Efficacy of sucralfate for Helicobacter pylori eradication triple therapy in comparison with a lansoprazole‐based regimen

Abstract

Extensive clinical studies of Helicobacter pylori have shown this bacterium to be an important causative factor of peptic ulcer, particularly in its recurrence. Therefore, numerous therapeutic trials for the eradication of H. pylori have been reported. A recent trend in curative therapy has been so-called triple therapy, using a proton pump inhibitor and two different antimicrobials. 1 Sucralfate, which is a widely used cytoprotective agent for the gastric mucosa, is reported to inhibit several of the activities of H. pylori and to enhance the anti-H. pylori activity of antimicrobial agents. 2±11 Therefore, several studies of sucralfate-based eradication therapy have been reported recently. 12±18 However, the ef®cacy and safety of sucralfate-based therapy are still controversial. 19±20 The present study was designed to evaluate the ef®cacy and safety of sucralfate in combination with amoxycillin and clarithromycin as eradication therapy for H. pylori, in comparison with lansoprazole-based triple therapy. PATIENTS AND METHODS PatientsThis study was designed as a prospective, randomized, multicentre study, and was carried out in accordance SUMMARY Background: Sucralfate has an inhibitory action against Helicobacter pylori and enhances the anti-H. pylori activity of antimicrobials. Aim: To evaluate the ef®cacy and safety of sucralfatebased eradication therapy for H. pylori infection, compared with that based on lansoprazole, in a randomized multicentre study. Subjects and methods: The subjects were 150 H. pyloripositive patients. They were randomly assigned to one of two regimens for 2 weeks: sucralfate 1 g t.d.s., amoxycillin 500 mg t.

Comparative evaluation of urine-based and other minimally invasive methods for the diagnosis of Helicobacter pylori infection

“…24,26 Although the diagnostic value of the UBT has been previously reported, [28][29][30][31][32] this test is very expensive and time-consuming. Therefore, the UBT should be used for the confirmation of successful eradication therapy, 8,10,44,48 while it seems not to be adequate for mass surveys for H. pylori infection in large numbers of subjects.…”

“…The urea breath test (UBT) was performed as described previously, 32,43,44 with minor modifications, after overnight fasting. 13 C-Urea (100 mg) dissolved in distilled water was administered.…”

Alternative and rescue treatment regimens for Helicobacter pylori eradication

“…They observed that this regimen achieved an eradication rate of 85%, the same as that obtained with lansoprazole-based triple therapy [76]. In addition, sucralfate, a widely used cytoprotective agent, is also reported to have an eradication rate of 80% when used with amoxycillin and clarithromycin [127].…”

Effects of rebamipide, a gastro‐protective drug on the Helicobacter pylori status and inflammation in the gastric mucosa of patients with gastric ulcer: a randomized double‐blind placebo‐controlled multicentre trial

“…Several clinical trials have produced the results of applying gastro‐protective agents to H. pylori eradication. Documents on sucralfate 18 and ecabet sodium 19 for instance, have reported comparable high eradication rates in combined use of antibiotics with these gastro‐protective drugs instead of proton pump inhibitor. Addition of cetraxate hydrochloride to the triple therapy (with proton pump inhibitor and two antibiotics) has been also reported to improve eradication rate 20 .…”