Use of Gases to Treat Cochlear Conditions

Buckey, Jay C.

doi:10.3389/fncel.2019.00155

Cited by 7 publications

(7 citation statements)

References 49 publications

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“…This atrophy leads to extensive damage. 13 , 31 It is difficult to conclude with this contradictory data. However, it is clear that HBOT and NBOT have a detrimental effect on recovery from AAT in some cases.…”

Section: Discussionmentioning

confidence: 99%

Effects of Oxygen Therapies in Experimental Acute Acoustic Trauma

Ata¹,

Kahraman²,

İncesulu³

et al. 2021

Int Adv Otol

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Background: Acute acoustic trauma is defined as a sudden sensorineural hearing loss that occurs after an exposure to acoustic overstimulation. Increasing the oxygen in perilymph can be a treatment modality. Our study aims to investigate the influence of normobaric oxygen therapy on the recovery of acute acoustic trauma and to compare it with the hyperbaric oxygen therapy. Methods: Three groups of rats (5 rats each) were exposed to white noise for 1 hour. Sensorineural hearing loss was identified using distortion product otoacoustic emission. Subsequently, the first group was treated with hyperbaric oxygen therapy, the second group was treated with normobaric oxygen therapy, and the third group did not receive any treatment and was used as a control group. Results: There was a statistically significant difference within time for frequencies of 1, 1.5, and 2 kHz, but there was no statistically significant difference between groups. For frequencies of 3, 4, 5, and 6 kHz, there was a statistically significant difference within time and between groups. Between groups, recovery of distortion product otoacoustic emission values in all frequencies was better in the control group by the third, fifth, and seventh days. Comparing the values of hyperbaric oxygen therapy and normobaric oxygen therapy groups, it was observed that by the third day, the hyperbaric oxygen therapy values were better than those of the normobaric oxygen therapy values. However, by the fifth and seventh days, the normobaric oxygen therapy values were better (except at a frequency of 1 kHz). Conclusion: Because there is a high rate of spontaneous recovery, physicians should be more selective to treat patients with oxygen therapies.

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Section: Discussionmentioning

confidence: 99%

Effects of Oxygen Therapies in Experimental Acute Acoustic Trauma

Ata¹,

Kahraman²,

İncesulu³

et al. 2021

Int Adv Otol

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“…During hyperbaric oxygen therapy (HBOT) 100% O 2 is breath in under pressures that equals 2–3 times the atmospheric pressure and resembles a dive at approximately 15 m underwater [ 61 ]. HBOT is frequently used in the military for the treatment of decompression disease and for treatment of acute acoustic trauma [ 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Management of tympanic membrane retractions: a systematic review

Bayoumy

Veugen

Veen

et al. 2021

Eur Arch Otorhinolaryngol

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Importance Tympanic membrane retraction (TMR) is a relatively common otological finding. However, no consensus on its management exists. We are looking especially for a treatment strategy in the military population who are unable to attend frequent follow-up visits, and who experience relatively more barotrauma at great heights and depths and easily suffer from otitis externa from less hygienic circumstances. Objective To assess and summarize the available evidence for the effectiveness of surgical interventions and watchful waiting policy in patients with a tympanic membrane retraction. Evidence review The protocol for this systematic review was published at Prospero (207859). PubMed, Embase, and the Cochrane Database of Systematic Reviews were systematically searched from inception up to September 2020 for published and unpublished studies. We included randomized trials and observational studies that investigated surgical interventions (tympanoplasty, ventilation tube insertion) and wait-and-see policy. The primary outcomes of this study were clinical remission of the tympanic membrane retraction, tympanic membrane perforations and cholesteatoma development. Findings In total, 27 studies were included, consisting of 1566 patients with TMRs. We included data from 2 randomized controlled trials (76 patients) and 25 observational studies (1490 patients). Seven studies (329 patients) investigated excision of the TMR with and without ventilation tube placement, 3 studies (207 patients) investigated the wait-and-see policy and 17 studies (1030 patients) investigated tympanoplasty for the treatment of TMRs. Conclusions and relevance This study provides all the studies that have been published on the surgical management and wait-and-policy for tympanic membrane retractions. No high level of evidence comparative studies has been performed. The evidence for the management of tympanic membrane retractions is heterogenous and depends on many factors such as the patient population, location and severity of the TMR and presence of other ear pathologies (e.g., perforation, risk of cholesteatoma and serous otitis media).

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“…HBOT increases the partial pressure of oxygen, promoting the delivery of more oxygen to the cochlea, which is very sensitive to hypoxia. 33,34 Further, acupuncture is believed to have local positive effects on the modulation of tissue hypoxia by way of increasing blood flow to the ear. 8,12,27,30 Both treatment modalities improve vascular compromise and associated cochlear ischemia, which is a potential etiology of ISSNHL in some cases and may be part of the final common pathway to hearing loss.…”

Section: Discussionmentioning

confidence: 99%

Combined Acupuncture-Hyperbaric Oxygen-Steroids Therapy for Idiopathic Sudden Sensorineural Hearing Loss: A Retrospective Observational Study

Lee

Chen

Shih

et al. 2021

The Journal of Alternative and Complementary Medicine

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Objectives: Acupuncture, widely used in Chinese society, has been studied as an adjunct treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). The purpose of this study is to investigate the effectiveness of combined acupuncture and hyperbaric oxygen therapy (HBOT) with conventional steroid therapy for ISSNHL.Methods: This retrospective chart review enrolled 154 patients who met the ISSNHL criteria and were categorized into three groups according to the different treatment regimens. Among these patients, 43 underwent steroid therapy only (S) group, 74 received steroid and HBOT (S-H) group, and the remaining 37 were treated with combined acupuncture-HBOT in addition to steroid therapy (S-H-A) group. The outcome was determined by comparing the differences in pure-tone thresholds and absolute hearing gains after treatment calculated at each audiometric octave frequency or grouped frequencies of audiograms. Hearing recoveries classified into three grades: complete, partial, and poor were also analyzed and compared among different treatment groups.Results: All subjects presented with initial severe hearing loss with averaged hearing thresholds >70 dB. The S-H-A group exhibited good hearing improvement outcomes at each audiometric octave frequency and grouped frequencies of audiograms, with greater hearing gain and had more favorable outcomes in hearing recovery grades compared with the S group and the S-H group.Conclusions: The results obtained in this study revealed a preliminary finding of ISSNHL patients benefiting from combined acupuncture, HBOT, and conventional steroid therapy. Acupuncture is a safe and nonpharmacologic treatment option and can be considered as an initial treatment strategy in such a clinical scenario.

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Use of Gases to Treat Cochlear Conditions

Cited by 7 publications

References 49 publications

Effects of Oxygen Therapies in Experimental Acute Acoustic Trauma

Effects of Oxygen Therapies in Experimental Acute Acoustic Trauma

Management of tympanic membrane retractions: a systematic review

Combined Acupuncture-Hyperbaric Oxygen-Steroids Therapy for Idiopathic Sudden Sensorineural Hearing Loss: A Retrospective Observational Study

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