Efficacy of surveillance and molecular markers for detection of ulcerative colitis-associated colorectal neoplasia

Fujii, Shigehiko; Fujimori, Takahiro; Chiba, Tsutomu; Terano, Akira

doi:10.1007/s00535-003-1258-9

Cited by 16 publications

(8 citation statements)

References 44 publications

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“…However, according to several studies that have assessed the efficacy of surveillance, an appreciable number of neoplasia were detected at an advanced stage despite surveillance colonoscopy, and many of these cases had less-than-ideal outcomes [6][7][8] . Thus, it still remains questionable whether surveillance colonoscopy with multiple-step biopsy effectively enables early detection of UC-associated neoplasia.…”

Section: Discussionmentioning

confidence: 99%

“…However, because UC-associated neoplasia is often difficult to detect endoscopically and to discriminate from inflammatory regenerative epithelium histologically, it remains a matter of contention whether conventional surveillance colonoscopy is effective for early detection [6][7][8] . In order to improve the efficacy of surveillance, there is an urgent need for sensitive and specific markers to identify individuals at increased risk of neoplasia among patients with long-standing and extensive UC.…”

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confidence: 99%

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Increased Expression of DNA Methyltransferase-1 in Non-Neoplastic Epithelium Helps Predict Colorectal Neoplasia Risk in Ulcerative Colitis

Fujii

Katake²,

Tanaka³

2010

Digestion

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dysplasia and invasive cancer (0.47 8 0.52 vs. 0.58 8 0.63). The expression level of DNMT1 mRNA tended to increase gradually from rectal epithelium of UC patients without neoplasia (0.53 8 0.34) to non-neoplastic rectal epithelium of UC patients with neoplasia (0.88 8 0.57, p = 0.06), and to colorectal neoplasia (1.38 8 0.64, p = 0.07). Conclusion: Increased expression of DNMT1 in non-neoplastic epithelium may precede or be a relatively early event in UC-associated tumorigenesis, and may help predict the risk of colorectal neoplasia in UC.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Increased Expression of DNA Methyltransferase-1 in Non-Neoplastic Epithelium Helps Predict Colorectal Neoplasia Risk in Ulcerative Colitis

Fujii

Katake²,

Tanaka³

2010

Digestion

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“…We also reviewed Japanese case reports of UC-associated neoplasia published between 1990 and 2002 [15]. Of 118 patients with UC-associated neoplasia, 41 underwent surveillance colonoscopy (surveillance group), 64 did not (nonsurveillance group), and the remaining 13 cases were unknown as to surveillance status.…”

Section: Efficacy Of Surveillance For Uc-associated Colorectal Neoplasiamentioning

confidence: 99%

Limits of Diagnosis and Molecular Markers for Early Detection of Ulcerative Colitis-Associated Colorectal Neoplasia

Fujii

Katsumata²,

Fujimori³

2008

Digestion

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The incidence of colorectal neoplasia has been increasing among patients with long-standing and extensive ulcerative colitis (UC), and therefore surveillance colonoscopy has been widely recommended. However, because UC-associated neoplasia is often difficult to detect endoscopically and to discriminate from inflammatory regenerative epithelium histologically, the efficacy of current surveillance remains unsatisfactory. In order to overcome these difficulties, adjunctive modalities for diagnosing UC-associated neoplasia, chromo- and magnifying endoscopy for endoscopic diagnosis and analysis of p53 alteration for histological diagnosis have been introduced. Furthermore, if it were possible to differentiate UC patients with long-standing and extensive colitis into subgroups with a high and a low risk of neoplasia, it would enable physicians to conduct more intensive surveillance with these modalities for patients at higher risk. Several molecular alterations of nonneoplastic epithelium in UC patients with neoplasia may be promising as markers for identifying individuals with UC at increased risk of neoplasia. We evaluated estrogen receptor (ER) methylation of nonneoplastic colorectal epithelium to clarify whether this epigenetic alteration can contribute to the prediction of increased neoplasia risk in UC patients and demonstrated that the ER methylation level in nonneoplastic epithelium was higher throughout the colorectum in patients with neoplasia than in those without. These results suggest that analysis of ER gene methylation may be potentially useful for identifying individuals at increased risk of neoplasia among patients with long-standing and extensive UC.

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“…In Japan, possibly because the number of UC patients with dysplasia/neoplasia is smaller than that in Western countries. We reviewed Japanese case reports of UC-associated dysplasia/neoplasia published between 1990 and 2002 (Fujii et al, 2003b). Of 118 patients with UC-associated neoplasia, 41 underwent surveillance colonoscopy (surveillance group), 64 did not (nonsurveillance group), and the remaining 13 cases were unknown as to surveillance status.…”

Section: Risk Factor and Clinicopathological Characteristics Of Dysplmentioning

confidence: 99%

“…Surveillance (41) Nonsurveillance (64 Fujii et al, 2003b) Regarding depth of tumor invasion, early colorectal cancer, defined as tumor invading the lamina propria and/or muscularis mucosae and/or submucosa, was more frequent in the surveillance group than in the nonsurveillance group (60.5% vs. 27.6%). The incidence of lymph node metastasis was lower in the surveillance group than in the nonsurveillance group (13.8% vs. 52.1%).…”

Section: Risk Factor and Clinicopathological Characteristics Of Dysplmentioning

confidence: 99%

Pathological Issues of Ulcerative Colitis/Dysplasia

Tomita¹,

Fujii²,

Fujimori³

2011

Colonoscopy

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Efficacy of surveillance and molecular markers for detection of ulcerative colitis-associated colorectal neoplasia

Cited by 16 publications

References 44 publications

Increased Expression of DNA Methyltransferase-1 in Non-Neoplastic Epithelium Helps Predict Colorectal Neoplasia Risk in Ulcerative Colitis

Increased Expression of DNA Methyltransferase-1 in Non-Neoplastic Epithelium Helps Predict Colorectal Neoplasia Risk in Ulcerative Colitis

Limits of Diagnosis and Molecular Markers for Early Detection of Ulcerative Colitis-Associated Colorectal Neoplasia

Pathological Issues of Ulcerative Colitis/Dysplasia

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