Efficacy, safety, and economic impact of diazepam suppositories with as‐needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures

Tanaka, Miki; Wang, Qianzhi; Morikawa, Yoshihiko; Tsukamoto, Junya; Sammori, Hiroaki; Takehira, Ken; Yano, Mizuki; Miyama, Satoshi; Fujita, Saki; Narita, Kazutoshi; Kishibe, Shun; Morikawa, Emi; Suzuki, Satoko; Hataya, Hiroshi

doi:10.1111/epi.17271

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Diazepam is used as a treatment for FS to enhance GABA-mediated inhibition of neuronal activity, which acts as a seizure suppressor ( Natsume et al, 2017 ). In a study of children with FS for the first time, patients who used both diazepam and acetaminophen had fewer recurrences than those who used diazepam alone ( Tanaka et al, 2022 ). The prophylactic use of diazepam has been controversial.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of the recent advances in diazepam from 2012 to 2021

Zhang

Kou²,

Qin³

et al. 2022

Front. Pharmacol.

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Background: Diazepam is a classic benzodiazepine drug that has been widely used for disorders such as anxiety, sleep disorders, and epilepsy, over the past 59 years. The study of diazepam has always been an important research topic. However, there are few bibliometric analyses or systematic studies in this field. This study undertook bibliometric and visual analysis to ascertain the current status of diazepam research, and to identify research hotspots and trends in the past 10 years, to better understand future developments in basic and clinical research.Methods: Articles and reviews of diazepam were retrieved from the Web of Science core collection. Using CiteSpace, VOSviewer, and Scimago Graphica software, countries, institutions, authors, journals, references, and keywords in the field were visually analyzed.Results: A total of 3,870 publications were included. Diazepam-related literature had high volumes of publications and citations. The majority of publications were from the USA and China. The highest number of publications and co-citations, among the authors, was by James M Cook. Epilepsia and the Latin American Journal of Pharmacy were the journals with the most publications on diazepam and Epilepsia was the most frequently cited journal. Through a comprehensive analysis of keywords and references, we found that current research on diazepam has focused on its mechanism of action, application in disease, pharmacokinetics, risk, assessment, and management of use, status epilepticus, gamma-aminobutyric acid receptors (GABAR), intranasal formulation, gephyrin, and that ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) is the current research hotspot.Conclusion: Research on diazepam is flourishing. We identified research hotspots and trends in diazepam research using bibliometric and visual analytic methods. The clinical applications, mechanisms of action, pharmacokinetics, and assessment and management of the use of diazepam are the focus of current research and the development trend of future research.

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Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of the recent advances in diazepam from 2012 to 2021

Zhang

Kou²,

Qin³

et al. 2022

Front. Pharmacol.

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“…Antipyretic drugs do not reduce the recurrence of FSs in children with a history of FSs ( Lux, 2010 ). Diazepam in combination with acetaminophen reduced more seizure recurrences without serious adverse events compared with acetaminophen alone ( Tanaka et al, 2022 ). In most patients in whom a febrile illness leads to frequent recurrence of FSs, studies have evaluated the use of benzodiazepines as a bridging measure during a subsequent febrile episode for several days ( Printz et al, 2016 ; Guedj et al, 2017 ; Renda et al, 2020 ).…”

Section: Introduction Of Febrile Seizuresmentioning

confidence: 99%

The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms

You

Chen

2023

Front. Cell Dev. Biol.

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Febrile seizures (FSs) are convulsions caused by a sudden increase in body temperature during a fever. FSs are one of the commonest presentations in young children, occurring in up to 4% of children between the ages of about 6 months and 5 years old. FSs not only endanger children’s health, cause panic and anxiety to families, but also have many adverse consequences. Both clinical and animal studies show that FSs have detrimental effects on neurodevelopment, that cause attention deficit hyperactivity disorder (ADHD), increased susceptibility to epilepsy, hippocampal sclerosis and cognitive decline during adulthood. However, the mechanisms of FSs in developmental abnormalities and disease occurrence during adulthood have not been determined. This article provides an overview of the association of FSs with neurodevelopmental outcomes, outlining both the underlying mechanisms and the possible appropriate clinical biomarkers, from histological changes to cellular molecular mechanisms. The hippocampus is the brain region most significantly altered after FSs, but the motor cortex and subcortical white matter may also be involved in the development disorders induced by FSs. The occurrence of multiple diseases after FSs may share common mechanisms, and the long-term role of inflammation and γ-aminobutyric acid (GABA) system are currently well studied.

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Extraction and Quantification of Ano Rectal Formulation by UV-LC Techniques

Kumudhavalli,

S.,

Alexander

et al. 2023

RJPT

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Suppositories very popular formulations and are currently used therapeutically all over the world. Especially in pediatrics, where they can be used for the effective lowering of high fever accomplished with seizure. The choice of a suppository as the mode of drug delivery system in all cases even in infants when oral delivery is impossible, that is an unconscious or vomiting patient, or in the case of infants. Therefore, the quality control study of this dosage form with a modern instrumental analytical technique is highly desired. In consequence of the increased application of suppositories, there is a current demand for a rapid, effective analytical methods required for routine analysis. The literature search revealed that methods for the UV and high-performance liquid chromatography (HPLC) analysis of DZP are very rare.Thereforethe aim of the present research was to develop and validate a suitable general sample preparation and chromatography method for suppositories containing DZP. The primary method (I) is based on UV Spectroscopy. UV spectra of Diazepam are recorded. The secondary method is based on the Reverse phase HPLC method was developed. The UV detector was operated at 286nm. After method development the proposed method was validated as per ICH guidelines. The developed method was accurate and precise which shows the evident from the analytical data and recovery studies. The analytical results were in good and it complies with the label claims.

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Efficacy, safety, and economic impact of diazepam suppositories with as‐needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures

Cited by 3 publications

References 12 publications

A bibliometric analysis of the recent advances in diazepam from 2012 to 2021

A bibliometric analysis of the recent advances in diazepam from 2012 to 2021

The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms

Extraction and Quantification of Ano Rectal Formulation by UV-LC Techniques

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