certain compounds and molecules, it must enable gas exchange to survive. The inner ear capillaries must deliver oxygen and remove carbon dioxide for the cochlea to function. These gases diffuse through tissues across a concentration gradient to reach the desired target. Tight junctions or the endothelial basement membrane do not impede them. Therefore, gases that can diffuse into the inner ear are attractive as therapeutic agents. The two gases most often used in this way are oxygen and hydrogen, although carbon dioxide, ozone, and argon have also been investigated. Typically, oxygen is delivered as hyperbaric oxygen (HBO) (oxygen at pressure higher than atmospheric) to provide increased oxygen levels to the inner ear. This not only relieves hypoxia, but also has anti-inflammatory and other biochemical effects. HBO is used clinically to treat idiopathic sudden sensorineural hearing loss, and both animal and human studies suggest it may also assist recovery after acute acoustic trauma. Laboratory studies suggest hydrogen works as a free radical scavenger and reduces the strong oxidants hydroxyl radicals and peroxynitrite. It also has anti-apoptotic effects. Because of its anti-oxidant and anti-inflammatory effects, it has been studied as a treatment for ototoxicity and shows benefit in an animal model of cisplatinum toxicity. Gas diffusion offers an effective way to provide therapy to the inner ear, particularly since some gases (oxygen, hydrogen, carbon dioxide, ozone, argon) have important therapeutic effects for minimizing cochlear damage.

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Section: Oxygen As a Cochlear Therapeuticmentioning

confidence: 99%

“…In the study by Kuokkanen et al (2000) rats were exposed to impulse noise and HBO was given daily for 10 days. Hair cell survival was improved in the HBO treatment group compared to controls (Kuokkanen et al, 2000). Recent studies in humans suggest benefit from HBO after acute acoustic trauma (Bayoumy et al, 2019).…”

Section: Oxygen As a Cochlear Therapeuticmentioning

confidence: 99%

Use of Gases to Treat Cochlear Conditions

Buckey¹

2019

Front. Cell. Neurosci.

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“…Administration of therapy (of AAT) is quintessentially begun within 24 h after the acoustic trauma [ 9 , 10 , 11 ]. Using the data analysis of our group of patients undergoing standardized medical protocols (corticosteroid therapy, HBO2 therapy), we aim to prove a causal connection between starting early treatment and a better prognosis for hearing loss improvement, thus proving our objective [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although 75% of AAT of cases can be classified as occupational accidents, an absolutely necessary precondition is good awareness and cooperation of military general practitioners, through immediate administration of corticosteroid therapy at the site of trauma with prompt referral of soldiers to the relevant military hospital for further therapy (corticosteroid therapy, vasodilator treatment, and HBO2 therapy). For instance, in Finland, just as in the Czech Republic, several hundred soldiers suffer from AAT every year despite strict security regulations dealing with shooting from firearms in defense forces, in the USA, 20–30% of soldiers experience hearing impairment [ 1 , 9 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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The Use of Hyperbaric Oxygen Therapy and Corticosteroid Therapy in Acute Acoustic Trauma: 15 Years’ Experience at the Czech Military Health Service

Holý

Zavázalová

Procházková

et al. 2021

IJERPH

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Background: Acute acoustic trauma (AAT) ranks, among others, as one common cause of inner ear function impairment, especially in terms of military personnel, who are at an increased exposure to impulse noises from firearms. Aim of this study: 1. We wanted to demonstrate whether early treatment of AAT means a higher chance for the patient to improve hearing after trauma. 2. We find the answer to the question of whether hyperbaric oxygen therapy (HBO2) has a positive effect in the treatment of AAT. Methods: We retrospectively analyzed data for the period 2004–2019 in patients with AAT. We evaluated the therapeutic success of corticosteroids and HBO2 in a cohort of patients with AAT n = 108 patients/n = 141 affected ears. Results: Hearing improvement after treatment was recorded in a total of 111 ears (79%). In terms of the data analysis we were able to ascertain, utilizing success of treatment versus timing: within 24 h following the onset of therapy in 56 (40%) ears—54 (96%) ears had improved; within seven days following the onset the therapy was used in 55 (39%) ears—41 (74%) ears had improved; after seven days the therapy started in 30 (21%) ears—16 (53%) ears had improved. Parameter latency of the beginning of the treatment of AAT was statistically significant (p = 0.001 and 0.017, respectively). The success of the medical protocols was apparent in both groups—group I (treated without HBO2): n = 61 ears, of which 50 (82%) improved, group II (treated with HBO2): n = 73 ears, of which 56 (77%) improved. Group II shows improvement at most frequencies (500–2000 Hz). The most serious sensorineural hearing loss after AAT was at a frequency of 6000 Hz. Conclusion: Analysis of our data shows that there is a statistically significant higher rate of improvement if AAT treatment was initiated within the first seven days after acoustic trauma. Early treatment of AAT leads to better treatment success. HBO2 is considered a rescue therapy for the treatment of AAT. According to our recommendation, it is desirable to start corticosteroid therapy immediately after acoustic trauma. If hearing does not improve during the first seven days of corticosteroid therapy, then HBO2 treatment should be initiated.

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HBO Therapy in Otolaryngology

Jain¹

2017

Textbook of Hyperbaric Medicine

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Efficiency of hyperbaric oxygen therapy in experimental acute acoustic trauma from firearms

Cited by 24 publications

References 11 publications

Use of Gases to Treat Cochlear Conditions

Use of Gases to Treat Cochlear Conditions

The Use of Hyperbaric Oxygen Therapy and Corticosteroid Therapy in Acute Acoustic Trauma: 15 Years’ Experience at the Czech Military Health Service

HBO Therapy in Otolaryngology

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