Efficacy of tranexamic acid in reducing blood loss after cesarean section

Sekhavat, Leila; Tabatabaii, Afsar; Dalili, Maryam; Farajkhoda, Tahmineh; Tafti, Atefah Dehghani

doi:10.1080/14767050802353580

Cited by 140 publications

(145 citation statements)

References 10 publications

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“…None of the babies required NICU admission. Results were comparable to previous studies [6,7,9,11,12].…”

Section: Discussionsupporting

confidence: 89%

“…Svanberg et al [10] reported 67 cases of abruptio placentae being treated by tranexamic acid without any signs of thrombosis in any. Similar results were found in other studies [6,7,9]. All data demonstrated that tranexamic acid can be used safely without increasing the occurrence of thrombosis, but still more studies are needed in this regard.…”

Section: Discussionsupporting

confidence: 89%

“…Sekhavat et al [9] conducted a prospective randomised study on 90 primipara mothers which showed that tranexamic acid significantly reduced blood loss from the end of caesarean section to 2 h post-partum; 28.02 ± 5.53 ml blood loss in the tranexamic group versus 37.12 ± 8.97 ml in the control group (p = 0.000). These results were comparable to our study although they studied only primipara, whereas our study had no inclusion criteria based on parity.…”

Section: Discussionmentioning

confidence: 99%

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Role of Intravenous Tranexamic Acid on Caesarean Blood Loss: A Prospective Randomised Study

Ray

Bhattacharya

Chakraborty

et al. 2016

J Obstet Gynecol India

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Background Post-partum haemorrhage (PPH) is a major cause of maternal mortality globally. Tranexamic acid, an anti-fibrinolytic agent, is a novel approach in an attempt to prevent this dreadful complication. This study aims to document the efficacy of intravenous (IV) tranexamic acid in reducing blood loss during and after caesarean section (CS). Methods In this prospective randomised placebo-controlled open-label study, 100 mothers scheduled for elective CS were randomly selected and divided into two groups (study and control) of 50 each. The study group received 1 g IV tranexamic acid and the control group received IV placebo. Following delivery, all mothers received ten units of oxytocin in 500 ml of normal saline.Results The mean intra-operative and post-partum blood loss were significantly lower in the study group than the control group: 499.11 ± 111.2 and 59.93 ± 12.5 ml versus 690.85 ± 198.41 and 110.06 ± 13.47 ml, respectively, (p \ 0.001). Total blood loss was 30 % less in the study group (p \ 0.001). Six mothers had PPH in the control group, while none in the study group. The difference between the pre-operative and post-operative haemoglobin levels was significantly less in the study group than the control group, 0.26 ± 0.22 versus 0.99 ± 0.48 g% (p \ 0.001).There was no significant difference with respect to other haematological parameters. There was no added adverse effect or need for NICU admission in the study group. Conclusion Pre-operative IV tranexamic acid significantly reduced blood loss during elective CS without any significant adverse effects.

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“…None of the babies required NICU admission. Results were comparable to previous studies [6,7,9,11,12].…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Intravenous Tranexamic Acid on Caesarean Blood Loss: A Prospective Randomised Study

Ray

Bhattacharya

Chakraborty

et al. 2016

J Obstet Gynecol India

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“…These results go in hand with that previously reported in literature concerning the prophylactic use of TXA; Gai et al [27] found intravenous TXA given immediately before CS statistically reduces the extent of bleeding from placental delivery to 2 h postpartum and its use was not associated with any side effects or complications. Sekhavat et al [28] also, found TXA statistically reduced blood loss from end to 2 h after CS and its use was not associated with any side effects or complications.…”

Section: Resultsmentioning

confidence: 99%

Role of Incisional infiltration with intraperitoneal instillation analgesia in non descent vaginal hysterectomy

Assar

Elmentawy

Mosaad

et al. 2018

Evidence Based Women's Health Journal

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Objective: To evaluate therapeutic yield of tranexamic acid (TXA) injection and fluid co-load on the outcome of cesarean section (CS) conducted under spinal anesthesia Study Design : Prospective randomized comparative study. Patients and Methods:The current included 174 primipara scheduled for elective CS under spinal anesthesia. Intravenous (IV) fluid co-load (15 ml/kg warm lactated ringer solution) started as fast drip during and continued after spinal anesthesia. Patients were randomly allocated into two equal groups: Group TXA received a loading IV dose of 500 mg TXA 20 minutes before surgery followed by continuous TXA infusion at rate of 1 mg/kg/min till end of surgery. Group C did not receive prophylactic TXA, but both groups received a booster dose of 2 gm TXA if required. Patients were monitored for the frequency and severity of hypotension and dose of ephedrine used. Amount of bleeding since skin incision till 2-hours postpartum (PP), the frequency of patients had stopped PP bleeding till 2-hr PP and the total dose of oxytocin drugs and booster doses of TXA were recorded. Results: Hypotension was recorded in 53 patients (30.5%); only 12 patients had blood pressure <80 mmHg. The lowest blood pressure, frequency of hypotension, time of occurrence and duration of hypotension and the used dose of ephedrine showed non-significant difference between both studied groups. The amount of perioperative bleeding was significantly lower in TXA group compared to control group. Twenty parturient had continued PP bleeding for more than 2 hours PP with significantly (p=0.038) lower frequency of bleeders in TXA group. All women had continued bleeding received booster doses of TXA with a significantly higher dose in control group compared to TXA group. Conclusion: Preoperative administration of TXA significantly reduced perioperative bleeding with significant reduction of consumption of TXA booster doses and utrotonics without affecting safety. Fluid coloading allowed reduction of the frequency and extent of hypotension concomitant with spinal anesthesia.

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“…In the present study also TXA significantly reduced puerperal bleeding in the women and Hb levels increased after treatment, although the increase was not significant. Sekhavat, et al [22] in their study used TXA immediately before CS in pregnant women and showed that bleeding was reduced until two hours after CS and the Hb levels at 24 hours after surgery were higher than control group [22]. Ferrer, et al [23] in their systematic review of using TXA to control PPH concluded TXA may reduce bleeding after delivery, but further studies are needed to prove this effect [23].…”

Section: Discussionmentioning

confidence: 99%

Comparing the Effects of Tranexamic Acid and Medroxyprogestrone on Puerperal Bleeding

Veisi¹,

Zangeneh²,

Rezavand³

et al. 2014

Journal of Women's Health and Gynecology

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Efficacy of tranexamic acid in reducing blood loss after cesarean section

Cited by 140 publications

References 10 publications

Role of Intravenous Tranexamic Acid on Caesarean Blood Loss: A Prospective Randomised Study

Role of Intravenous Tranexamic Acid on Caesarean Blood Loss: A Prospective Randomised Study

Role of Incisional infiltration with intraperitoneal instillation analgesia in non descent vaginal hysterectomy

Comparing the Effects of Tranexamic Acid and Medroxyprogestrone on Puerperal Bleeding

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