Comparative pharmacokinetics and bioavailability of tylosin tartrate and tylosin phosphate after a single oral and i.v. administration in chickens

Ji, Liwei; Dong, Lingling; Ji, Huyan; Xia, Feng; Li, D.; Ding, Reinhard; Jiang, Shanxiang

doi:10.1111/jvp.12092

Cited by 19 publications

(23 citation statements)

References 17 publications

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“…administration at a dose of 50 mg/kg.b.wt. This result is consistent with [20]. Tylosin in Tylan Soluble ® was highly distributed with great extent to all tissues V c , V d area and V dss ; (exceeded one liter/kg).…”

Section: Discussionsupporting

confidence: 88%

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Soliman¹,

Sedek²

2016

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The pharmacokinetics and tissue residue of tylosin in broiler chickens were studied after I.V. and oral administrations in a dose of 50 mg tylosin/kg.b.wt. Tylosin was obeyed a two-compartment open model following I.V. administration at a dose of 50 mg/kg.b.wt. The disposition kinetics of tylosin following I.V. administration revealed that tylosin was highly distributed with Vd(area) of 6 L/kg and eliminated with half-life (t1/2β) equal to 7.29 hours. The disposition kinetics of tylosin following oral administration revealed that the maximum blood concentration (Cmax) was 3.40 µg/ml attained at (tmax) of 1.08 hour. Tylosin was eliminated with half-life (t1/2β) equal to 5.78 hours. The mean systemic bioavailability of tylosin after oral administration was 90.29%. Following repeated oral administration of 50 mg tylosin base/kg.b.wt once daily for 5 consecutive days, the blood (µg/ml) and tissue (µg/g) residues of tylosin showed that liver, kidney and lung contained the highest tylosin residues and completely disappeared from those tissues at 6 days after the last oral dose. Chickens should not be slaughtered for human consumption within the treatment and 6 days after the last oral administrations of tylosin.

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Section: Discussionsupporting

confidence: 88%

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Soliman¹,

Sedek²

2016

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“…One chicken was randomly selected as the blank control group and the other two chickens received nine antimicrobials. Dosage, time of administration, and time point of slaughter [ 36 , 37 , 38 , 39 ] are shown in Table 5 .…”

Section: Methodsmentioning

confidence: 99%

Quick Multi-Class Determination of Residues of Antimicrobial Veterinary Drugs in Animal Muscle by LC-MS/MS

Zhang

et al. 2018

Molecules

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On the basis of the highly sensitive and selective liquid chromatography-tandem mass spectrometry technique, a generic extraction solvent and a sample dilution method was developed for the residue analysis of different polar veterinary drugs known as fluoroquinolones, sulfonamides, macrolides, and tiamulin in chicken muscle. The results showed that the matrix-matched calibration curves of all 10 compounds were in an effective linear relationship (r2 ≥ 0.997) in the range of 0.2–100 μg L−1. At three spiking levels of 2 (5), 50, and 100 μg kg−1, average recoveries of analytes were between 67.1% and 96.6% with relative standard deviations of intra-day and inter-day below 20%. The limits of detection and limits of quantification of the method were in the range of 0.3–2.0 μg kg−1 and 2.0–5.0 μg kg−1, respectively, which were significantly lower than their maximum residue limits. In addition, the intensity of the target analytes and its corresponding matrix effects were obviously related to the sample dilution times (matrix concentration). There were no significant differences (p > 0.05) in the average content of almost any of the analytes in medicated chickens between this method and the method in the literature for determining analytes. Lastly, the proposed method was successfully applied for the simultaneous analysis of 10 common veterinary drugs in food animal muscle tissues.

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“…It could be hypothesized that the amniocentesis at 28 dpi contributed to the possible intrauterine bacterial infection; however, the long duration of time (21 days) separating these events, and the typical rapidity of preterm labor in the rhesus macaque with experimental bacterial infection of the amniotic fluid makes this unlikely [ 74 , 75 ]. It is possible that the use of tylosin, a systemically absorbed bacteriostatic macrolide [ 76 ] commonly used for chronic diarrhea suppression in captive nonhuman primate colonies [ 77 ], contributed to bacterial growth suppression in a bacterial placentitis and masked signs of acute chorioamnionitis following the amniocentesis; this theory cannot be proved or disproved in this case report. Additional studies of ZIKV infection during NHP pregnancy are needed to determine if there is an association between congenital ZIKV infection and an increased risk for intraamniotic infection leading to PPROM and fetal demise.…”

Section: Fetal Demisementioning

confidence: 99%

Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection

et al. 2018

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Congenital Zika virus (ZIKV) infection impacts fetal development and pregnancy outcomes. We infected a pregnant rhesus macaque with a Puerto Rican ZIKV isolate in the first trimester. The pregnancy was complicated by preterm premature rupture of membranes (PPROM), intraamniotic bacterial infection and fetal demise 49 days post infection (gestational day 95). Significant pathology at the maternal-fetal interface included acute chorioamnionitis, placental infarcts, and leukocytoclastic vasculitis of the myometrial radial arteries. ZIKV RNA was disseminated throughout fetal tissues and maternal immune system tissues at necropsy, as assessed by quantitative RT-PCR for viral RNA. Replicating ZIKV was identified in fetal tissues, maternal uterus, and maternal spleen by fluorescent in situ hybridization for viral replication intermediates. Fetal ocular pathology included a choroidal coloboma, suspected anterior segment dysgenesis, and a dysplastic retina. This is the first report of ocular pathology and prolonged viral replication in both maternal and fetal tissues following congenital ZIKV infection in a rhesus macaque. PPROM followed by fetal demise and severe pathology of the visual system have not been described in macaque congenital ZIKV infection previously. While this case of ZIKV infection during pregnancy was complicated by bacterial infection with PPROM, the role of ZIKV on this outcome cannot be precisely defined, and further nonhuman primate studies will determine if increased risk for PLOS ONE | https://doi.org/10.1371/journal.pone

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Comparative pharmacokinetics and bioavailability of tylosin tartrate and tylosin phosphate after a single oral and i.v. administration in chickens

Cited by 19 publications

References 17 publications

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Quick Multi-Class Determination of Residues of Antimicrobial Veterinary Drugs in Animal Muscle by LC-MS/MS

Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection

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