Efficacy of whitening toothpaste containing blue covarine: A double‐blind controlled randomized clinical trial

Abstract

Objective: This randomized clinical trial evaluated the efficacy and safety of a blue-covarine whitening toothpaste on tooth bleaching. Subjects and methods: Seventy-five subjects with shade mean C1 or darker were randomized into three groups (n = 25): CT-conventional toothpaste, WT-whitening toothpaste, and CP10-10% carbamide peroxide. Subjects from CT and WT brushed their teeth twice/day for 2 weeks. CP10 used bleaching gel for 4 hours/night for 2 weeks. Tooth shade and CIELab parameters were measured at baseline, after the first application, 2-and 4-week. ΔE* ab and ΔE 00 were calculated. Subjects' perception about tooth color appearance, tooth sensitivity (TS), and gingival irritation (GI) were also assessed. Results: At all evaluation periods, it was not observed differences between WT and CT considering tooth shade (P > 0.7) or CIELab parameters (P > 0.3). At 2-and 4-week, ΔE* ab and ΔE 00 were higher for CP10 than WT or CT (P = 0.001). WT and CT reported major dissatisfaction with tooth color appearance than CP10 (P = 0.001). At 1-and 2-week, WT experienced GI and TS similar to CT, both lower than CP10 (P < 0.01). Conclusion: There were no significant differences in the whitening efficacy between whitening and conventional toothpastes. Neither of the dentifrices was as effective as at-home bleaching. Clinical significance: The silica-based toothpaste containing blue covarine evaluated in this study did not give significant tooth whitening benefits over 2 weeks of use. K E Y W O R D S clinical trial, tooth bleaching, tooth discolouration, toothpastes 1 | INTRODUCTION Tooth bleaching is still the most requested treatment in dental offices because it has been considered an effective and conservative way for tooth whitening. 1,2 However, the side effects frequently related to athome or in-office bleaching techniques are the gingival irritation and/or tooth sensitivity. 3,4 To promote the same benefits achieved with these techniques with lower incidence of adverse effects, several companies have developed and improved the over-the-counter (OTC) at-home bleaching products to make the treatment more accessible and to meet patients expectations. 5-8 The OTC products usually contain low levels of hydrogen peroxide (2%-6%) and include gels, rinses, gum, toothpastes, whitening strips, or paint-on films. 9-11 The action mechanisms of the OTC products are based on the bleaching of intrinsic stains using oxidizing agents to break down the organic molecules of pigments present in the teeth, and the control and removal of extrinsic stains through the abrasive agents. 12-14 Whitening toothpastes, which represent more than 50% of the OTC products, often contain optimized abrasives that may be associated to enzymes, surfactants, hydrogen peroxide (limited to about 1 wt%),

Investigation of surface roughness values of various restorative materials after brushing with blue covarine containing whitening toothpaste by two different methods: AFM and profilometer

“…The increasing interest in the aesthetic benefits that can be obtained from dental treatment has contributed to the development of a wide variety of teeth whitening treatment products and technologies that will meet the expectations and demands. (Kielbassa, Maier, Gieren, & Eliav, 2015; Meireles, de Sousa, Lins, & Sampaio, 2021).…”

“…Furthermore, the daily utilization of these abrasives modifies the surface of enamel and resin restorations in the mouth, decreasing the adhesion of dental plaque, food debris and chromophores, reducing tooth pigmentation, and changing its discoloration (Joiner, 2010; Vaz et al, 2019). As a new development in teeth whitening, apart from the abrasive cleaning system, using optical principles silica‐based toothpaste containing blue covarine pigment has developed (Meireles et al, 2021).…”

“…meet the expectations and demands. (Kielbassa, Maier, Gieren, & Eliav, 2015;Meireles, de Sousa, Lins, & Sampaio, 2021).…”

Blue Covarine Toothpaste versus Office Whitening: Which is the Most Effective on Stained Teeth?

“…33 Recent clinical evidence supports the scarce whitening potential of toothpaste containing blue covarine after a single application 34 or even after using it for 2 weeks. 35 On the other hand, the use of BC toothpaste after in-office whitening has proven to be an effective strategy to maintain the whitening results. 36 This can be attributed to the possible synergism between BC and HP.…”

Effectiveness and Adverse Effects of Over-the-Counter Whitening Products on Dental Tissues

“…Finally, a few products can present in their composition a dye called Blue Covarine, which acts based on an optical approach, modifying the visual perception of tooth color by creating more light scattering, shifting the reflected color of the teeth from yellow to blue, thus creating an illusion of greater luminosity (55)(56)(57). In vitro findings suggest effective stain removal and whitening using dentifrices with Blue Covarine ( 36), but a recent clinical trial comparing a dentifrice with this dye to a control one (non-whitening) found no color improvement after a 4week period (58). The authors discussed that the Blue Covarine was able to reduce yellowness (b * parameter -CIE Lab system) after a 2-week daily treatment, with two daily applications, but this reduction did not remain stable, indicating the need for the constant application of this product to achieve acceptable results.…”