Efficacy study of two novel hyaluronic acid-based formulations for viscosupplementation therapy in an early osteoarthrosic rabbit model

Kaderli, S.; Viguier, É.; Watrelot-Virieux, D.; Roger, Thierry; Gurny, Robert; Scapozza, Léonardo; Möller, Michael; Boulocher, C.; Jordan, Olivier

doi:10.1016/j.ejpb.2015.09.005

Cited by 21 publications

(20 citation statements)

References 37 publications

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“…The first method is used to provide viscosupplements to the cartilage . For instance, the intra‐articular injection of chitosan–hyaluronate hydrogels is effective in repairing the cartilage defects because of their resemblances to the native ECM of the articular cartilage .…”

Section: Multiple Applicationsmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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The repair of tissue defects after injury is of significant clinical and research importance. A variety of chitosan‐based hydrogels have been investigated and applied to address this problem. By using different synthetic methods, the hydrogels exhibit distinct physical properties, including porosity, adhesion, and stiffness. These properties are considered important factors affecting cell proliferation and tissue regeneration. Meanwhile, drug delivery and cell delivery are the two main strategies to improve the therapeutic effects of chitosan‐based hydrogels, but the choices of cells or drugs are quite varied and largely depend on the specificity of the treated tissues. The present review summarizes the physicochemical properties of chitosan‐based hydrogels and their influences on cells, and lists specific ways to promote the tissue regeneration in different systems of the human body. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47235.

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Section: Multiple Applicationsmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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“…The 18 rabbits were randomized into 3 groups of 6 rabbits. Each ACLT knee (left knee) was treated by intra-articular injection of 0.2 ml of either Saline solution, HA commercial formulation (Ostenil®, TRB Chemedica, Switzerland), or novel hybrid hydrogel formulation (Cs added to HA) [ 25 , 33 , 34 ], respectively called hereafter Saline-group, HA-group and Hybrid-group. Eight non-operated right knees (randomly chosen within groups) were used as non-operated controls (referred hereafter to as Contralateral-group, n = 8).…”

Section: Methodsmentioning

confidence: 99%

Chitosan in viscosupplementation: in vivo effect on rabbit subchondral bone

Rieger

Boulocher

Kaderli

et al. 2017

BMC Musculoskelet Disord

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BackgroundTo investigate the effect of intra-articular injection of Chitosan (Cs) added to hyaluronic acid (HA) on subchondral bone during osteoarthritis (OA), microarchitectural parameters and mineral density were measured in a rabbit model of early OA. A novel hybrid hydrogel adding reacetylated Cs of fungal origin to HA was compared to high molecular weight HA commercial formulation.MethodEighteen rabbits underwent unilateral anterior cruciate ligament transection (ACLT) and were divided into three groups (Saline-group, HA-group and Hybrid-group) depending on the intra-articular injection compound. Eight contralateral knees were used as non-operated controls (Contralateral-group). Micro-computed tomography was performed six weeks post-ACLT to study subchondral bone microarchitectural parameters and mineral density at an early stage of OA development.ResultsCartilage thickness mean value was reduced only in Saline-group compared to Contralateral-group. When the Hybrid-group was compared to Saline-group, subchondral bone microarchitectural parameters (trabecular thickness and trabecular bone volume fraction) were significantly changed; subchondral bone plate and trabecular bone mineral densities (bone mineral density and tissue mineral density) were reduced. When the Hybrid-group was compared to HA-group, subchondral bone microarchitectural parameters (subchondral plate thickness and trabecular thickness) and trabecular bone mineral densities (bone mineral density and tissue mineral density) were significantly decreased.ConclusionConclusion: Compared to HA alone, the novel hybrid hydrogel, constituted of Cs added to HA, enhanced microarchitectural parameters and mineral density changes, leading to subchondral bone loss in a rabbit model of early experimental OA.

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“…is injectable hydrogel possesses an adjustable three-dimensional microenvironment that is able to alter cell condensation during chondrogenesis and improve the histogeny of the overall cartilage tissue [85]. Kaderli and colleagues [86] found that HA-4-aminoresorcinol (HA-4AR) hydrogels have protective effects on cartilage and can reduce the generation of synovium hypertrophy. Unterman and colleagues [87] used an HA-binding peptide (HABPep) to specifically bind HA to restrain HA-mediated delivery of hemameba.…”

Section: Modification With Othermentioning

confidence: 99%

“…Its hydraulic time, microstructure, surface morphology, equilibrium swelling, compression modulus, and degradation in vitro are suitable, and the effects of coating chondrocytes are obvious [102]. In experiments in rabbits, HA-acetylation chitosan hydrogels have surprisingly augmented subchondral bone remodeling and cartilage formation [86]. e porosity of lyophilized chitosan-HA-dialdehyde gels increases with the degree of oxidation, and chondrocytes coated in CHDA gel retain their viability and special phenotypic characteristics [102].…”

Section: Binding Tomentioning

confidence: 99%

The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering

Zheng

et al. 2019

Advances in Materials Science and Engineering

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At present, the healing of osteopathy, especially the healing of cartilage, has been proven to be difficult. Commonly used treatment methods are autogenous bone grafts and allogeneic bone grafts, but grafts cannot fully meet the clinical treatment requirements due to problems related to the source, price, immunity, and other concerns. us, the combination of biomaterials and tissue engineering technology has become a new direction in research. Among studies on tissue engineering bone and cartilage materials, hydrogels that show biological activity, absorbability after degradability, plasticity, and easy preparation have become the focus. Hydrogels are used as extracellular matrix mimics. Although various materials are able to form hydrogels, hyaluronic acid and its derivatives are prominently used. Hyaluronic acid hydrogels have many advantages, such as promoting cell adhesion and proliferation and wound healing. ey also demonstrate sufficient biological activity for stimulating a microenvironment for cell survival. However, their disadvantages require further modification and include a poor degradation rate and insufficient mechanical performance. In this paper, hyaluronic acid-based hydrogels, their modifications, applications, and mechanisms, as well as new techniques for processing hyaluronic acid hydrogels in bone and cartilage tissue engineering, are briefly reviewed, and their future prospects and directions for future work are discussed.

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Efficacy study of two novel hyaluronic acid-based formulations for viscosupplementation therapy in an early osteoarthrosic rabbit model

Cited by 21 publications

References 37 publications

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Chitosan in viscosupplementation: in vivo effect on rabbit subchondral bone

The Application of Hyaluronic Acid-Based Hydrogels in Bone and Cartilage Tissue Engineering

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