Efficacy Of Pulse Therapy Of Oral Fluconazole In The Treatment Of Seborrheic Dermatitis

Abstract

Abstract:An interventional study was carried out for a period of total two years in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Total sixty five patients of seborrheic dermatitis were selected and were treated with oral fluconazole 150mg in a single dose per week for 4 weeks. Follow up were done at the end of 4 th week and 8 th week. Among the patients, 31-45 years age group was highest 44%, highest 54% males and 21(32%) had positive family history of seborrheic dermatitis. Regarding site of lesions, maximum patients of seborrheic dermatitis 92% had involvement of scalp; next 46% had involvement in the eyebrow. The study showed that the response was very good in 31.5 of cases, good response was found in 24.5% of cases, fair in 26% of cases and poor response was observed in 18.5% of cases. The study showed that 83% of study population was seen without clinical side-effect and only 17% were seen with side-effect(anorexia and dydpepsia) and it was showed that very good improvement 35% observed on the 1 st follow up visit at the fourth week, 30% had good, 15% fair and poor improvement 20% respectively. On the 2 nd follow up visit at the end of eight week, very good improvement was 39% cases; good, fair and poor improvement was 26%, 20% and 17% respectively. The results of this study indicate that fluconazole provides benefit for the therapy of seborrheic dermatitis. However, larger studies using different dosages and durations of therapy, fluconazole may provide a rationale for systemic use of fluconazole in seborrheic dermatitis.

Development, Characterization, andIn VitroBiological Performance of Fluconazole-Loaded Microemulsions for the Topical Treatment of Cutaneous Leishmaniasis

“…Hence, the searching for alternatives to conventional treatment for CL has been shown to be extremely valuable. One of these alternatives is administration of imidazole antifungals such as fluconazole (FLU), also known as [2-(2,4-difluorophenyl)-1,3-bis (1H-1,2,4-triazol-1-yl) propan-2-ol], that presents moderate lipophilicity (log 0.5), renal excretion of over 80% of the unchanged drug, a half-life of 30 hours, 12% binding plasma protein, and over 90% bioavailability when orally administered [ 7 – 11 ].…”