Efficacy trials in turkey poults with tylosin tartrate against Mycoplasma gallisepticum and Mycoplasma meleagridis

Wise, D.R.; Fuller, M.K.

doi:10.1016/s0034-5288(18)33515-x

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…After oral administration of 10 mg/kg of tylosin tartrate, the plasma concentrations were higher than the MIC values effective against broiler chickens pathogens such as Mycoplasma gallisepticum (MIC = 0.1 μg/mL: Wise & Fuller, ; MIC = 0.05 μg/mL: Wang et al ., ) Mycoplasma meleagridis (MIC = 0.1 μg/mL: Wise & Fuller, ), Mycoplasma synoviae (MIC = 0.13 μg/mL: Wang et al ., ), Mycoplasma agalactiae (MIC 50 = 0.292 μg/mL: Loria et al ., ), and field isolates of mycoplasma from poultry (MIC = 0.08~2 μg/mL: Cooper et al ., ; Hannan et al ., ). The plasma levels detected in this study indicate that intervals of at least 3 h will be effective, as plasma levels of 0.19 μg/mL and 0.22 μg/mL were found at 0.67 and 3 h, respectively.…”

Section: Pharmacokinetic Parameters Of Tylosin After IV Administrationmentioning

confidence: 99%

Comparative pharmacokinetics and bioavailability of tylosin tartrate and tylosin phosphate after a single oral and i.v. administration in chickens

Dong

et al. 2013

Vet Pharm & Therapeutics

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The pharmacokinetics and oral bioavailability of tylosin tartrate and tylosin phosphate were carried out in broiler chickens according to a principle of single dose, random, parallel design. The two formulations of tylosin were given orally and intravenously at a dose level of 10 mg/kg b.w to chicken after an overnight fasting (n = 10 chickens/group). Serial blood samples were collected at different time points up to 24 h postdrug administration. A high performance liquid chromatography method was used for the determination of tylosin concentrations in chicken plasma. The tylosin plasma concentration's time plot of each chicken was analyzed by the 3P97 software. The pharmacokinetics of tylosin was best described by a one-compartmental open model 1st absorption after oral administration. After intravenous administration the pharmacokinetics of tylosin was best described by a two-compartmental open model, and there were no significant differences between tylosin tartrate and tylosin phosphate. After oral administration, there were significant differences in the Cmax (0.18 ± 0.01, 0.44 ± 0.09) and AUC (0.82 ± 0.05, 1.57 ± 0.25)between tylosin phosphate and tylosin tartrate. The calculated oral bioavailability (F) of tylosin tartrate and tylosin phosphate were 25.78% and 13.73%, respectively. Above all, we can reasonably conclude that, the absorption of tylosin tartrate is better than tylosin phosphate after oral administration.

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Section: Pharmacokinetic Parameters Of Tylosin After IV Administrationmentioning

confidence: 99%

Comparative pharmacokinetics and bioavailability of tylosin tartrate and tylosin phosphate after a single oral and i.v. administration in chickens

Dong

et al. 2013

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

show abstract

Chemotherapy of Mycoplasma Infections

Brünner¹,

Laber²

1985

Mycoplasma Pathogenicity

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Prevention of egg transmission and heterogeneity among isolates of Mycoplasma meleagridis

Elmahi

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Efficacy trials in turkey poults with tylosin tartrate against Mycoplasma gallisepticum and Mycoplasma meleagridis

Cited by 3 publications

References 5 publications

Comparative pharmacokinetics and bioavailability of tylosin tartrate and tylosin phosphate after a single oral and i.v. administration in chickens

Comparative pharmacokinetics and bioavailability of tylosin tartrate and tylosin phosphate after a single oral and i.v. administration in chickens

Chemotherapy of Mycoplasma Infections

Prevention of egg transmission and heterogeneity among isolates of Mycoplasma meleagridis

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