Efficacy of pyrantel pamoate against a macrocyclic lactone-resistant isolate of Parascaris equorum in horses

Reinemeyer, Craig R.; Prado, Julio César Acosta; Nichols, Eric C.; Marchiondo, Alan A.

doi:10.1016/j.vetpar.2010.02.041

Cited by 26 publications

(23 citation statements)

References 12 publications

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“…Studies carried out in recent years have indicated that these compounds may also cause oxidative stress in a host (Pinlaor et al 2008, Dewa et al 2009). The majority of publications on pyrantel mainly focus on the efficacy of its therapeutic activity (Slocombe et al 2007, Reinemeyer et al 2010, and the data on its effect on the antioxidant status include only previous publications of authors Zasadowski 2006, Barski andSpodniewska 2012). In the present study, the exposure of rats to pyrantel embonate at a dose of 1/5 LD 50 for three consecutive days caused only a slight decrease in GSH level and an increase in the activity of GPx and GR in comparison with the control group.…”

Section: Discussionmentioning

confidence: 47%

Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel

Spodniewska¹,

Barski²,

Ziółkowski³

2014

Polish Journal of Veterinary Sciences

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The study was undertaken to examine the effect of single and combined administration of dimethoate (an OP insecticide) and pyrantel embonate (an anthelmintic agent) on the concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx) and glutathione reductase (GR) in rats. Dimethoate (Group I) was administered to rats at a dose of 1/10 LD 50 for 5 consecutive days and pyrantel embonate (Group II) at a dose of 1/5 LD 50 for 3 consecutive days. The animals of group III were given both of the mentioned above compounds in the same manner as group I and II, but pyrantel embonate was applied on day 3, 4, and 5 from the beginning of dimethoate intoxication. Material from 6 rats randomly selected from each group was obtained after 3, 6 and 12 hours and 2, 7 and 14 days following the last applied dose of the compounds under study. It was found that application of pyrantel embonate caused only slight changes in the analysed parameters i.e. GSH, GPx and GR. Dimethoate administration caused disturbances in the antioxidative system manifested as a decrease in GSH concentration in the liver (max. -37.7% after 6 hours) and an increase of GPx and GR activities in erythrocytes (max. -21.7% and 29.6% after 3 hours, respectively), compared to the control group. The profile of changes after combined intoxication was similar, but their intensity was higher compared to the group of animals exposed to dimethoate only. Based on current studies, it was concluded that both dimethoate and pyrantel embonate at the applied doses showed a pro-oxidative activity.

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Section: Discussionmentioning

confidence: 47%

Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel

Spodniewska¹,

Barski²,

Ziółkowski³

2014

Polish Journal of Veterinary Sciences

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“…The efficacy of pyrantel products is often described in the context of their use against ivermectin-resistant ascarid populations. Such studies were conducted in the USA and Europe and all of them confirmed a good effect of tetrahydropyrimidines on resistant ascarid populations (Slocombe et al 2007;von Samson-Himmelstjerna et al 2007;Reinemeyer 2009;Reinemeyer et al 2010).…”

Section: Discussionmentioning

confidence: 79%

“…This solution is not realistic, though, because exposure of foals occurs gradually, the foals are simultaneously infected by various developmental stages of the parasites and younger, less susceptible developmental stages can survive the therapy (Reinemeyer 2012). Some authors recommend starting anthelmintic therapy around 60-70 days after birth on farms where ascarid infection in foals poses a problem in order to reduce the pasture contamination (Reinemeyer et al 2010).…”

Section: Discussionmentioning

confidence: 99%

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Monitoring the avermectin and pyrantel resistance status of nematode parasites of horses in the Czech Republic

Bodeček¹,

Svetlikova²,

Hargitaiova³

et al. 2018

Vet. Med. - Czech

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ABSTRACT:The avermectin and pyrantel resistance of equine parasites was monitored on four farms in the Czech Republic in 2014. The aim of the testing was to investigate the anthelmintic resistance of cyathostomins and ascarids. One hundred and eighty-six horses were included in the test, 54 of which were infected by ascarids and 174 by cyathostomins. Faecal egg count reduction tests were used to assess anthelmintic resistance. The faecal egg count reduction for ascarids was within the range of 87.9% to 100% for avermectins and 100% for pyrantel embonate. Faecal egg count reduction for cyathostomins ranged from 99% to 100% for avermectins and 89.3% to 98.2% for pyrantel embonate.

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“…Resistance clearly involves the entire macrocyclic lactone class because sequential dosing of individual foals with ivermectin and moxidectin failed to reduce egg counts after either treatment (Reinemeyer et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Cinnamomum zeylanicum, Punica granatum Flower and Capsicum annuum Extracts Against Parascaris equorum Infective Larvae

Rakhshandehroo¹,

Asadpour²,

Jafari³

et al. 2016

İstanbul Üniv. Vet. Fak. Derg.

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Recent investigations have shown that plants with medicinal peculiarities as good alternative to anthelmintics for livestock. In this study, the anthelmintic effects of three medicinal herbs (Cinnamomum zeylanicum, Punica granatum flower and Capsicum annuum) were screened in vitro against the infective larvae of Parascaris equorum. The recovered larvae of the parasite were exposed to four concentrations (50, 75, 100 and 125 mg/mL) of the extracts and then they examined for the viability at 0, 10, 20, 30 and 40 minutes after the challenge. The results revealed that all the concentrations of each plant extract had anthelmintic effects on P. equorum larvae. Also, the statistics indicated that there were significant interactions between the concentration of the extracts and time of exposure on the number of viable larvae. In addition, C. annuum extract seemed to be a strong potency to kill larvae at all concentrations from the beginning of the experiment. These results confirmed that those herbal extracts possess good antiparasitic effects against infective larvae of P. equorum and thus could be considered in anthelminthic treatment strategies.

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Efficacy of pyrantel pamoate against a macrocyclic lactone-resistant isolate of Parascaris equorum in horses

Cited by 26 publications

References 12 publications

Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel

Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel

Monitoring the avermectin and pyrantel resistance status of nematode parasites of horses in the Czech Republic

The Effectiveness of Cinnamomum zeylanicum, Punica granatum Flower and Capsicum annuum Extracts Against Parascaris equorum Infective Larvae

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