Efficacy of topical corticosteroid powder for nasal polyps: a double-blind, placebo-controlled study of budesonide

Abstract

Budesonide has been used for a number of years as a topical nasal corticosteroid in the treatment of nasal allergy and nasal polyps. Recently, a new device for powder insufflation where no constituents or preservatives are included has been developed (Rhinocort Turbuhaler, Astra Draco AB, Sweden). The present investigation was designed in order to study the efficacy of topical budesonide powder as the only treatment of nasal polyps. A total of 126 patients entered the study. The medical history and clinical recordings included symptoms and signs, a semiquantitative test of smell and measurement of nasal expiratory peak flow index. Medication was either 200 or 400 micrograms of budesonide powder b.i.d. or placebo. After 1 month an overall assessment of treatment efficacy was made to determine whether the treatment had been a success or a failure. The results showed a statistically significant improvement of symptoms and signs in the actively treated groups. The increase in expiratory peak flow index was about 60% in the actively treated groups as opposed to 16% in the placebo group. The overall assessment of treatment efficacy showed success in about 82% of actively treated patients as opposed to about 43% in the placebo group. It is concluded that budesonide powder is useful in the treatment of nasal polyps.

Difficult asthma

“…Treatment of NP consists of medical and/or surgical treatment. Topical glucocorticosteroid therapy has a well established role in the management of NP, since it has proven efficacy on symptoms and size of polyps and may help prevent the recurrence of NP after surgery (40). Surgical management Difficult asthma of NP aims to restore normal nasal function, including nasal ventilation and sinus drainage, when topical GCS alone are insufficient.…”

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

“…93 To date, however, there have been only a few published studies focusing on INS treatment outcomes in nasal polyposis. Small short-term studies from the 1990s examined the use of aqueous and powder forms of budesonide [97][98][99] and found it to be efficacious in the treatment of small-to largesized polyps. Other studies in patients with severe or bilateral polyposis found evidence of similar efficacy and tolerability of fluticasone propionate or beclomethasone dipropionate, with some evidence that fluticasone had a more rapid onset of action.…”

Effect of Laser Treatment on Olfactory Dysfunction

“…The topic corticosteroid therapy is a well-established part in the treatment of allergic rhinitis [15] and chronic sinusitis [16,17]. Mometasone nasal spray showed the greatest effectiveness in reducing fibroblast cultures in nasal polyps followed by beclomethasone [18].…”