dysplasia and invasive cancer (0.47 8 0.52 vs. 0.58 8 0.63). The expression level of DNMT1 mRNA tended to increase gradually from rectal epithelium of UC patients without neoplasia (0.53 8 0.34) to non-neoplastic rectal epithelium of UC patients with neoplasia (0.88 8 0.57, p = 0.06), and to colorectal neoplasia (1.38 8 0.64, p = 0.07). Conclusion: Increased expression of DNMT1 in non-neoplastic epithelium may precede or be a relatively early event in UC-associated tumorigenesis, and may help predict the risk of colorectal neoplasia in UC.

The aim of this study was to evaluate the significance of an endoscopic atrophic border and irregular arrangement of collecting venules (IRAC) in the diagnosis of ()-induced gastritis. Upper gastrointestinal tract endoscopy was performed on 723 patients, who were screened them for infection. Any patients who had undergone eradication therapy were excluded from the study. The endoscopic atrophic border and IRAC in each patient were assessed. The status was determined in the patients by combination of a serological test and/or histopathological examination. The infection rates were 95.4% (455/477) in the group with an endoscopic atrophic border and 22.3% (55/246) in the group without an endoscopic atrophic border. In the diagnostic validity check, presence of an endoscopic atrophic border had a sensitivity of 89.2% and a specificity of 89.7%. Furthermore, the infection rates were 95.5% (506/530) in the IRAC group and 2.1% (4/193) in the regular arrangement of collecting venules (RAC) group. In the diagnostic validity check, IRAC had a sensitivity of 99.2% and a specificity of 88.7%. In conclusion, the presence of an endoscopic atrophic border and IRAC are highly indicative of an-infected gastric mucosa.

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