Several animal models are currently being used in the study of ocular allergy. These include different strains within the mouse, rat, guinea pig, rabbit and dog species. Continuing investigations are needed to elucidate the complex molecular and cellular processes involved in the pathogenesis of ocular allergies. A better understanding of the interplay of effector cells, cytokines, adhesion molecules and a number of other inflammatory mediators will broaden our knowledge of the pathophysiology of ocular allergy and allow improved therapeutic options for this disease.