Efficacy of transfusion of platelet concentrates obtained by manual pooling or by semiautomated pooling of buffy‐coats: a retrospective analysis of count increment, corrected count increment and transfusion interval

Abstract

There are no significant differences between the two preparation methods regarding the clinical outcome of platelet transfusions, as the difference in 1-h CI is explained by differences in platelet content.

Quality assessment of buffy‐coat‐derived leucodepleted platelet concentrates in PAS‐plasma, prepared by the OrbiSac or TACSI automated system

“…Platelets are known to be affected during preparation and storage under blood banking conditions, in a complex process referred to as platelet storage lesion . Several studies have analysed the quality of BC‐derived PCs prepared manually and with OrbiSac , while there is scarce information on PCs prepared with TACSI . The aim of this study was to evaluate the effect of using OrbiSac or TACSI on the in vitro quality of PCs during storage under standard conditions for up to 5 days.…”

Therapeutic efficacy of platelet transfusion in patients with acute leukemia: an evaluation of methods

“…The clinical effect of PLT transfusion is monitored by measures of PLT viability and functionality. In studies of thrombocytopenic patients, PLT viability is usually investigated by immediate PLT count increments, reflecting the PLT recovery together with late PLT count increment and intertransfusion interval (ITI) which reflects the PLT survival 4,5,9‐12 . PLT functionality may be monitored by bleeding assessments 12,13 and point‐of‐care tests of hemostasis and PLT function like the thromboelastography (TEG) analysis 14 .…”

“…In studies of thrombocytopenic patients, PLT viability is usually investigated by immediate PLT count increments, reflecting the PLT recovery together with late PLT count increment and intertransfusion interval (ITI) which reflects the PLT survival. 4,5,[9][10][11][12] PLT functionality may be monitored by bleeding assessments 12,13 and point-of-care tests of hemostasis and PLT function like the thromboelastography (TEG) analysis. 14 While PLT count increments are fundamental in the prophylactic PLT transfusion strategy, the therapeutic transfusion strategy is based on bleeding assessments.…”

Comparison between the clinical efficacy of platelet concentrates, derived from buffy coat and apheresis in tumor patients

“…The patients all showed good haemostatic capacity while group II was more likely to suffer from allergic reactions. Earlier findings, however, showed no difference between the two types of PCs according to clinical efficacy (17). …”