Efficacy of xanthan based chlorhexidine gel as an adjunct to scaling and root planing in treatment of the chronic periodontitis

Abstract

Aim:The aim of this study was to evaluate the clinical effectiveness of locally delivered xanthan-based Chlosite® gel as an adjunctive therapy to scaling and root planing in treatment of chronic periodontitis.Materials and Methods:In a randomized controlled clinical study, 30 patients were selected. Pocket depth between 5 and 7 mm was selected and each patient had two sites on the same side of the mouth. A total of 30 control sites were scaled and root planed and 30 test sites were scaled and root planed and Chlosite® gel was added. The clinical parameters, probing depth (PD), clinical attachment level (CAL), plaque index (PI) and bleeding on probing (BOP), gingival index were recorded at baseline, 6 weeks, 3 months and 6 months.Statistical Analysis:Paired/unpaired t-test was used, significance was placed at 5% level of significance, i.e., P < 0.05 was considered as a significant.Results:From baseline to a period of 6 months, significant difference was found between test and control group for PD, CAL, PI and BOP, P value being PD (P = 0.002), CAL index (P = 0.014), respectively.Conclusion:Subgingival injection of xanthan-based Chlosite® gel adjunct with scaling and root planing appeared to cause significant improvement compared with scaling and root planing alone in persons with chronic periodontitis.

Adjunctive Subgingival application of Chlorhexidine gel in nonsurgical periodontal treatment for chronic periodontitis: A systematic review and meta-analysis

“…A significant improvement in PPD and/or CAL was reported in a number of studies using XAN-CHX gel 26,27,29,[31][32][33][34] . Whereas, several studies showed no additional benefit in clinical outcomes with the adjunctive use of CHX gel [8][9][10]25,28,30 . In addition, all three studies using CHX gels that did not contain Xanthan gum reported no clinical benefits in the test group [8][9][10] .…”

“…Seventeen articles met the criteria and were included for qualitative analysis. Thirteen studies reported subgingival application of CHX gel adjunct to SRP at selected sites with a moderate to deep probing depth (at least 4mm in all studies) [8][9][10][25][26][27][28][29][30][31][32][33][34] . Nine studies were split-mouth RCTs 8,10,[26][27][28][31][32][33][34] , four were parallel RCTs 9,25,29,30 and three studies used a placebo in the control 10,30,32 .…”

“…Thirteen studies reported subgingival application of CHX gel adjunct to SRP at selected sites with a moderate to deep probing depth (at least 4mm in all studies) [8][9][10][25][26][27][28][29][30][31][32][33][34] . Nine studies were split-mouth RCTs 8,10,[26][27][28][31][32][33][34] , four were parallel RCTs 9,25,29,30 and three studies used a placebo in the control 10,30,32 . From the 13 papers, 10 showed the clinical outcomes of adjunctive subgingival delivered Xanthan-based CHX gel (XAN-CHX gel) in SRP and SRP alone [25][26][27][28][29][30][31][32][33][34] ; CHX concentration in the XAN-CHX gel was 1.5% in nine studies and 2.5% in one study 33 , and another three studies reported the use of gels containing 0.5%, 1% and 2% CHX without Xanthan gum [8][9][10] .…”

“…Overall, for all 17studies, six were assessed to have a low risk of bias 8,16,17,25,28,30 , two were judged as an unclear risk of bias 10,32 , nine were considered to have a high risk of bias 9,18,19,26,27,29,31,33,34 and six were excluded from the quantitative analysis 9,26,27,29,31,34 . The summary of quality assessment is showed in Table 2.…”

Attenuation of Intestinal Efflux Pump thru Polymers and Preservatives

“…Several papers have described information on the noteworthy properties of different excipients which affect on drug absorption and permeability thru intestinal efflux pump. Such as, a previous study reported that tween 80 can shrink the fraction of serosal-mucosal transport to mucosal-serosal transport for Rho-123 through rat jejunal membrane in vitro and caco-2 cell monolayer evocative of p-gp inhibition [13]. Into the bargain, the in vitro amount of absorption for digoxin through a rat gut sac (a p-gp substrate) revealed an intense growth in amounts after treating with 0.5% (w/v) tween 80 and tween 20 [14].…”