Efficacy of selected oral chemotherapeutants against Ichthyophthirius multifiliis (Ciliophora: Ophyroglenidae) infecting rainbow trout Oncorhynchus mykiss

Shinn, Andrew P.; Wootten, R.; Côté, Isabelle; Sommerville, Christina

doi:10.3354/dao055017

Cited by 25 publications

(13 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Shinn et al (2003b) demonstrated that the two anti-coccidiostats compounds, amprolium hydrochloride and salinomycin sodium, when incorporated into a commercial feed, were able to significantly reduce the number of trophonts establishing on fish. Treatment with 100 mg l − 1 of amprolium hydrochloride (a thiamine, vitamin B1, analogue) for 1 h compromised the survival of the tomocyst stage in vitro, ultimately killing 85-90% of the tomocysts (Shinn et al 2001).…”

Section: In-feed Treatmentsmentioning

confidence: 99%

An assessment of the use of drug and non-drug interventions in the treatment ofIchthyophthirius multifiliisFouquet, 1876, a protozoan parasite of freshwater fish

et al. 2011

View full text Add to dashboard Cite

Infection by the ciliate protozoan Ichthyophthirius multifiliis Fouquet, 1876 causes significant economic losses in freshwater aquaculture worldwide. Following the ban on the use of malachite green for treating food fish, there has been extensive research aimed at identifying suitable replacements. In this paper we critically assess drug and non-drug interventions, which have been tested for use or have been employed against this parasite and evaluate possibilities for their application in farm systems. Current treatments include the administration of formaldehyde, sodium chloride (salt), copper sulphate and potassium permanganate. However, purportedly more environmentally friendly drugs such as humic acid, potassium ferrate (VI), bronopol and the peracetic acid-based products have recently been tested and represent promising alternatives. Further investigation, is required to optimize the treatments and to establish precise protocols in order to minimize the quantity of drug employed whilst ensuring the most efficacious performance. At the same time, there needs to be a greater emphasis placed on the non-drug aspects of management strategies, including the use of non-chemical interventions focusing on the removal of free-swimming stages and tomocysts of I. multifiliis from farm culture systems. Use of such strategies provides the hope of more environmentally friendly alternatives for the control of I. multifiliis infections.

show abstract

Section: In-feed Treatmentsmentioning

confidence: 99%

An assessment of the use of drug and non-drug interventions in the treatment ofIchthyophthirius multifiliisFouquet, 1876, a protozoan parasite of freshwater fish

et al. 2011

View full text Add to dashboard Cite

show abstract

“…However, treatment of ichthyophthiriasis via bath application is difficult because the therapeutant eliminates neither the trophonts located in the epidermis of the fish nor the encysted tomonts, both of which are less susceptible to chemical treatment than the theronts (Mei nelt et al 2009). Therefore, a medicated feed would be beneficial for treating this disease because it would directly affect the stages on the host, be easier to administrate in aquaculture situations and cause less environmental contamination (Luzardo-Álvarez et al 2003, Shinn et al 2003. To date, various substances have been tested for their suitability as in-feed treatments.…”

Section: Introductionmentioning

confidence: 99%

“…A reduction in the degree of the infection could also be achieved with triclabendazole in an inclusion complex with β-cyclodextrin (LuzardoÁlvarez et al 2003). In the study of Shinn et al (2003) the oral application of amprolium hydrochloride and clopidol led to a significant reduction of trophont numbers.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of quinine against ichthyophthiriasis in common carp Cyprinus carpio

Schumacher¹,

Wedekind²,

El-Matbouli³

2011

Dis. Aquat. Org.

View full text Add to dashboard Cite

Ichthyophthiriasis, caused by Ichthyophthirius multifiliis, is an economically important worldwide parasitic disease that infects all freshwater fish. Since the banning of malachite green for use in food fish, there has been a great need for alternative therapeutants. The goal of this study was to investigate the efficacy of quinine against I. multifiliis. Parasite developmental stages from our laboratory-established life cycle in rainbow trout Oncorhynchus mykiss were exposed to quinine in vitro, and a dual fluorescent staining technique was used to allow a clear distinction between viable and damaged parasites. Furthermore, the effect of quinine was assessed in vivo by oral administration and intraperitoneal injections in common carp Cyprinus carpio. The results of the in vitro experiments proved quinine to be effective against the parasite. Quinine injected at a dosage of 60 mg kg -1 body weight resulted in a significantly lower number of trophonts. In contrast, in-feed trials did not show a significant reduction of trophonts after treatment commencing 1 d after infection with concentrations of up to 20 g quinine kg -1 feed for 3 d. After a 14-d treatment at concentrations of up to 10 g quinine kg -1 feed prior to theront exposure, there was also no significant difference in parasite numbers between treated and control groups. The results of oral versus parenteral application of quinine indicate that the substance is not completely absorbed from the intestinal tract of common carp. However, medicated feed containing higher concentrations of quinine was less readily accepted by the fish, presumably due to the bitter taste.

show abstract

“…The medicated food contained some of the anticoccidial drugs (amprolium, salinomycin Na, monensin Na, toltrazuril) in doses recommended against diseases caused by other fish-parasitic protozoans (Ichthyophthirius, Hexamita) or myxozoans (Myxobolus) Santamarina, 1998, 2001;Shinn et al, 2003;Athanassopoulou et al, 2004). For the sake of standardisation we used similar doses of the other tested drugs as well, which meant that in the case of diclazuril, maduramicin and robenidine significantly larger amounts of drugs were mixed in the food than recommended by the manufacturers for treating chicken coccidiosis (see Table 1).…”

Section: Methodsmentioning

confidence: 99%

Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae)

Molnár

Ostoros

2007

Acta Veterinaria Hungarica

View full text Add to dashboard Cite

In this study, nine anticoccidial drugs commonly used in poultry were tested for efficacy for the prevention and treatment of Goussia carpelli (Apicomplexa) infection in common carp (Cyprinus carpio L.). To establish experimental infection with G. carpelli, paratenic host oligochaetes of the genera Tubifex and Limnodrilus were infected with oocysts, and laboratory-cultured parasite-free common carp fingerlings were infected by feeding to them oligochaetes containing sporozoites. The anticoccidial drugs (amprolium, narasin, maduramicin, salinomycin Na, lasalocid Na, diclazuril, robenidine HCl, monensin Na and toltrazuril), mixed in the food of the fish in a dose of 200 mg/kg, were fed for 12 days. Common carp fingerlings fed diclazuril, lasalocid, robenidine HCl or maduramicin and killed on day 14 after exposure were free from infection, while other groups treated with amprolium, toltrazuril, monensin Na, narasin or salinomycin Na harboured oocysts in the mucus and epithelium of the gut.

show abstract

Efficacy of selected oral chemotherapeutants against Ichthyophthirius multifiliis (Ciliophora: Ophyroglenidae) infecting rainbow trout Oncorhynchus mykiss

Cited by 25 publications

References 17 publications

An assessment of the use of drug and non-drug interventions in the treatment ofIchthyophthirius multifiliisFouquet, 1876, a protozoan parasite of freshwater fish

An assessment of the use of drug and non-drug interventions in the treatment ofIchthyophthirius multifiliisFouquet, 1876, a protozoan parasite of freshwater fish

Efficacy of quinine against ichthyophthiriasis in common carp Cyprinus carpio

Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae)

Contact Info

Product

Resources

About