Efficacy of topical ivermectin following exposure of treated cattle to rain

Rolfe, P.F.; Dawson, K. L.; Nichols, Greg; Webster, M.; Ryan, W. G.

doi:10.1136/vr.141.11.269

Cited by 8 publications

(6 citation statements)

References 3 publications

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“…Exposure to a simulated rainfall of approximately 12.5 mm during 30 min, classi®ed as a heavy shower (Anonymous 1983), shortly before or after treatment had no impact on the ecacy of Ivomec Pour-On. These data agree with the ®ndings of Rolfe et al (1997), who found >99% ecacy for topically applied ivermectin against Cooperia spp. and Ostertagia spp.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of the effect of simulated rainfall on the efficacy of Ivomec Pour-on against Cooperia spp. infection in cattle

Rehbein¹,

Barrick²,

Batty³

et al. 1999

Parasitology Research

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Four controlled studies, one each in Australia, Germany, the United Kingdom, and the United States, involving 30 calves each were conducted to evaluate the effect of simulated rainfall on the efficacy of Ivomec Pour-On against infections of Cooperia spp. At 3 weeks before treatment the calves were infected orally with third-stage larvae of Cooperia spp. In each study a recent, locally derived field isolate was used. The calves were allocated by restricted randomization based on body weight within sex to one of the following treatments: unmedicated control with no rain, Ivomec Pour-On with no rain, Ivomec Pour-On with rain starting at 40 min before treatment, Ivomec Pour-On with rain starting at 10 min after treatment, and Ivomec Pour-On with rain starting at 60 min after treatment. Ivomec Pour-On was applied topically at a dose rate of 1 ml/10 kg body weight (500 microg ivermectin/kg body weight). The simulated rainfall was equivalent to a heavy shower of approximately 12.5 mm of water during a 30-min period. The calves were necropsied for worm counting at 14 or 15 days after treatment. An evaluation of the pooled data showed that as compared with the untreated controls, the Ivomec Pour-On-treated calves with no rain had significantly (P < 0.01) fewer C. oncophora (> 99%), C. punctata (> 99%), C. surnabada (> 98%), and combined Cooperia spp. (> 99%). The reduction in Cooperia numbers noted for calves exposed to simulated rainfall was > 96% for all Cooperia species, regardless of when the rainfall started relative to the application of Ivomec Pour-On. There was no significant (P > 0.1) difference between the Ivomec Pour-On-treated calves with no rain and the pooled groups with simulated rainfall or between the group with rain before treatment and the pooled groups with rain after treatment. Ivomec Pour-On was highly effective against established infections of Cooperia spp. when applied to wet animals or to animals becoming wet shortly after treatment.

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Section: Discussionsupporting

confidence: 92%

Evaluation of the effect of simulated rainfall on the efficacy of Ivomec Pour-on against Cooperia spp. infection in cattle

Rehbein¹,

Barrick²,

Batty³

et al. 1999

Parasitology Research

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“…Skogerboe et al (1999) reported that pour on administration of Ivermectin during rain has more than 99% antiparasitic effect; and rain has no specific effect on reducing the role of Ivermectin (Rehbein et al, 1999;Skogerboe et al, 1999). Of course other studies on this subject have been done and indicated that during rain, pour on Ivermectin is active against parasites (Rehbein et al, 1999;Rolfe and Dawson, 1997;Skogerboe et al, 1999). In fact, pour on administration of Ivermectin is very easy for farmers and so far for Ivermectin administration, no specific side effect has been reported (Rehbein et al, 1999;Rolfe and Dawson, 1997;Skogerboe et al, 1999).…”

Section: Resultsmentioning

confidence: 99%

“…Of course other studies on this subject have been done and indicated that during rain, pour on Ivermectin is active against parasites (Rehbein et al, 1999;Rolfe and Dawson, 1997;Skogerboe et al, 1999). In fact, pour on administration of Ivermectin is very easy for farmers and so far for Ivermectin administration, no specific side effect has been reported (Rehbein et al, 1999;Rolfe and Dawson, 1997;Skogerboe et al, 1999). At the end, we can say Ivermectin is a very effective drug for controlling gastrointestinal parasites in ruminant and its use is very easy, with no need of specific tools.…”

Section: Resultsmentioning

confidence: 99%

The effect of Ivermectin pour-on administration against natural Nematodirus spathiger infestations and prevalent rate of that in cattle

Mirhadi¹,

Garedaghi²,

Saeid³

2011

Afr. J. Microbiol. Res.

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These days one of the real problems that cause the prejudice-economy in animal farms yearly is parasitic disease. For that reason and to prevent these problems the use of antiparasitic drugs is necessary. Ivermectin is a broad spectrum antiparasitic agent and is in different dosage forms such as injection, oral and pour-on. The aims of this study was to evaluate the efficacy of ivermectin pour-on administration against natural Nematodirus spathiger nematode infections in cattle and also to determine the prevalent rate of this parasite in Tabriz area. In this study, 120 heads of male and female hybrid cattle were used for LPG (larves per gram of feces) feces test. Willis method was applied for feces test and Stoll method was used for counting nematode larvae (LPG). After confirming worm contamination and counting N. spathiger nematode larves in feces in infected animals, ivermectin (0.5 mg/kg) pour-on was administrated. Feces test was repeated in 1, 7, 21 and 28 days after treatment. Results showed that total prevalence of N. spathiger nematode infections was 33.33% in cattle of Tabriz area. The effects of ivermectin pour-on on N. spathiger nematode were 13.37, 44.96, 83.69 and 99.1% in 1, 7, 21 and 28 days respectively. In conclusion, because the effect of this drug against N. spathiger nematode was >99% (p<0.05), cattle can use this drug in anti-parasitic programme. Of course, the effect of this drug on other nematodes and parasitic infections need more investigation.

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“…In a few studies available in the literature, the effects of different environmental conditions on the efficacy of endectocides were investigated following pour‐on administration in cattle. It has been indicated that IVM and doramectin were efficacious against nematodes in cattle following pour‐on administration before or after simulated rain (Rolfe et al. , 1997; Rehbein et al.…”

Section: Mean (±Sd) Pharmacokinetic Parameters Of Ivm Following Pourmentioning

confidence: 99%

“…In a few studies available in the literature, the effects of different environmental conditions on the efficacy of endectocides were investigated following pour-on administration in cattle. It has been indicated that IVM and doramectin were efficacious against nematodes in cattle following pour-on administration before or after simulated rain (Rolfe et al, 1997;Rehbein et al, 1999;Skogerboe et al, 1999). Similarly, Gogolewski et al (1997) reported that different climatic conditions such as sunshine, freezing and simulated rain did not affect on the anthelmintic activity of eprinomectin in cattle affected with some nematode species.…”

mentioning

confidence: 99%

The effects of simulated rain and sun exposure on the plasma disposition of ivermectin following pour‐on administration in heifers

Gökbulut

Sekkin

Akşit

et al. 2011

Vet Pharm & Therapeutics

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Efficacy of topical ivermectin following exposure of treated cattle to rain

Cited by 8 publications

References 3 publications

Evaluation of the effect of simulated rainfall on the efficacy of Ivomec Pour-on against Cooperia spp. infection in cattle

Evaluation of the effect of simulated rainfall on the efficacy of Ivomec Pour-on against Cooperia spp. infection in cattle

The effect of Ivermectin pour-on administration against natural Nematodirus spathiger infestations and prevalent rate of that in cattle

The effects of simulated rain and sun exposure on the plasma disposition of ivermectin following pour‐on administration in heifers

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