Efficacy of Rhus coriaria (sumac) juice in reducing muscle pain during aerobic exercise

Ah, Alghadir; Gabr, Sami A.

doi:10.1556/036.103.2016.2.10

Cited by 10 publications

(16 citation statements)

References 53 publications

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“…Alghadir et al investigated the effects of sumac juice after acute, intense exercise for 30 days and showed reduced muscle indices and pain in the treatment group. The protective activity on muscle was discussed as being related to the antioxidant activity of phenolic components in sumac juice (Alghadir & Gabr, ). The most important goal in NEC treatment is to reduce oxidant stress (Cakir et al, ; Lim et al, ; Tayman et al, ).…”

Section: Discussionmentioning

confidence: 99%

Sumac ( Rhus coriaria ) for the prevention and treatment of necrotizing enterocolitis

et al. 2019

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Leukotrienes, free oxygen radicals, tumor necrosis factor-alpha, and inflammatory mediators play major roles in the development of necrotizing enterocolitis (NEC). Rhus coriaria (RC: sumac) extracts may enhance cell viability by reinforcing defensesagainst free radical species in several progressive diseases as well as inflammatory diseases. The aim of the present study was to evaluate the effects of RC in a rat NEC model in terms of intestinal damage. Newborn pups were separated into three groups: control, NEC, and NEC treated with RC. Mortality and clinical sickness scores were evaluated. At the end of the study, ileum and proximal colon were obtained from all rats and histopathological and immunohistochemical studies were performed. In this study, the anti-inflammatory, antioxidant, immunomodulatory, and anti-apoptotic activities of RC were demonstrated in a rat NEC model, which suggests RC as a promising treatment option for preventing intestinal tissue damage. Practical applicationsFree oxygen radicals, tumor necrosis factor-alpha, and inflammatory mediators play major roles in the development of NEC. Intestinal tissue damage is caused by necrosis and apoptosis as a result of intestinal inflammation and release of pro-inflammatory cytokines. Anti-inflammatory, antioxidant, immunomodulatory, and anti-apoptotic activities of RC are especially due to its phenolic compounds. In this study, the antiinflammatory, antioxidant, immunomodulatory, and anti-apoptotic activities of RC were demonstrated in a rat NEC model. RC can suggest as a new treatment option for preventing intestinal injury. K E Y W O R D Santi-

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Section: Discussionmentioning

confidence: 99%

Sumac ( Rhus coriaria ) for the prevention and treatment of necrotizing enterocolitis

et al. 2019

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“…), a flowering plant that grows in temperate and tropical regions, contains over 250 individual species worldwide [15]. It is usually used as spice and a medicinal herb in most of the world, particularly for its antiviral [16,17], antimicrobial, antibacterial, antioxidant, and wound-healing [18][19][20][21][22][23][24][25][26] properties. e antiviral activity of Rhus spp., particularly Rhus chinensis, has been explored in many studies.…”

Section: Introduction E Coronavirus Disease 2019 (Covid-19) Crisis Stmentioning

confidence: 99%

“…e review study demonstrated that sumac could be useful in COVID-19 infection due to its versatile activities as anti-inflammatory, antimicrobial, antioxidant, and antimalarial effects [48]. In addition, the review article along with others mentioned that use of sumac as syrup or in capsules with different concentrations has no toxicity on human life and could be recommended in treatment protocol for COVID-19 patients [18,[48][49][50][51].…”

Section: Introduction E Coronavirus Disease 2019 (Covid-19) Crisis Stmentioning

confidence: 99%

“…Regarding previous molecular docking studies [12,18,36,[44][45][46][47][48][49][50][51][52], we are trying to explore the potential inhibitory effects of some Rhus spp. (sumac) constituents against the SARS-CoV-2 main protease enzyme using molecular docking, drug likeness, and synthetic accessibility score analysis.…”

Section: Introduction E Coronavirus Disease 2019 (Covid-19) Crisis Stmentioning

confidence: 99%

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Phytochemicals of Rhus spp. as Potential Inhibitors of the SARS-CoV-2 Main Protease: Molecular Docking and Drug-Likeness Study

Sherif

Gabr

Hosny

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. The outbreak of coronavirus disease 2019 (COVID-19) induced by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in China and spread to cover the entire world with an ongoing pandemic. The magnitude of the situation and the fast spread of the new and deadly virus, as well as the lack of specific treatment, led to a focus on research to discover new therapeutic agents. Aim. In this study, we explore the potential inhibitory effects of some active polyphenolic constituents of Rhus spp. (sumac) against the SARS-CoV-2 main protease enzyme (Mpro; 6LU7). Methods. 26 active polyphenolic compounds of Rhus spp. were studied for their antiviral activity by molecular docking, drug likeness, and synthetic accessibility score (SAS) as inhibitors against the SARS-CoV-2 Mpro. Results. The results show that all tested compounds of sumac provided good interaction with the main active site of SARS-CoV-2 Mpro, with better, lower molecular docking energy (kcal/mol) compared to the well-known drugs chloroquine and favipiravir (Avigan). Only six active polyphenolic compounds of Rhus spp. (sumac), methyl 3,4,5-trihydroxybenzoate, (Z)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-hydroxyprop-2-en-1-one, (Z)-2-(3,4-dihydroxybenzylidene)-6-hydroxybenzofuran-3(2H)-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chroman-4-one, 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-chroman-4-one, and 3,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, were proposed by drug likeness, solubility in water, and SAS analysis as potential inhibitors of Mpro that may be used for the treatment of COVID-19. Conclusion. Six phenolic compounds of Rhus spp. are proposed for synthesis as potential inhibitors against Mpro and have potential for the treatment of COVID-19. These results encourage further in vitro and in vivo investigations of the proposed ligands and research on the preventive use of Rhus spp. against SARS-CoV-2.

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“…Rhus coriaria consists of compounds such as tannins, phenolic acids, flavonoids, terpenoids, and essential oil composed of monoterpenes that have numerous biological activities, which are used as hair cleaning solutions or anti-dandruff agents for the improvement of dermatological problems [16,17]. It has antimicrobial, antiviral, antifungal, antioxidant, anti-inflammatory, and anticancer activities [18,19]; it is also used orally for reducing blood glucose, uric acid, and cholesterol levels [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Efficacy of Sumac Topical Solution Against Permethrin-resistant Human Head Lice

Kamalinejad

Sharif

Gachkar

et al. 2019

IJMTFM

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The present study aimed at determining the efficacy of applying Rhus coriaria (Sumac) solution for the treatment of Permethrin-resistant head louse in patients, who used permethrin for at least 2 consecutive periods, but have not been cured. Methods: This study is a before-after clinical trial performed on 100 patients with pediculosis aged between 2 and 50 years old and both sexes. All patients had used Permethrin at least twice consecutively (with at least 14 days interval) according to correct instructions (on the first and 7 th day), but they have not been cured. Each patient received 60ml of Rhus coriaria solution for 3 consecutive days, and the treatment was repeated again for another 3 days; then, the patients were followed-up on the 4 th , 10 th , and14 th days after the treatment. Results: The results showed a significant difference in the severity of head lice infection and itching before the treatment and 14 days after the treatment (P<0.001). Conclusion: Rhus coriaria solution was more effective in eliminating head-louse infestations on 4, 10, and 14 days after the treatment and itching disappeared in most of the patients, while negligible complications were observed.

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Efficacy of Rhus coriaria (sumac) juice in reducing muscle pain during aerobic exercise

Cited by 10 publications

References 53 publications

Sumac ( Rhus coriaria ) for the prevention and treatment of necrotizing enterocolitis

Sumac ( Rhus coriaria ) for the prevention and treatment of necrotizing enterocolitis

Phytochemicals of Rhus spp. as Potential Inhibitors of the SARS-CoV-2 Main Protease: Molecular Docking and Drug-Likeness Study

Investigating the Efficacy of Sumac Topical Solution Against Permethrin-resistant Human Head Lice

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