Efficacy of sildenafil as the first-step therapeutic tool for Japanese patients with erectile dysfunction

Ochiai, Atsushi; Naya, Yoshio; Soh, Jintetsu; Ishida, Yuko; Mizutani, Yoichi; Kawauchi, Akihiro; Fujiwara, Terufumi; Miki, Tsuneharu

doi:10.1038/sj.ijir.3901318

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…As far as we know, there has been no previous report on the association between responsiveness to PDE5 inhibitor and MS. Our results show a lower response rate for sildenafil in patients with MS, which was 40%, while previous Japanese reports showed that it was about 70% in general patients [24,25]. Moreover, we revealed that the response rate significantly decreased as the number of MS components increased.…”

Section: Discussioncontrasting

confidence: 61%

Negative Impact of Metabolic Syndrome on the Responsiveness to Sildenafil in Japanese Men

Suetomi

Kawai

Hinotsu

et al. 2008

The Journal of Sexual Medicine

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Introduction Several recent studies suggested that the prevalence of erectile dysfunction (ED) was higher in men with metabolic syndrome (MS). Aim We analyzed the impact of MS on the responsiveness to sildenafil. Methods A total of 133 ED patients were evaluated for the prevalence of MS and graded on severity of ED. MS was diagnosed according to the International Diabetes Federation (IDF) definition. The severity of ED was evaluated by the International Index of Erectile Function (IIEF) questionnaire. Hormonal parameters were measured for all patients, and the IIEF questionnaire was conducted after administration of eight tablets of 50-mg doses of sildenafil. If the scores to questions 3 and 4 of the IIEF were 4 or higher after administration, the patients were defined as responders to sildenafil. Main Outcome Measures To clarify the negative impact of MS on the responsiveness to sildenafil. Results The mean age of the patients was 56.9 years, and 25 patients were diagnosed with MS. The IIEF-erectile function score and the response rate for sildenafil decreased as the number of MS components increased. Logistic regression analysis showed that the presence of MS along with severity of ED and history of pelvic surgery were significant independent risk factors of nonresponse for sildenafil. The hazard ratio for the presence of MS was 3.30 (95% confidence interval [CI]: 1.17–9.73). No meaningful association was observed between total testosterone or free testosterone levels and MS in this population. Conclusion We demonstrated the negative impact of MS on the responsiveness to sildenafil. Erectile function and response rate for sildenafil decreased as the number of MS components increased.

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Section: Discussioncontrasting

confidence: 61%

Negative Impact of Metabolic Syndrome on the Responsiveness to Sildenafil in Japanese Men

Suetomi

Kawai

Hinotsu

et al. 2008

The Journal of Sexual Medicine

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“…10 ED is more prevalent in Japanese men than in American men. However, most elderly men do not complain about dissatisfaction despite declining sexual function.…”

Section: Discussionmentioning

confidence: 95%

Outcome analysis of sildenafil citrate for erectile dysfunction of Japanese patients

et al. 2005

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The approved maximal dose of sildenafil is only 50 mg in Japan, but the impact of dose regulation on treatment outcomes has not been established. Moreover, the contributors to the efficacy in patients having an intact peripheral nervous system have not been fully elucidated. We assessed in Japanese patients the treatment outcomes of sildenafil for erectile dysfunction (ED) under regulation of the approved dose and identified factors contributing to its efficacy among those with various etiologies other than pelvic surgery. We retrospectively reviewed 196 ED patients treated with sildenafil. The overall efficacy was 70.9% (139/196), and patients with psychological problems and concomitant cardiovascular disease showed high response rates (82.4 and 87.0%, respectively). Of the 139 responders, 89.9% achieved efficacy with a dose of 25 or 50 mg. Logistic regression analysis revealed concomitant cardiovascular disease and a favorable nocturnal penile tumescence result to be independent contributors to the efficacy.

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“…In Japan, three PDE5‐I, sildenafil, vardenafil and tadalafil, have been approved and used clinically in recent years. Efficacy among these three drugs as assessed by specific questionnaires, such as the IIEF and the SEP has been reported to be similar in Japanese patients with ED . Although the IIEF has contributed to research and clinical practice in the area of ED including the assessment of PDE5‐I, the questionnaire provides limited assessment of erection quality beyond the ability to achieve or maintain an erection sufficient for penetration.…”

Section: Introductionmentioning

confidence: 99%

“…Efficacy among these three drugs as assessed by specific questionnaires, such as the IIEF 2 and the SEP has been reported to be similar in Japanese patients with ED. [3][4][5] Although the IIEF has contributed to research and clinical practice in the area of ED including the assessment of PDE5-I, the questionnaire provides limited assessment of erection quality beyond the ability to achieve or maintain an erection sufficient for penetration. The SEP also focuses on the success rate of penetration and maintenance of erection.…”

Section: Introductionmentioning

confidence: 99%

Sexual life of Japanese patients with erectile dysfunction taking phosphodiesterase type 5 inhibitors: An Internet survey using the Psychological and Interpersonal Relationship Scales‐Short Form questionnaire

et al. 2014

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Objectives: To investigate details of sexual function of erectile dysfunction in Japanese patients taking phosphodiesterase type 5 inhibitors. Methods: A Japanese version of the Psychological and Interpersonal Relationship ScalesShort Form was used to carry out a nationwide survey using the Internet. A total of 556 erectile dysfunction patients (age 30-70 years) who had been prescribed a phosphodiesterase type 5 inhibitor and had attempted sexual intercourse within the past 6 months were included in this survey. Scores were compared in relation to the phosphodiesterase type 5 inhibitors most frequently taken within the past 6 months. Results: In the subdomains of self-confidence and spontaneity of the Psychological and Interpersonal Relationship Scales-Short Form, scores for vardenafil and tadalafil were significantly higher than those for sildenafil. In the subdomain of time concern of the Psychological and Interpersonal Relationship Scales-Short Form, the score for tadalafil was significantly lower than that for others. Conclusions: Our findings support the hypothesis that Japanese patients with erectile dysfunction have high sexual self-confidence, spontaneity and low time concerns when taking tadalafil. These characteristics of tadalafil could be associated with high patient satisfaction and high preference.

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Efficacy of sildenafil as the first-step therapeutic tool for Japanese patients with erectile dysfunction

Cited by 5 publications

References 13 publications

Negative Impact of Metabolic Syndrome on the Responsiveness to Sildenafil in Japanese Men

Negative Impact of Metabolic Syndrome on the Responsiveness to Sildenafil in Japanese Men

Outcome analysis of sildenafil citrate for erectile dysfunction of Japanese patients

Sexual life of Japanese patients with erectile dysfunction taking phosphodiesterase type 5 inhibitors: An Internet survey using the Psychological and Interpersonal Relationship Scales‐Short Form questionnaire

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