Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat

Benito-de-la-Víbora, Javier; Lascelles, B. Duncan X.; García-Fernández, Paloma; Freire, Milagros; Segura, Ignacio A. Gómez de

doi:10.1111/j.1467-2995.2008.00407.x

Cited by 46 publications

(45 citation statements)

References 34 publications

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“…However, the VAS was not sensitive enough to detect differences in pain levels over time in either treatment group. This result is supported by previous studies that failed to detect significant differences in postoperative pain quantification using the VAS in dogs (Hoelzler and others 2005, Marucio and others 2008) and cats (Tobias and others 2006, Benito-de-la-Víbora and others 2008). In addition, scales that are considered extremely subjective, like the VAS, have shown inconsistent results among different observers when used to assess acute pain in dogs (Holton and others 1998).…”

Section: Discussionsupporting

confidence: 88%

Botulinum toxin type A as an adjunct in postoperative pain management in dogs undergoing radical mastectomy

et al. 2015

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The aim of this randomised placebo-controlled, observer-blinded study was to evaluate the analgesic effects of botulinum toxin type A (BoNT-A) as an adjunct for postoperative pain control in dogs. Sixteen dogs undergoing bilateral radical mastectomy for treatment of mammary tumours were enrolled. Twenty-four hours before surgery, the subjects were distributed into two groups of eight dogs each: 7 iu/kg BoNT-A (BoNT-A) or saline (Control) was administered subcutaneously in each mammary gland. Following sedation with intramuscular 0.03 mg/kg acepromazine and 0.3 mg/kg morphine, anaesthesia was induced intravenously with 4 mg/kg propofol and maintained with isoflurane/O2. Postoperative analgesia was evaluated for 72 hours after extubation using the Visual Analogue Scale (VAS) and modified Glasgow Composite Measure Pain Scale (modified-GCMPS). Rescue analgesia was provided with intramuscular morphine (0.5 mg/kg). Data were analysed using analysis of variance, Tukey's test, Mann-Whitney U test and Friedman test (P<0.05). The pain scores were significantly lower in the BoNT-A than in the Control from 8 hours to 60 hours and from 12 hours to 60 hours after extubation, based on the VAS and modified-GCMPS, respectively. Rescue analgesia was required by significantly more dogs in the Control (7/8) compared with the BoNT-A (2/8) (P=0.022). Pre-emptive BoNT-A appears to be effective as an adjuvant for postoperative pain management in dogs undergoing bilateral radical mastectomy.

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Section: Discussionsupporting

confidence: 88%

Botulinum toxin type A as an adjunct in postoperative pain management in dogs undergoing radical mastectomy

et al. 2015

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“…10 The VAS, SDS, and vFF have been validated and used to assess pain in cats in previous studies. [28][29][30][31][32] Additionally, those scales are easily used to assess postoperative pain in cats in the clinical setting making the current study results relevant to practitioners that perform ovariectomy and ovariohysterectomy.…”

Section: Discussionmentioning

confidence: 99%

“…28,29,31 However, due to the potential adverse effects of nonsteroidal antiinflammatory medications, some veterinarians may be reluctant to use them in routine practice. 35 The study authors did not examine the effect of nonsteroidal anti-inflammatory drugs specifically in this study, and all cats received a single dose of ketoprofen.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Surgical Variables and Pain in Cats Undergoing Ovariohysterectomy, Laparoscopic-Assisted Ovariohysterectomy, and Laparoscopic Ovariectomy

Case

Boscán

Monnet

et al. 2015

Journal of the American Animal Hospital Association

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Laparoscopy is an established modality in veterinary medicine. To date, laparoscopy in feline surgery is rarely reported. The objectives of this study were to compare surgical time, complications, and postoperative pain in a group of cats undergoing laparoscopic ovariectomy (LOVE), laparoscopic-assisted ovariohysterectomy (LAOVH), and ovariohysterectomy via celiotomy (COVH). Eighteen healthy cats were randomly assigned to undergo LOVE, LAOVH, or COVH. Severity of pain was monitored 1, 2, 3, and 4 hr after surgery. Surgical time was significantly longer for LAOVH (mean ± standard deviation [SD], 51.6 ± 7.7 min) compared to COVH (mean ± SD, 21.0 ± 7.1 min) and LOVE (mean ± SD, 34.2 ± 11.2 min). There were no major intraoperative complications, although minor complications were more common in both laparoscopic groups. Cats sterilized via laparoscopy (LOVE and LAOVH) were statistically less painful than cats spayed via celiotomy (COVH) 4 hr following surgery. Results suggested that LOVE in cats is safe, can be performed in a comparable amount of time as COVH, and may result in less postoperative discomfort.

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“…Studies have shown that preoperative administration of tolfenamic acid provides effective analgesia and prevents postoperative pain in dogs (Fonda and Perini 2000;Grandemange et al 2007). In addition, the efficacy of tolfenamic acid and meloxicam in the control of postoperative pain resulting from both orthopaedic surgery and ovariohysterectomy has also been investigated in cats (Benito-de-la-Vibora et al 2008;Murison et al 2010). However, there are no clinical investigations of the relative efficacies of meloxicam and tolfenamic acid in dogs.…”

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confidence: 99%

Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

Hu¹,

Luan²,

Guan³

et al. 2017

Vet. Med. - Czech

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This study was aimed at comparing the postoperative analgesic effects of tolfenamic acid and meloxicam in dogs undergoing ovariohysterectomy. Ovariohysterectomy was performed in 24 female dogs. All dogs were administered pre-anaesthetic medication comprised of 0.02 mg/kg i.m. acepromazine, and general anaesthesia was induced with i.v. propofol (4-6 mg/kg) and maintained with 1.5-2.0% isoflurane. Dogs were divided into three groups (n = 8). Following induction of anaesthesia, group C received 0.05 ml/kg sterile saline i.m.; group T received 4 mg/kg tolfenamic acid i.m.; group M received 0.2 mg/kg meloxicam s.c. Heart rate, respiratory rate, rectal temperature, mean arterial pressure and arterial oxygen saturation of haemoglobin were monitored intraoperatively. Pain was assessed using the short form of the Glasgow composite pain scale (SF-GCPS) by two observers who were blinded to the treatment groups; pain was assessed at the time of pre-medication (baseline), and at 2, 4, 6, 8, 12 and 24 h after extubation. Rescue analgesia (0.2 mg/kg i.m. methadone) was administered to any dog with an SF-GCPS score of greater than or equal to six during postoperative monitoring. The pain score in group C was significantly higher compared with group T and group M at 4, 6 and 8 h, while there were no significant differences between the two treatment groups. The mean pain score in group C was also higher than that in group M at 2 h. Rescue analgesia was first administered at 4 h in group C. Rescue analgesia was required by significantly more dogs in group C (n = 8) compared with groups T (n = 0) and M (n = 1), but there was no significant difference between the two treatment groups. Thus, tolfenamic acid and meloxicam provide adequate postoperative analgesia to similar degrees over 24 h in healthy dogs undergoing ovariohysterectomy.

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Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat

Cited by 46 publications

References 34 publications

Botulinum toxin type A as an adjunct in postoperative pain management in dogs undergoing radical mastectomy

Botulinum toxin type A as an adjunct in postoperative pain management in dogs undergoing radical mastectomy

Comparison of Surgical Variables and Pain in Cats Undergoing Ovariohysterectomy, Laparoscopic-Assisted Ovariohysterectomy, and Laparoscopic Ovariectomy

Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

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