Contribution of Zinc Deficiency to Insulin Resistance in Patients with Primary Biliary Cirrhosis

Himoto, Takashi; Yoneyama, Hirohito; Kurokochi, Kazutaka; Inukai, Michio; Masugata, Hisashi; Goda, Fuminori; Haba, Reiji; Watanabe, Seishiro; Senda, Shoichi; Masaki, Tsutomu

doi:10.1007/s12011-011-9049-2

Cited by 12 publications

(4 citation statements)

References 37 publications

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“…Serum Zn levels are gradually decreased as the hepatic fibrosis develops in those patients. Advanced-stage PBC patients also have higher insulin resistance, suggesting that Zn deficiency may exacerbate insulin resistance in such patients [ 67 ].…”

Section: Association Between Zn Metabolism and Its Metabolic Abnormentioning

confidence: 99%

Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease

2018

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Zinc (Zn) is an essential trace element which has favorable antioxidant, anti-inflammatory, and apoptotic effects. The liver mainly plays a crucial role in maintaining systemic Zn homeostasis. Therefore, the occurrence of chronic liver diseases, such as chronic hepatitis, liver cirrhosis, or fatty liver, results in the impairment of Zn metabolism, and subsequently Zn deficiency. Zn deficiency causes plenty of metabolic abnormalities, including insulin resistance, hepatic steatosis and hepatic encephalopathy. Inversely, metabolic abnormalities like hypoalbuminemia in patients with liver cirrhosis often result in Zn deficiency. Recent studies have revealed the putative mechanisms by which Zn deficiency evokes a variety of metabolic abnormalities in chronic liver disease. Zn supplementation has shown beneficial effects on such metabolic abnormalities in experimental models and actual patients with chronic liver disease. This review summarizes the pathogenesis of metabolic abnormalities deriving from Zn deficiency and the favorable effects of Zn administration in patients with chronic liver disease. In addition, we also highlight the interactions between Zn and other trace elements, vitamins, amino acids, or hormones in such patients.

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Section: Association Between Zn Metabolism and Its Metabolic Abnormentioning

confidence: 99%

Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease

2018

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“…In the field of autoimmune liver disease, insulin resistance is commonly observed in patients with AIH [60] and PBC [61]. The phenomena may explain that insulin resistance contributes to the development of autoimmune liver disease.…”

Section: Autoantibodies In Sera Of Patients With Liver Disease Associmentioning

confidence: 99%

Relationship between Autoimmunity and Cancer or Metabolic Abnormality in Liver Diseases

Himoto¹,

Nishioka²,

Masaki³

2014

TOAUTOJ

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Recent advances in the serological analysis of recombinant cDNA expression libraries and proteomic analysis have enabled the identification of numerous kinds of novel autoantigens, especially tumor-associated antigens (TAAs). The emergence of antibodies to TAAs might imply that an autoimmune response was involved in the malignant transformation. These autoantibodies to TAAs often have predictive value as well as diagnostic relevance. Similarly, the relationship between autoimmunity and metabolic abnormalities, including insulin resistance and hepatic steatosis, has been also documented. Metabolic abnormalities are frequently associated with autoimmune diseases. In contrast, autoimmune reactions were occasionally involved in the process of metabolic dysregulation. This review primarily focuses on the current trends for the relationship between autoimmunity and cancer or metabolic abnormalities in liver disease and the current interpretations of autoantibodies in those diseases.

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“…PBC patients positive for the orcein stain in the liver specimens had higher total bilirubin and alkaline phosphatase levels than those negative for the orcein stain [ 145 ]. In addition, the serum Zn level of PBC patients gradually decreased as the clinical stage became more severe [ 146 ].…”

Section: The Roles Of Trace Elementsmentioning

confidence: 99%

Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases

Himoto

Masaki

2020

Nutrients

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Essential trace elements play crucial roles in the maintenance of health, since they are involved in many metabolic pathways. A deficiency or an excess of some trace elements, including zinc, selenium, iron, and copper, frequently causes these metabolic disorders such as impaired glucose tolerance and dyslipidemia. The liver largely regulates most of the metabolism of trace elements, and accordingly, an impairment of liver functions can result in numerous metabolic disorders. The administration or depletion of these trace elements can improve such metabolic disorders and liver dysfunction. Recent advances in molecular biological techniques have helped to elucidate the putative mechanisms by which liver disorders evoke metabolic abnormalities that are due to deficiencies or excesses of these trace elements. A genome-wide association study revealed that a genetic polymorphism affected the metabolism of a specific trace element. Gut dysbiosis was also responsible for impairment of the metabolism of a trace element. This review focuses on the current trends of four trace elements in chronic liver diseases, including chronic hepatitis, liver cirrhosis, nonalcoholic fatty liver disease, and autoimmune liver diseases. The novel mechanisms by which the trace elements participated in the pathogenesis of the chronic liver diseases are also mentioned.

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Contribution of Zinc Deficiency to Insulin Resistance in Patients with Primary Biliary Cirrhosis

Cited by 12 publications

References 37 publications

Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease

Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease

Relationship between Autoimmunity and Cancer or Metabolic Abnormality in Liver Diseases

Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases

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