Xanthan Gum for Regenerative Medicine

Souza, Renata Francielle Bombaldi de; Souza, Fernanda Carla Bombaldi de; Westin, Cecília Buzatto; Barbosa, Rafael Maza; Moraes, Ângela Maria

doi:10.1007/978-3-030-35734-4_59-1

Cited by 1 publication

(1 citation statement)

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“…X is a biocompatible polymer and is not cytotoxic It shows mucoadhesive capacity in the oral cavity, being up to 3.6 times more mucoadhesive than chitosan [ 17 ]. Due to its high aqueous retention capacity, X can be a relevant component of formulations in the form of gels with the application as drug delivery systems for the treatment of diseases that affect the oral cavity, particularly for periodontitis [ 18 ]. Chitosan is another non-cytotoxic natural polymer widely used in tissue engineering and combined with HA for bone tissue regeneration [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Cell-Friendly Chitosan-Xanthan Gum Membranes Incorporating Hydroxyapatite Designed for Periodontal Tissue Regeneration

Barbosa

Rocha²,

Souza

et al. 2023

Pharmaceutics

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In this work, a simple method was proposed to produce dense composite polysaccharide-based membranes to be used for guided tissue and guided bone regeneration. The mucoadhesive polysaccharides chitosan (C) and xanthan gum (X) were used to produce polyelectrolyte-based complex membranes. Hydroxyapatite (HA) was added to the formulation as a potential drug carrier, in C:X:HA mass proportions equal to 1:1:0.4, 1:1:2, and 1:1:10, and also to improve membranes bioactivity and biomimetic properties. FTIR analysis indicated successful incorporation of HA in the membranes and XRD analysis showed that no changes in the HA crystalline structure were observed after incorporation. The residual mass evaluated by TGA was higher for the formulation produced at the proportion 1:1:10. The membranes produced showed asymmetrical surfaces, with distinct roughness. Increasing the HA concentration increased the surface roughness. Greater in vitro proliferation of dental pulp mesenchymal stem cells was observed on the surface of the membrane with 1:1:10 C:X:HA proportion. However, the 1:1:2 formulation showed the most adequate balance of mechanical and biological properties. These results suggest that adding HA to the membranes can influence mechanical parameters as well as cell adhesion and proliferation, supporting the potential application of these materials in regenerative techniques and the treatment of periodontal lesions.

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Section: Introductionmentioning

confidence: 99%