Efficacy of Stigmast–5–en–3β–ol Isolated from Salvadora persica L. as Antihyperlipidemic and Anti–tumor agent: Evidence from animal studies

Iyer, Deepa; Patil, U. K.

doi:10.1016/s2222-1808(12)60278-3

Cited by 21 publications

(8 citation statements)

References 8 publications

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“…In a DMBA mutagen model of skin cancer, STIG (0.2-0.4 g/kg PO) resulted in fewer and smaller skin papillomas, which were preceded by significantly longer latency period (Ali et al 2015). STIG (50 mg/kg IP) also slowed tumor cell doubling time in a melanoma xenograft model (Iyer and Patil 2012). Yaccob and colleagues found a striking reduction in an NMU mutagen model of breast cancer, where tumor number was reduced 10-fold suggesting that induced tumors actually regressed in the treatment group (Yaacob et al 2015).…”

Section: Sustaining Proliferative Signalingmentioning

confidence: 98%

Phytosterols and phytostanols and the hallmarks of cancer in model organisms: A systematic review and meta-analysis

Cioccoloni

Soteriou

Websdale

et al. 2020

Critical Reviews in Food Science and Nutrition

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Phytosterols and phytostanols are natural products present in vegetable oils, nuts, and seeds, or added to consumer food products whose intake is inversely associated with incidence and prognosis of several cancers. Randomized cancer prevention trials in humans are unfeasible due to time and cost yet the cellular processes and signaling cascades that underpin anti-cancer effects of these phytochemicals have been explored extensively in vitro and in preclinical in vivo models. Here we have performed an original systematic review, meta-analysis, and qualitative interpretation of literature published up to June 2020. MEDLINE, Scopus, and hand-searching identified 408 unique records that were screened leading to 32 original articles that had investigated the effects of phytosterols or phytostanols on cancer biology in preclinical models. Data was extracted from 22 publications for meta-analysis. Phytosterols were most commonly studied and found to reduce primary and metastatic tumor burden in all cancer sites evaluated. Expression of pAKT, and markers of metastasis (alkaline phosphatase, matrix metalloproteases, epithelial to mesenchymal transcription factors, lung and brain colonization), angiogenesis (vascular endothelial growth factor, CD31), and proliferation (Ki67, proliferating cell nuclear antigen) were consistently reduced by phytosterol treatment in breast and colorectal cancer. Very high dose treatment (equivalent to 0.2-1 g/kg body weight not easily achievable through diet or supplementation in humans) was associated with adverse events including poor gut health and intestinal adenoma development. Phytosterols and phytostanols are already clinically recommended for cardiovascular disease risk reduction, and represent promising anti-cancer agents that could be delivered in clinic and to the general population at low cost, with a well understood safety profile, and now with a robust understanding of mechanism-of-action.

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Section: Sustaining Proliferative Signalingmentioning

confidence: 98%

Phytosterols and phytostanols and the hallmarks of cancer in model organisms: A systematic review and meta-analysis

Cioccoloni

Soteriou

Websdale

et al. 2020

Critical Reviews in Food Science and Nutrition

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“…Therefore, these previous studies suggest the preventive and therapeutic anticancer action of S. persica . Also, stigmast-5,22-dien-3β-ol was purified by ( Iyer and Patil, 2012 ) from the plant and shown to contribute to its antitumor activity. The antioxidant properties of the plant may also help in its antitumor activity.…”

Section: Health Benefits Of the Plant And Its Extractsmentioning

confidence: 99%

Salvadora persica L.: Toothbrush tree with health benefits and industrial applications – An updated evidence-based review

Farag

Abdel‐Mageed

Gamal

et al. 2021

Saudi Pharmaceutical Journal

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Salvadora persica L. is also known as Arak (in Arabic) and Peelu (in Urdu). Its frequent use as a toothbrush (miswak) is highly recommended by Prophet Muhammad. With a long history in folk medicine for centuries, S. persica was used in oral hygiene, food, cosmetics, fuel, and even as a medicine. Previous phytochemical investigation of its different parts afforded different classes of secondary metabolites such as flavonoids, glycosides, sterols, terpenes, carbohydrates and alkaloids. Organic sulfur-containing compounds and elemental sulfur are also present. In addition, there is a huge research on its biological potentials and industrial applications. Many pharmacological activities were reported experimentally, including antimicrobial, antioxidant, analgesic, anthelmintic, anti-inflammatory, antiulcer, sedative, anticonvulsant, anti-osteoporosis, antidiabetic, hypo-lipidemic, in addition to wound-healing, antidepressant and antitumor activities. Recently, a possible activity against COVID-19 protease was documented by molecular docking. This review tries to provide a recent detailed documentation of folk and modern uses of S. persica, focusing on the possible relations between its chemical constituents, pharmacological properties, and industrial applications. Moreover, a brief about recent analytical and validation methods for the major antimicrobial component is reported.

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“…On this investigation, stigmasterol performed about 75% of total apoptosis and induced very low levels of necrosis. This data is quite important since stigmasterol is present in some cytotoxic vegetal species extracts and can satisfactorily contribute to this activity (Ayer, Patil, 2012).…”

Section: Discussionmentioning

confidence: 94%

Passiflora mucronata leaves extracts obtained from different methodologies: a phytochemical study based on cytotoxic and apoptosis activities of triterpenes and phytosterols constituents

Silva

Oliveira

Barbosa

et al. 2020

Braz. J. Pharm. Sci.

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Cancer is one of the most prevalent diseases worldwide and the natural products could be a source of bioactive compounds. Passiflora mucronata (PM) belongs to a very known vegetal genus, although, there are no studies about cytotoxic activity or isolated compounds. Different extracts from PM were obtained by liquid-liquid partition (P), Soxhlet (Sox) and supercritical fluid (SFE1-5) extraction techniques, being compared concerning their yields, chemical profile and cytotoxicity. The Sox extracts showed the highest yields (6.03%: hexane; 2.51%: dichloromethane) followed by SFE (from 4.34 to 1.63%) and partitions (1.06 and 2.26%). The hexane partition (HP) showed the best cytotoxic activity against K562 cell line (IC 50 = 18.72 µg.mL-1). From HP, the following compounds were identified and analysed its cytotoxic activities: β-amyrin (IC 50 = 3.92 µg.mL-1), β-sitosterol (IC 50 = 3.37 µg.mL-1), stigmasterol (IC 50 = 3.31 µg.mL-1) and oleanolic acid. Stigmasterol induced about 75% of K562 total apoptosis. The compounds were tested against MA-104 cell line and the selective index (SI) attributed (SI >10 for all compounds). This indicates good selectivity to K562 cell line at the expense of MA-104. This is the first time, identifying those compounds to PM .

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Efficacy of Stigmast–5–en–3β–ol Isolated from Salvadora persica L. as Antihyperlipidemic and Anti–tumor agent: Evidence from animal studies

Cited by 21 publications

References 8 publications

Phytosterols and phytostanols and the hallmarks of cancer in model organisms: A systematic review and meta-analysis

Phytosterols and phytostanols and the hallmarks of cancer in model organisms: A systematic review and meta-analysis

Salvadora persica L.: Toothbrush tree with health benefits and industrial applications – An updated evidence-based review

Passiflora mucronata leaves extracts obtained from different methodologies: a phytochemical study based on cytotoxic and apoptosis activities of triterpenes and phytosterols constituents

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