Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae)

Molnár, Kálmán; Ostoros, Györgi

doi:10.1556/avet.55.2007.1.7

Cited by 8 publications

(19 citation statements)

References 10 publications

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“…The carbonate 29 and tetrazoles 34 and 35 were inactive against all tested P. falciparum strains. Electron withdrawing substituents appear to have a positive effect on antimalarial activity, though the biphenyl analogue 26 is unusually potent and the dimethylamino (28) and propynoxy (32) compounds also exhibit respectable antiparasitic activity.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Robenidine and other aminoguanidines have been evaluated for efficacy against several other protozoan parasites, including Toxoplasma gondii ( in vitro IC 50 0.03 μg/mL for robenidine), − Leishmania donovani ( in vitro IC 50 18 μM for the analogue CGP 40215A), Babesia microti (murine in vivo nonrecrudescence dose 100 mg/kg/day for oral robenidine), , and the trypanosomes, T. brucei and T. cruzi ( in vitro IC 50 20 μM for the analogue CGP 40215A). − It has also been tested against microorganisms such as Lactobacillus , E. coli , Acanthamoeba polyphaga , Goussia carpelli , and several other Gram-positive and Gram-negative bacterial pathogens. , …”

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confidence: 99%

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Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum

Krollenbrock

Kelly

et al. 2021

ACS Infect. Dis.

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Robenidine is a veterinary drug used in the poultry industry to treat coccidiosis caused by parasites in the Eimeria genus. Though this compound and related aminoguanidines have recently been studied in other pathogens, the chemotype has not been systematically explored to optimize antimalarial activity despite the close genetic relationship between Eimeria and Plasmodium (both are members of the Apicomplexa phylum of unicellular, spore-forming parasites). In this study, a series of aminoguanidine robenidine analogues was prepared and tested in vitro against Plasmodium falciparum , including multidrug-resistant strains. Selected compounds were further evaluated in vivo against murine Plasmodium yoelii in mice. Iterative structure–activity relationship studies led to the discovery of 1 , an aminoguanidine with excellent activity against drug-resistant malaria in vitro and impressive in vivo efficacy with an ED 50 value of 0.25 mg/kg/day in a standard 4-day test.

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Section: ■ Results and Discussionmentioning

confidence: 99%

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confidence: 99%

Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum

Krollenbrock

Kelly

et al. 2021

ACS Infect. Dis.

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“…b Fantham & Porter (1947) L. maculate 1/9 Eimeria sp. d Asmundsson (2003) L. pipiens 1/137 I. lieberküehni c Labbé, (1894); Levine & Nye (1977) L. septentrionalis 7/68 E. algonquini Chen & Desser (1989) 1/68 E. kermiti Chen & Desser (1989) L. sphenocephala 0/15 0 Upton & McAllister (1988) L. sylvaticus 3/9 E. algonquini Chen & Desser (1989) 11/13 E. fitchi McAllister et al (1995) 1/9 E. kermiti Chen & Desser (1989) Pelophylax lessonae Unknown E. prevoti Laveran & Mesnil (1902a); Doflein (1909); Nöller (1913) P. esculenta Unknown I. ranae a Dobell (1909) Unknown E. ranarum Labbé (1894a); Doflein (1909) 7/10 G. neglecta Nöller (1920); Molnár (1995) >6/2,016 H. lieberküehni Nöller (1913Nöller ( , 1923 Grabda-Kazubska (1973, 1974 Isospora sp. b Kazubski & Grabda-Kazubska (1973, 1974 to be continued…”

Section: Ranidaementioning

confidence: 99%

Coccidia (Apicomplexa: Eimeriidae) of amphibians of the world

Duszynski

Bolek

Upton

2007

Zootaxa

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The coccidia are protists (phylum Apicomplexa) that, likely, are both the most abundant (numbers of individual zoites) and most speciose of all the kinds of parasites found in, or on vertebrate animals. They also are among the least studied and understood, with the exception of those species that cause pathology in domesticated hosts. Here we review and evaluate all published descriptions of coccidians within the largest family of the phylum, Eimeriidae Minchin 1903, because there has never been a detailed taxonomic summation for those species that infect amphibians. About 35 of the named species are invalid, either because rules concerning the naming of new species (International Code of Zoological Nomenclature) were not followed and/or the original description was so incomplete as to be of little use; such names have been relegated to species inquirendae, incertae sedis, or nomen nuda. The class Amphibia has three orders, 56 families, 464 genera and 6009 species (Frost et al. 2006). There are no coccidia known from 41 of the 56 (73%) families, 436 of the 464 (94%) genera and 5964 of the 6009 (>99%) species. In the Anura (frogs), only 14 of the 44 (32%) families (Bombinatoridae, Bufonidae, Dicroglossidae, Hylidae, Hyperoliidae, Leptodactyllidae, Limnodynastidae, Megophyridae, Microhylidae, Pipidae, Ptychadenidae, Pyxicephalidae, Ranidae, Rhacophoridae), 30 of the 388 (8.8%) genera, and 67 of the 5283 (1.2%) species have been examined for coccidia and 30 coccidia are known (18 Eimeria, 9 Isospora, 2 Goussia, and 1 Hyaloklossia species). In the Urodela (salamanders), 7 of the 9 (78%) families (Ambystomatidae, Amphiumidae, Cryptobranchidae, Plethodontidae, Proteidae, Salamandridae, Sirenidae), 18 of the 64 (28%) genera and 45 of the 553 (8%) species have been examined and 21 coccidia are known (19 Eimeria and 2 Isospora species). In the Gymnophiona (caecilians), only 1 of 3 (33%) families, 1 of 12 (8%) genera, and only 1 of the 173 (0.6%) species, Dermophis mexicanus (family Caeciliidae), have been examined and 1 Eimeria species is known. Also in the Amphibia, there are 10 species inquirendae (a species of doubtful identity), 22 incertae sedis (uncertain taxonomic position), and 5 names are considered nomen nuda. In general, herpetologists are encouraged to be more receptive to working with parasitologists to use comparative parasite data that might provide insights into amphibian evolution and habitat use. The eimeriid coccidia are ideal parasites for such cooperative efforts because they can be collected easily by noninvasive fecal collections.

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“…pigs [1], cattle [2], sheep [3], rabbits [4] and especially poultry [5, 6]. Also there are known facts of this infection of fish [7, 8]. The disease is caused by several species of unicellular organisms of Eimeria and Isospora protozoa .…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Behavior and Reliable Method for the Determination of Coccidiostat Robenidine in Animal Feed and Poultry Meat

et al. 2020

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The voltammetric behaviour of coccidiostat robenidine was investigated. The outcomes have revealed that reduction of robenidine causes an appearance of one diffusion‐controlled cathodic peak on a static mercury drop electrode (SMDE) and a silver solid amalgam electrode (p‐AgSAE). The influence of pH, a supporting electrolyte, a scan rate and accumulation parameters was evaluated. The mechanism of robenidine reduction involving two electrons and one proton was studied for the first time. The calibration curves with the wide linear concentration ranges (more than two concentration orders) were obtained under optimized experimental conditions and operating parameters. The reduction current linearly increases when increasing the concentration of coccidiostat. The methods of voltammetric determination of robenidine in feed and meat have been developed. The limits of quantitation of the methods of robenidine determination in feed are 9.5 mg/kg and 2.5 mg/kg on SMDE and p‐AgSAE, respectively. Calculated recoveries ranges of robenidine were between 88.8 % and 101.5 %.

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Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae)

Cited by 8 publications

References 10 publications

Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum

Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum

Coccidia (Apicomplexa: Eimeriidae) of amphibians of the world

Voltammetric Behavior and Reliable Method for the Determination of Coccidiostat Robenidine in Animal Feed and Poultry Meat

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