Efficacy of Toltrazuril 5 % Suspension (Baycox®, Bayer) and Diclazuril (Vecoxan®, Janssen-Cilag) in the Control of Eimeria spp. in Lambs

Diaferia, Manuela; Veronesi, Fabrizia; Morganti, Giulia; Nisoli, L.; Fioretti, Daniela Piergili

doi:10.1007/s00436-013-3440-1

Cited by 35 publications

(24 citation statements)

References 12 publications

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“…O aparecimento de oocistos nas fezes dos cabritos com apenas 14 dias de idade indicou que a infecção ocorreu nos primeiros dias de vida, sugerindo infecção por espécies de Eimeria com período pré-patente curto (LIMA, 1981;DAI et al, 2006;RAKHSHANDEHROO et al, 2013;RUIZ et al, 2013). O uso preventivo do toltrazuril no controle da coccidiose tem sido recomendado a partir da 3ª semana de vida ou 10-14 dias após exposição ao ambiente contaminado ou ao primeiro pastejo em bezerros (EPE et al, 2005) e cordeiros (DIAFERIA et al, 2013). Em cabritos, Iqbal et al (2013) ., Salvador, v.16, n.1, p.179-189jan./ (FRANDSEN et al,1992;VIEIRA et al, 2004;LIMA et al, 2009;SILVA et al, 2007;RAKHSHANDEHROO et al, 2013).…”

Section: Resultsunclassified

Uso preventivo do toltrazuril para controle da coccidiose em cabritos de corte criados em região semiárida

Nunes

Cruz

Neto

2015

Rev. bras. saúde prod. anim.

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<p>Objetivou-se com este estudo avaliar a eficácia do toltrazuril no controle da coccidiose em cabritos de corte criados extensivamente em região semiárida e determinar a idade mais adequada para realização do tratamento. Quarenta cabritos foram separados por faixa etária e tratados com toltrazuril em dose única aos 14; 21; 28 e 35 dias de idade. Amostras de fezes foram coletadas semanalmente para determinação do número de oocistos por grama de fezes (Oopg) nas semanas subsequentes ao tratamento. Os animais também foram pesados semanalmente para determinação do ganho de peso médio diário (GPD). Todos os cabritos tratados não apresentaram oocistos nas fezes pelo menos por uma semana após o tratamento. O Oopg dos cabritos tratados, independentemente da idade do tratamento, foi menor do que os não tratados (P<0,05) ao longo de 10 -11 semanas pós-tratamento. O ganho de peso médio diário (GPD) foi similar em todos os tratamentos avaliados. O Oopg não foi influenciado pelo sexo, mas sim pela idade ao tratamento. Os animais tratados aos 21 dias de idade não apresentaram oocistos nas fezes por um período maior que os demais. O tratamento com toltrazuril realizado aos 21 dias de idade foi eficaz para controle da coccidiose em cabritos criados extensivamente no semiárido.</p>

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Section: Resultsunclassified

Uso preventivo do toltrazuril para controle da coccidiose em cabritos de corte criados em região semiárida

Nunes

Cruz

Neto

2015

Rev. bras. saúde prod. anim.

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“…Najskuteczniejszą metodą profilaktyki i zwalczania kokcydiozy w produkcji owczarskiej jest stosowanie chemioterapeutyków (3,5,10,12,16). Ponieważ ich powszechne i rutynowe stosowanie obarczone jest wieloma przeciwwskazaniami oraz ryzykiem rozwoju oporności, dlatego dopuszczenie i sposób użycia kokcydiostatyków szczegółowo regulują krajowe i unijne przepisy prawne.…”

Section: Dynamics Of Lamb Coccidiosis In Indoor Management Systemsunclassified

“…(15), w stadach jagniąt utrzymywanych w systemie alkierzowym siewstwo oocyst wykazuje od 92,7% do 100% osobników. Dane te potwierdzają także inne prace europejskich autorów, w którzy wykazują ponad 90% ekstensywność inwazji u jagniąt w owczarniach (3,4,12). Wysoką ekstensywność eimeriozy od 55% do 100% potwierdziły również badania przeprowadzone w Polsce, co, jak podkreślają autorzy, jest związane z postępującą koncentracją i intensyfikacją hodowli (1,5,10).…”

Section: Wyniki I Omówienieunclassified

“…W przeprowadzonych badaniach na terenie Polski w hodowlach systemu alkierzowego stwierdzono najwyższy poziom oocyst na gram kału w 42. dniu życia jagniąt (5,10). Według innych badań z Europy krytycznym momentem jest natomiast okres przypadający pomiędzy 38. a 50. dniem życia jagniąt, kiedy obserwuje się najwyższe wartości OPG (3,12). W przypadku dużej dynamiki szerzenia się inwazji w stadzie skok liczby OPG do maksymalnych wartości zaobserwować można wcześniej od 21. do 33. dnia po wykotach (15).…”

Section: Wyniki I Omówienieunclassified

“…W przebiegu spontanicznej i nieleczonej kokcydiozy u jagniąt po okresie najwyższej intensywności inwazji następuje spadek wartości OPG, a następnie utrzymywanie się stałej niskiej liczby wydalanych oocyst najczęściej od 150 do 1500 OPG (3,7,15,16). Zależność tę częściowo potwierdziły wyniki własne.…”

Section: Wyniki I Omówienieunclassified

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Dynamics of lamb coccidiosis in indoor management systems

Szczepaniak¹,

Studzińska²,

Jankuszew³

et al. 2018

Medycyna Weterynaryjna

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SummaryInvasions of protozoa belonging to the genus Eimeria are a global problem in sheep farming. The clinical course of eimeriosis occurs almost exclusively in lambs. In adult sheep coccydiosis often has an asymptomatic course which, however, is not without an impact on animal conditions. Large flock density and related contamination of the environment with oocysts is conducive to a high extensiveness of the invasion. The aim of the study was to analyze the prevalence and intensity of Eimeria invasion in lambs kept in confined management systems in order to establish the key periods of the course of invasions and schedules for prevention programs. The parasitological examination was conducted on samples of feces collected directly from the rectum of 96 lambs every 14 days at the following time points: the 28 th , 42 nd , 56 th , 70 th and 100 th days of life. The assessment involved the invasion extensity established using a flotation method and invasion intensity expressed as the number of oocysts per gram of feces (OPG) established by using the McMaster technique. On the basis of morphometric parameters of isolated oocysts, the species of coccidia in the studied animals were determined. During the whole study period, the invasion extensity grew from the minimum of 17.6% (CI ± 95%; 9.6-25.6) on day 28 to the maximum of 95.9% (CI ± 95%; 95.3-100.0) on day 100. The average growth in the invasion extensity in the flock was 19.6% every 14 days. The average invasion intensity in the study period was 3039.2 OPG (min-max 50-58,800; SEM 440.2), with the highest excretion of oocysts observed on day 42 of the lambs' life. The average OPG value on this day was 6783.8, and dropped at subsequent measurement points. The experiment revealed exclusively multi-species invasions. In total, seven species of coccidia were found in the studied animals within the study period. These were: E. bakuensis, E. faurei, E. intricata, E. ovinoidalis, E. pallida, E. parva and E. crandallis.

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Efficacy and economic analysis of two treatment regimens using toltrazuril in lambs naturally infected with Eimeria spp. on pasture

et al. 2017

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This study evaluated the efficacy and the economic viability of two anticoccidial treatment regimens tested in lambs naturally exposed to Eimeria spp. re-infections in a grazing system during a 140-day period. Twenty-four suckling lambs were distributed into three groups based on the individual count of oocysts per gram of feces (OPG) and body weight. Animals were treated with toltrazuril 5% (20 mg/kg) at 14- (GI) or 21-day (GII) intervals, and GIII was kept as untreated control. A cost-benefit analysis of each treatment regimen was calculated. Additionally, economic analysis was performed on four hypothetical scenarios, in which lambs could be having 10, 25, 50, or 85% decrease in their expected body weight gain due to clinical. Efficacy of toltrazuril against Eimeria spp. was 96.9-99.9% (GI) and 74.2-99.9% (GII). E. ovinoidalis was most frequently identified, but no clinical signs of coccidiosis were observed in lambs. There were no differences in weight gain among the groups. The cost of treatment per lamb was $13.09 (GI) and $7.83 (GII). The estimation model showed that the cost-benefit ratio favored treatment with toltrazuril when lambs fail to gain weight. In the studied flock, the break-even point for toltrazuril administered at 14-day intervals was reached with 85% decrease in mean weight gain. In conclusion, toltrazuril can be used at 14-day intervals to control Eimeria spp. (re)-infection in lambs raised on pasture. This treatment regimen was not economically feasible for subclinical coccidiosis; however, it may be feasible when used to prevent weight loss caused by clinical coccidiosis.

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Efficacy of Toltrazuril 5 % Suspension (Baycox®, Bayer) and Diclazuril (Vecoxan®, Janssen-Cilag) in the Control of Eimeria spp. in Lambs

Cited by 35 publications

References 12 publications

Uso preventivo do toltrazuril para controle da coccidiose em cabritos de corte criados em região semiárida

Uso preventivo do toltrazuril para controle da coccidiose em cabritos de corte criados em região semiárida

Dynamics of lamb coccidiosis in indoor management systems

Efficacy and economic analysis of two treatment regimens using toltrazuril in lambs naturally infected with Eimeria spp. on pasture

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