Efficacy of trans-2-Hydroxycinnamic acid against Trichlorfon-induced oxidative stress in wistar rats

Sharma, Poonam; Singh, Rambir

doi:10.4103/0971-6580.103671

Cited by 17 publications

(6 citation statements)

References 27 publications

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“…In the present study, dietary EAE recovered the activity of SOD and the content of GSH in the hepatopancreas and intestine of carp, which were decreased following trichlorfon exposure. This result was in good harmony with the reports that exposure to trichlorfon decreases SOD activity in giant freshwater prawn (Chang et al, 2006) and GSH content in wistar rats (Sharma & Singh, 2012), and EAs inhibit the doxorubicin-induced decrease in the activity of SOD in the hearts of mice (Xin et al, 2007). The intracellular GSH are usually kept at high levels through the reduction of oxidized GSH (GSSG) to GSH by GR (Chen, Zhou, Feng, Liu, & Jiang, 2009).…”

Section: Dietary Eae Prevented the Trichlorfon-induced Oxidative Dasupporting

confidence: 88%

“…In this study, dietary EAE recuperated GR and GST activities in the hepatopancreas and intestine of carp, which were decreased by trichlorfon exposure. This was in good harmony with the reports that exposure to trichlorfon reduces the activity of GR in the liver, kidney, and brain of Wistar rats (Sharma & Singh, 2012) and induces GST depletion in the hearts of Nile tilapia (Thomaz et al, 2009). However, the information regarding the effects of active ingredients.…”

Section: Dietary Eae Prevented the Trichlorfon-induced Oxidative Dasupporting

confidence: 85%

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The extracts of Angelica sinensis restore the digestive and absorptive capacity through improving antioxidant status in digestive organs of fish treated with trichlorfon

Jiang

et al. 2018

Aquac Res

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Firstly, a linoleic acid emulsion and fish hepatopancreas homogenate were incubated with ethoxyquin and the extracts of Angelica sinensis. The results demonstrated that ethoxyquin showed the strongest protective effects against lipid oxidation of all of the examined compounds (p < 0.05). However, ethyl acetate extract of Angelica sinensis at high concentrations showed a stronger effect on lipid oxidation than that of ethoxyquin (p < 0.05). Next, seven experimental diets that contained 0.0, 1.0, 2.0, 3.0, 4.0, 5.0, and 6.0 g/kg of ethyl acetate extract of Angelica sinensis were fed to seven groups of carp (Cyprinus carpio var. Jian) respectively. After 60 days, carp were exposed to 2.4 mg trichlorfon/L in water for 4 days. The results displayed that trichlorfon exposure increased the contents of malonaldehyde and protein carbonyl in digestive organs and the activities of glutamate-oxaloacetate and glutamate-pyruvate transaminase in plasma, and decreased feed intake, the level of reduced glutathione, and the activities of trypsin, chymotrypsin, lipase, alpha-amylase, Na + ,K + -ATPase, alkaline phosphatase, antisuperoxide anion, antihydroxyl radical, superoxide dismutase, glutathione reductase, and glutathione S-transferase in digestive organs of carp (p < 0.05). Moreover, the dietary ethyl acetate extract of Angelica sinensis prevented the decrease in the above parameters in carp treated with trichlorfon (p < 0.05). These results revealed that the dietary ethyl acetate extract of Angelica sinensis could quench the trichlorfon-induced structural and functional damage by improving the antioxidative capacity of the digestive organs of fish. Therefore, the extract of Angelica sinensis could be used as an inhibitor of trichlorfon stress in fish. K E Y W O R D SAngelica sinensis, digestion and absorption, lipid oxidation, oxidative damage, trichlorfon

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Section: Dietary Eae Prevented the Trichlorfon-induced Oxidative Dasupporting

confidence: 88%

Section: Dietary Eae Prevented the Trichlorfon-induced Oxidative Dasupporting

confidence: 85%

The extracts of Angelica sinensis restore the digestive and absorptive capacity through improving antioxidant status in digestive organs of fish treated with trichlorfon

Jiang

et al. 2018

Aquac Res

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“…S-Methyl-5'-thioadenosine is a metabolite that can influence the regulation of gene expression, proliferation, differentiation, and apoptosis 61 . Both 4-Hydroxycinnamic acid and trans-2-hydroxycinnamic acid were important sources of antioxidants 62,63 . Both theobromine and ajmalicine were regarded as vasodilators.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress

Gao

Liu

2020

Sci Rep

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Temperature fluctuation is a key abiotic factor for the growth and survival of Pacific abalone Haliotis discus hannai, particularly during climate change. However, the physiological mechanism underlying the abalones' response to heat stress remains unknown. We sought to understand the metabolic adaptation mechanism of Pacific abalone to heat stress for further analyzing its heat tolerance capacity. For two groups experienced different acclimate temperature (10 °C and 30 °C for 62 days), the Pacific abalone juveniles displayed significantly different survival rates under 31 °C acute heat treatment. A total of 1815 and 1314 differential metabolites were identified from the 10 °C and 30 °C acclimate groups respectively, by comparing mass spectrometry data of the samples before and after heat stimulation. Heat stress led to mitochondrial failure, resulting in incomplete oxidative metabolism of amino acids and fatty acids in the mitochondria, and massive accumulation of unstable metabolic intermediates in cells. The 10 °C acclimated group accumulated more harmful substances after heat stimulation, provoking further stress responses and pathophysiological processes. In comparison, the 30 °C acclimated group showed stronger regulation capacity to produce beneficial substances for metabolic homeostasis. The findings provided insight into the heat response of marine animals, especially concerning mitochondrial metabolism. Global warming will trigger more extreme weather events that can potentially be deleterious to marine animals, especially the ones distributed in the intertidal and neritic zones 1,2. Organisms inhabiting this range face higher water temperature elevations and more environmental fluctuations during the summer season. Aquaculture animals, which are subjected to fluctuations in natural conditions, are more vulnerable to these physical and chemical stimulations as they are usually stocked intensively at high density and rely on water influx from coastal areas 3. Even a slight change in the climate may cause enormous economic losses in mariculture. The analysis of thermal stress on aquaculture animals has thus gained more research interests 4-7. Pacific abalone Haliotis discus hannai, a cold water gastropod, is the predominantly farmed abalone species in many Asian countries 8. It is naturally distributed in cold water, implying that high temperatures would limit its southern expansion along the Asian coast. In recent years, the dominant aquaculture strategy in China is transferring juvenile abalones to warmer south China during the winter, thereby accelerating the animal's growth rate. In the meantime, the traditional genetic selection based on growth traits may contribute to a decreased heat stress tolerance of the organism. Consequently, the massive mortality in summer months has become a challenge that has led to an enormous economic loss in abalone and the entire molluscs industry in recent years 9. While some overwintering abalones were transferred back to the northern region during spring, some were c...

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“…Among those changed metabolites (Fig. 3 ), 2-hydroxycinnamic acid was reported to function as an antioxidant that can induce antioxidant response by increasing the levels of superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), glutathione reductase (GR), and glutathione (GSH) in the brain, liver, and kidney 19 . Tyrosine is used to synthesis protein.…”

Section: Discussionmentioning

confidence: 99%

Small molecule metabolite biomarkers for hepatocellular carcinoma with bile duct tumor thrombus diagnosis

Tan

Deng

et al. 2018

Sci Rep

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Hepatocellular carcinoma with bile duct tumor thrombus (BDTT) is a malignant disease. The most commonly used diagnosis methods for BDTT are MRCP/ERCP, ultrasonic diagnosis or CT scan. However, BDTT is often misdiagnosed as other bile duct diseases, such as extrahepatic cholangiocarcinoma (EHCC), choledochal cyst (Cyst) and common bile duct stone (Stone). Diagnostic methods, which are more accurate and less destructive, are urgently needed. In this paper, we analyzed the small molecule metabolites in the serum of BDTT, Stone, Cyst and EHCC patients and normal people using untargeted GC-MS, and identified 21 metabolites that show different levels among different samples. Using targeted UHPLC-QQQ-MS analysis, we found that several metabolites are significantly changed. ROC curve analysis revealed two metabolites, L-citrulline and D-aspartic acid, as potential biomarkers that can distinguish BDTT from other bile duct diseases.

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Efficacy of trans-2-Hydroxycinnamic acid against Trichlorfon-induced oxidative stress in wistar rats

Cited by 17 publications

References 27 publications

The extracts of Angelica sinensis restore the digestive and absorptive capacity through improving antioxidant status in digestive organs of fish treated with trichlorfon

The extracts of Angelica sinensis restore the digestive and absorptive capacity through improving antioxidant status in digestive organs of fish treated with trichlorfon

Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress

Small molecule metabolite biomarkers for hepatocellular carcinoma with bile duct tumor thrombus diagnosis

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