Efficacy of yeast derived glucomannan or algae-based antioxidant or both as feed additives to ameliorate mycotoxicosis in heat stressed and unstressed broiler chickens

Bortoluzzi, Cristiano; Schmidt, J.; Bordignon, Heloísa Laís Fialkowski; Fülber, L. M.; Layter, Jonas Rodrigo; Fernandes, Jovanir Inês Müller

doi:10.1016/j.livsci.2016.09.005

Cited by 19 publications

(12 citation statements)

References 26 publications

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“…In this study, the morphology of the intestinal tract was severely damaged, with shorter VH and deeper CD by heat exposure on day 35, which was in accordance with the report by Song et al 27 It is reported that broilers exposed to heat stress may show intestinal ischemia and reduced intestinal integrity, leading to lower digestibility. 28 The results demonstrated that the impaired intestinal mucosa might be the subsequent stress besides inhibited appetite or because of that the ADG of the HS group was decreased compared with the PF group. However, there was no significant difference in VH and CD between the HS and NC groups on day 42.…”

Section: Discussionmentioning

confidence: 92%

Effects of chronic heat exposure on growth performance, intestinal epithelial histology, appetite‐related hormones and genes expression in broilers

et al. 2018

J Sci Food Agric

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Section: Discussionmentioning

confidence: 92%

Effects of chronic heat exposure on growth performance, intestinal epithelial histology, appetite‐related hormones and genes expression in broilers

et al. 2018

J Sci Food Agric

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“…Diatomaceous earth has an intermediary binding ability to mycotoxins according to the review prepared by Huwig et al [29], but its adsorbability is relatively high among mineral sources and it is among the ones with the highest adsorbability considering Fusarium toxins. The last component of CYC, kelp meal, may present antioxidant properties, being able to improve growth performance in broilers challenged with mycotoxins [33], as well as in pigs challenged with E. coli [34].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Mycotoxin Detoxifiers on Health and Growth of Newly-Weaned Pigs under Chronic Dietary Challenge of Deoxynivalenol

Holanda

Kim

2020

Toxins

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The efficacy of yeast-based mycotoxin detoxifiers on health and growth performance of newly-weaned pigs (27-d-old) fed diets naturally contaminated with deoxynivalenol was investigated. Sixty pigs were individually assigned to five treatments for 34 d: NC (negative control, 1.2 mg/kg of deoxynivalenol); PC (positive control, 3.2 mg/kg of deoxynivalenol); CYC (PC + clay/yeast culture-based product, 0.2%); CYE (PC + clay/yeast cell wall/plant extracts/antioxidants-based product, 0.2%); and CYB (PC + clay/inactivated yeast/botanicals/antioxidants-based product, 0.2%). Blood and jejunal mucosa were sampled, and data were analyzed using Proc Mixed of SAS with pre-planned contrasts. Deoxynivalenol reduced the average daily gain (ADG) in phase 3. Pigs fed CYC had greater overall ADG, average daily feed intake during phase 3, and gain to feed ratio during phase 2 than PC. At d 14, deoxynivalenol reduced blood urea nitrogen/creatinine and tended to reduce blood urea nitrogen. Pigs fed CYB tended to have greater aspartate aminotransferase than PC. At d 34, pigs fed CYC and CYB tended to have lower serum creatine phosphokinase than PC. Pigs fed CYE had lower blood urea nitrogen/creatinine than PC. In jejunal mucosa, deoxynivalenol tended to increase malondialdehydes and decrease glutathione. Pigs fed CYE and CYB had lower malondialdehydes, pigs fed CYB had greater glutathione and tended to have lower immunoglobulin A than PC. Pigs fed CYC and CYE tended to have lower interleukin 8 than PC. In summary, deoxynivalenol challenge (1.2 vs. 3.2 mg/kg) mildly compromised growth performance and increased the oxidative stress of pigs. Mycotoxin detoxifiers could partially overcome deoxynivalenol toxicity enhancing liver health, whereas CYE and CYB reduced oxidative stress, and CYC and CYB reduced immune activation. In conclusion, yeast-based detoxifiers with functional components as clay/inactivated yeast/botanicals/antioxidants had increased detoxifying properties in newly-weaned pigs challenged with deoxynivalenol, potentially by enhancing adsorbability, immune function, gut health, and reducing oxidative stress.

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“…It has been reported that chronic heat stress damaged the 35-day aged broiler intestinal morphology 5 . In addition, heat stress leading to intestinal ischemia and impairments of intestinal morphology in broiler 45 . Intestinal integrity regulates the intestinal tight junction, as well as influences the immune system 46 .…”

Section: Discussionmentioning

confidence: 99%

Chronic heat stress regulates the relation between heat shock protein and immunity in broiler small intestine

Siddiqui

Kang

Park

et al. 2020

Sci Rep

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Chronic heat stress is considered to decrease the immune functions which makes negative effect on broiler growth performance. Here, we investigated the relationship between chronic heat stress, growth performance, and immunity in the small intestine of broilers. The study included two groups (control and heat stressed group) with eight replications per group. Ten broilers of 20-day aged were allocated in each replication. On day 35, the treatment group was subdivided into two groups based on their body weights (heavy and low body weight). Although, there was only the control and treatment group on day 28. The growth performance decreased and expression of heat shock protein 70 (HSP70), HSP60, and HSP47 increased on days 28 and 35 in the chronic heat stress group as compared with those in the control group. The expression levels of HSPs were significantly higher in the low body weight group than in the control group. The genes HSP70 and HSP60 were significantly associated with pro- and anti-inflammatory cytokines in the small intestine of the broilers of the treatment group. Thus, HSP70 and HSP60 activated the adaptive immunity in the small intestines of the broilers from the treatment group to allow adaptation to chronic heat stress environment.

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Efficacy of yeast derived glucomannan or algae-based antioxidant or both as feed additives to ameliorate mycotoxicosis in heat stressed and unstressed broiler chickens

Cited by 19 publications

References 26 publications

Effects of chronic heat exposure on growth performance, intestinal epithelial histology, appetite‐related hormones and genes expression in broilers

Effects of chronic heat exposure on growth performance, intestinal epithelial histology, appetite‐related hormones and genes expression in broilers

Efficacy of Mycotoxin Detoxifiers on Health and Growth of Newly-Weaned Pigs under Chronic Dietary Challenge of Deoxynivalenol

Chronic heat stress regulates the relation between heat shock protein and immunity in broiler small intestine

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