Efficiency of a self-administered outpatient parenteral antimicrobial therapy (s-opat) for infective endocarditis within the context of a shortened hospital admission based on hospital at home program

Abstract

In suitably selected patients, treatment of IE based on S-OPAT supported by a shortening hospital admission care program by means of referral to a HAH unit is a safe and efficient care model which entails a significant cost saving for the public healthcare system.

Efficacy and safety of outpatient parenteral antibiotic therapy in patients with infective endocarditis: a meta-analysis

“…Current research data show that OPAT has a good therapeutic effect on IE patients, and it is expected that OPAT will continue to show a good effect in the treatment of IE patients in the future. OPAT has also shown many benefits, such as providing significant cost effectiveness to inpatient management [ 1 , 13 , 16 , 19 , 20 ], not only by reducing the cost of treatment for patients, but also by bringing benefits to the healthcare delivery system. A study from Europe showed that the use of OPAT therapy for IE reduced costs by approximately €15,000 per patient [ 16 ].…”

“…Most OPATs follow two main models: First, infusion in the patient’s home, which is called “health care professional outpatient parenteral antimicrobial therapy (H-OPAT)”, with active caregiver intervention. Second, “self-service outpatient parenteral antimicrobial therapy (S-OPAT)”, in which health-care personnel initially train patients and/or their caregivers in the use of antimicrobial agents, so the physical presence of healthcare personnel at home during infusion is subsequently unnecessary [ 13 , 22 ]. In the above two modes of OPAT services, the relationship between patients and medical staff is not very close.…”

“…The results revealed that 3 cohort studies showed 9 points, and 2 cohort studies showed 7 points. The articles by Htin et al [ 12 ] and Pajarón et al [ 13 ] did not describe the results during follow-up period.…”

“…A 95% confidence interval (95% CI) was used to determine the statistical Quality assessment of included studies. a) Quality assessment of 5 cohort studies [9,10,12,13,15]:…”

“…that OPAT is safe and effective for the treatment of IE [9][10][11][12][13][14][15][16][17]. A study by Kortajarena et al sreported that only 1 in 194 patients diagnosed with IE died during follow-up after medication [9].…”