Tolfenamic acid and meloxicam both provide an adequate degree of postoperative analgesia in dogs undergoing ovariohysterectomy

Abstract

This study was aimed at comparing the postoperative analgesic effects of tolfenamic acid and meloxicam in dogs undergoing ovariohysterectomy. Ovariohysterectomy was performed in 24 female dogs. All dogs were administered pre-anaesthetic medication comprised of 0.02 mg/kg i.m. acepromazine, and general anaesthesia was induced with i.v. propofol (4-6 mg/kg) and maintained with 1.5-2.0% isoflurane. Dogs were divided into three groups (n = 8). Following induction of anaesthesia, group C received 0.05 ml/kg sterile saline i.m.; group T received 4 mg/kg tolfenamic acid i.m.; group M received 0.2 mg/kg meloxicam s.c. Heart rate, respiratory rate, rectal temperature, mean arterial pressure and arterial oxygen saturation of haemoglobin were monitored intraoperatively. Pain was assessed using the short form of the Glasgow composite pain scale (SF-GCPS) by two observers who were blinded to the treatment groups; pain was assessed at the time of pre-medication (baseline), and at 2, 4, 6, 8, 12 and 24 h after extubation. Rescue analgesia (0.2 mg/kg i.m. methadone) was administered to any dog with an SF-GCPS score of greater than or equal to six during postoperative monitoring. The pain score in group C was significantly higher compared with group T and group M at 4, 6 and 8 h, while there were no significant differences between the two treatment groups. The mean pain score in group C was also higher than that in group M at 2 h. Rescue analgesia was first administered at 4 h in group C. Rescue analgesia was required by significantly more dogs in group C (n = 8) compared with groups T (n = 0) and M (n = 1), but there was no significant difference between the two treatment groups. Thus, tolfenamic acid and meloxicam provide adequate postoperative analgesia to similar degrees over 24 h in healthy dogs undergoing ovariohysterectomy.

Comparison of Ventral Midline and Right Flank Approaches of Ovariohysterectomy in Bitches

“…All the selected animals have no significant differences in detail (BCS, Age, and Weight). The duration of surgery for OVH in this study was less than those reported by Acharya et al ( 1) that was 49.4 ± 0.59 minutes (VMA) and 26.2 ± 0.76 minutes (RFA), Hu et al (13) was 37.28 ± 5.81 (VMA) min, Sharda et al (22) was 44.25 ± 3.50 (VMA) and 40.50 ± 2.88 (RFA). The variation in the duration of surgery might be due to the age, weight of the animals being operated and experience of the surgeons performing surgery.…”

“…13) that was 23.3 ± 1.9 bpm and 25.3 ± 1.8 bpm respectively but respiration rate after 24 hrs was 27.6 ± 3.2 bpm that was slightly lower. Stretching and severing of ovarian ligament are painful procedures in both methods, significantly increased HR and RR were found during severing of suspensory ligament and cervix in the flank approach.…”

Penanganan Bedah Phimosis pada Anjing

“…Antiinflamasi tolfenamic acid diinjeksi dengan dosis 0,1 ml/kg/bb. Tolfenamic acid adalah obat antiinflamasi non-steroid dari keluarga fenamat dan memiliki sifat anti-inflamasi, analgesik dan antipiretik, pada anjing tolfenamic acid cepat diabsorsi (Hu et al, 2017).…”