Efficacy of sublingual misoprostol for induction of labor at term and post term according to parity and membrane integrity: a prospective observational study

Brusati,; Brembilla, Gloria; Cirillo, Federico; Mastricci, Luciana; Rossi, Sandra; Am, Paganelli; Ferrazzi, E.

doi:10.1080/14767058.2016.1179274

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…This allowed us to observe better foetal outcomes than those of the Expedite study while maintaining a non-negligible percentage of NICU admission of 2% and 4 cases of neonatal pH < 7.0 (1%). However, the percentages of admission to NICU as well as the percentages of Caesarean sections were not significantly different from those observed in a large cohort of IOL with 25 mg of sublingual misoprostol (21).…”

Section: Discussioncontrasting

confidence: 73%

Healthy Foetuses. Misoprostol Insert Induction HF MIND. A multicentre Italian study on the misoprostol vaginal insert for induction of labour

et al. 2021

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Objective. To evaluate the efficacy and safety of the misoprostol vaginal insert in a selected cohort of healthy mothers and foetuses at late-term gestation or with premature rupture of membranes. Methods. Retrospective data were collected by 12 centres that previously developed and shared the same protocol for the induction of labour with the misoprostol vaginal insert. Pregnant women at late-term gestation or with premature rupture of membranes with an unfavourable cervix were recruited. To be eligible, maternal and foetal well-being was assessed: absence of medical and/or obstetrical maternal complications, normal foetal growth (abdominal circumference > 10 percentile, AFI > 5 cm, absence of notch in uterine arteries Doppler velocimetry), category I foetal heart rate and, in case of PROM, normal white blood cell count and PCR. Subgroup analyses were performed for parity, status of membranes and BMI < 30 / > 30.

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Section: Discussioncontrasting

confidence: 73%

Healthy Foetuses. Misoprostol Insert Induction HF MIND. A multicentre Italian study on the misoprostol vaginal insert for induction of labour

et al. 2021

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“…Brusati et al 22 evaluated the efficacy of 25 µg of sublingual misoprostol in inducing labor in single births. They found that vaginal birth occurred within 24 hours in 78% of multiparous women and in 65% of nulliparous women.…”

Section: Discussionmentioning

confidence: 99%

Induction of Labor using Misoprostol in a Tertiary Hospital in the Southeast of Brazil

Silva

Júnior

Tahan

et al. 2017

Rev Bras Ginecol Obstet

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Keywords► labor induction ► misoprostol ► oxytocin ► cesarean sections AbstractPurpose To assess cases of labor induction with vaginal 25-µg tablets of misoprostol and maternal outcomes in a tertiary hospital in southeastern Brazil. Methods This was a retrospective cohort study of 412 pregnant women with indication for labor induction. Labor induction was performed with vaginal 25-µg tablets of misoprostol in pregnant women with Bishop scores < 6. Stepwise regression analysis was used to identify the factors present at the beginning of induction that could be used as predictors of successful labor induction. Results A total of 69% of the pregnant women who underwent labor induction progressed to vaginal delivery, and 31% of the women progressed to cesarean section. One or two misoprostol tablets were used in 244 patients (59.2%). Of the 412 patients, 197 (47.8%) required oxytocin later on in the labor process, after induction with misoprostol. The stepwise regression analysis showed that only Bishop scores of 4 and 5 and previous vaginal delivery were independent factors with statistical significance in the prediction of successful vaginal labor induction (β ¼ 0.23, p < 0.001, for a Bishop score of 4 and 5, and β ¼ 0.22, p < 0.001, for previous vaginal delivery). Conclusion Higher Bishop scores and previous vaginal delivery were the best predictors of successful labor induction with vaginal 25-µg tablets of misoprostol. ResumoObjetivo Avaliar os casos de indução do trabalho de parto com misoprostol 25 mcg por via vaginal e seus desfechos maternos em um hospital terciário do Sudeste do Brasil.

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“…Our secondary analysis showed that patients induced for PROM had a better response to the protocol, and even more so if their term at PROM was advanced. Only a few trials have reported data with PROM for IOL with oral misoprostol: “Membrane status brought an additional significant impact on time-to-vaginal delivery as main outcome measure of efficacy” [ 23 ]. Our cohort only included 75 patients with PROM, and thus the power was insufficient to draw certain conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…We know that parity affects time to delivery: “The percentage of vaginal delivery within 24 h is higher in multiparous women than in nulliparous” [ 23 ]. As in the literature, with our multivariable analysis, nulliparity seemed to be a factor indicating poor response to the protocol.…”

Section: Discussionmentioning

confidence: 99%

Factors of Non-Compliance with a Protocol for Oral Administration of Misoprostol (Angusta®) 25 Micrograms to Induce Labor: An Observational Study

Pambet

Delabaere

Figuier

et al. 2023

JCM

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We set out to identify factors of non-compliance with a protocol for the oral administration of misoprostol 25 µg (Angusta®) every 2 h (up to eight tablets), for the induction of labor (IOL). We conducted a retrospective study on IOL at term, on singleton pregnancies from 2019 to 2021, in a university hospital. The study included 195 patients, comprising 144 compliant protocols. Pain was statistically more frequent in the non-compliance group (92.2% vs. 62.5%, p < 0.001), and when a midwife was unavailable (15.7% vs. 0.7%, p < 0.001). A multivariable analysis found factors of good response (defined as going into labor before the administration of the median number of tablets, i.e., six) to be an indication for PROM (OR: 12.03, 95% CI: 5.42–26.71), and gestational age at induction (OR: 1.54, 95% CI: 1.19–2.01), independently of BMI, initial Bishop score, and parity. Patients with pain who were able to follow the protocol delivered 9 h earlier than patients with pain who interrupted the protocol and 16 h earlier than patients who experienced no pain. We identified two key elements that favored compliance: (i) providing the next tablet in advance; and (ii) offering patients early epidural analgesia when in pain in order to continue the protocol and go into labor promptly.

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Efficacy of sublingual misoprostol for induction of labor at term and post term according to parity and membrane integrity: a prospective observational study

Abstract: Sublingually administered misoprostol is an effective and safe method for induction of Labor at term. Parity, status of membranes and BMI significantly affect time to delivery.

Cited by 5 publications

References 25 publications

Healthy Foetuses. Misoprostol Insert Induction HF MIND. A multicentre Italian study on the misoprostol vaginal insert for induction of labour

Healthy Foetuses. Misoprostol Insert Induction HF MIND. A multicentre Italian study on the misoprostol vaginal insert for induction of labour

Induction of Labor using Misoprostol in a Tertiary Hospital in the Southeast of Brazil

Factors of Non-Compliance with a Protocol for Oral Administration of Misoprostol (Angusta®) 25 Micrograms to Induce Labor: An Observational Study

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