Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease

Himoto, Takashi; Hosomi, Naoki; Nakai, S.; Deguchi, Akihiro; Kinekawa, Fumihiko; Matsuki, Michiko; Yachida, Mikage; Masaki, Tsutomu; Kurokochi, Kazutaka; Watanabe, Seishiro; Senda, Shoichi; Kuriyama, Shigeki

doi:10.1080/00365520701272409

Cited by 51 publications

(41 citation statements)

References 42 publications

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“…Oral administration of zinc significantly decreased serum levels of aminotransferese in patients with chronic hepatitis C by antioxidant effect [30]. Similarly, in our study, ALT levels significantly decreased at 6 months after beginning of therapy compared to baseline, and ALT levels remained unchanged untill the end of therapy, after which a mild elevation was observed at 6 months after completion of therapy.…”

Section: Responderssupporting

confidence: 53%

Interferon-Alpha-2a and Zinc Combination Therapy in Children with Chronic Hepatitis B Infection

Kuloğlu

Kırbaş

Erden

et al. 2011

Biol Trace Elem Res

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Zinc has been reported to enhance the response to interferon (IFN) or PEG-IFN plus ribavirin therapy, improve liver function, and ameliorate hematologic side effects in patients with chronic hepatitis C. However, the role of zinc supplementation during IFN therapy in chronic hepatitis B infection (CHB) remains unclear. We therefore aimed to report the results of zinc and IFN-alpha-2a therapy in children with CHB. Twenty-two naive, HBeAg-positive children (mean age 10.4 ± 4.4 years) received IFN-α2a (9 MU/m(2) sc) for 6 months plus peroral zinc (7.5 mg/day for <10 years and 10 mg/day for >10 years) for 12 months. Serum zinc, alanine aminotransferase (ALT), complete blood count, hepatitis B virus DNA (HBV DNA), and serological markers were measured. Histological (HR) and sustained response (SR) were evaluated at 6 months after completion of therapy. Normalization of ALT, HBeAg seroconversion, and HBV DNA < 10,000 copies/ml were considered as SR. HR was defined as decrease in Knodell histological activity index (HAI) score by at least 2 points compared to baseline. End of therapy ALT level and log HBV DNA were significantly lower than pretherapy levels (p = 0.001 and p = 0.001, respectively), while zinc level was not different. Portal inflammation score significantly decreased after therapy (p = 0.043), however, total HAI and other HAI components were not different. SR and HR were 25% and 52.9%. In conclusion as a first study investigating the effect of zinc and IFN combination therapy in children with CHB, SR and HR rates were not better than previously reported monotherapy or combination therapies.

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Section: Responderssupporting

confidence: 53%

Interferon-Alpha-2a and Zinc Combination Therapy in Children with Chronic Hepatitis B Infection

Kuloğlu

Kırbaş

Erden

et al. 2011

Biol Trace Elem Res

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“…The molecular mimicry between HCV NS5 and CYP2E1 may initiate the humoral response to CYP2E1 in those patients [103]. CH-C patients with circulating antibodies to CYP2E1 had more severe necroinflammation in the liver than CH-C patients without antibodies to CYP2E1 [102], as usually did CH-C patients seropositive for ANA [104].…”

Section: ) Clinical Significance Of Autoimmunity In Liver Diseases Amentioning

confidence: 99%

Relationship between Autoimmunity and Cancer or Metabolic Abnormality in Liver Diseases

Himoto¹,

Nishioka²,

Masaki³

2014

TOAUTOJ

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Recent advances in the serological analysis of recombinant cDNA expression libraries and proteomic analysis have enabled the identification of numerous kinds of novel autoantigens, especially tumor-associated antigens (TAAs). The emergence of antibodies to TAAs might imply that an autoimmune response was involved in the malignant transformation. These autoantibodies to TAAs often have predictive value as well as diagnostic relevance. Similarly, the relationship between autoimmunity and metabolic abnormalities, including insulin resistance and hepatic steatosis, has been also documented. Metabolic abnormalities are frequently associated with autoimmune diseases. In contrast, autoimmune reactions were occasionally involved in the process of metabolic dysregulation. This review primarily focuses on the current trends for the relationship between autoimmunity and cancer or metabolic abnormalities in liver disease and the current interpretations of autoantibodies in those diseases.

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“…We previously revealed the inverse correlation between the stages of hepatic fibrosis and serum Zn levels in hepatitis C virus (HCV)-related chronic liver disease [7,8]. Moreover, Zn deficiency has been associated with insulin resistance in patients with chronic hepatitis C [8].…”

Section: Introductionmentioning

confidence: 98%

Contribution of Zinc Deficiency to Insulin Resistance in Patients with Primary Biliary Cirrhosis

Himoto

Yoneyama

Kurokochi

et al. 2011

Biol Trace Elem Res

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The relationship between metabolic abnormalities of trace elements and insulin resistance has been established. Recent studies have revealed that insulin resistance is associated with autoimmune responses. The purpose of this study was to examine the correlation between zinc or copper metabolism and insulin resistance in patients with primary biliary cirrhosis (PBC). Sixteen patients with PBC were divided into two groups: early and advanced stage disease. The overall value of the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with advanced stage PBC was significantly higher than that in patients with early stage PBC, although the mean value in advanced stage PBC was significantly lower than that in hepatitis C virus (HCV)-related liver cirrhosis. There was an inverse correlation between serum zinc concentrations and HOMA-IR values in patients with PBC, while we found no correlation between serum copper levels and HOMA-IR values. HOMA-IR values were inversely associated with peripheral platelet counts, indicating the relationship between insulin resistance and hepatic fibrosis. These results suggest that zinc deficiency plays important roles of insulin resistance and subsequent hepatic fibrosis in patients with PBC, although insulin resistance in advanced stage PBC was significantly milder than that in HCV-related liver cirrhosis.

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Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease

Abstract: These findings suggest that polaprezinc exerts an anti-inflammatory effect on the liver in patients with HCV-related CLD by reducing iron overload.

Cited by 51 publications

References 42 publications

Interferon-Alpha-2a and Zinc Combination Therapy in Children with Chronic Hepatitis B Infection

Interferon-Alpha-2a and Zinc Combination Therapy in Children with Chronic Hepatitis B Infection

Relationship between Autoimmunity and Cancer or Metabolic Abnormality in Liver Diseases

Contribution of Zinc Deficiency to Insulin Resistance in Patients with Primary Biliary Cirrhosis

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