Efficacy of prostaglandin F 2α and misoprostol in the induction of parturition in goats

Pregnant goats were induced to parturition on day 145 of pregnancy, with three different protocols: group Cl (n = 19) was injected intramuscularly (IM) with 75 microg of the prostaglandin analogue R-Cloprostenol; group L (n = 20) was treated IM with 7.5 mg of the prostaglandin analogue Luprostiol; group L(50) (n = 18) was injected IM with 3.75 mg of Luprostiol (IM); in addition, Group S (Control, n = 15) was injected IM with 1 ml of saline solution. Thereafter, goats were continuously observed to record the following parameters: parturition, dystocia incidence, placental delivery and kid and maternal survival. Moreover, blood sampling was performed around kidding and plasma progesterone concentrations were analyzed. The interval from injection to parturition (mean +/- SEM) was not significantly different among the experimental groups: 35.1 +/- 1.5 h, 33.3 +/- 0.9 h and 34.1 +/- 1.8 h (groups Cl, L and L(50), respectively). In the control group, time to parturition was 99.4 +/- 12.1 h (range: 34-166 h). All the goats expelled the foetal membranes within the first 2 h after the induction. The incidence of dystocia due to foetal posture was not significantly different between induced and control goats (21.1%, 20.0%, 22.0% and 20%, for groups Cl, L, L(50) and S, respectively). The percentage of live kids was practically similar between induced goats (93.9%, 94.9% and 92.1%, for groups Cl, L and L(50), respectively); in addition, there was a case of maternal mortality in control group (6.7%; 1/15), whereas there was no mortality in induced goats (0%; 0/57). Plasma concentrations of progesterone showed an intense drop (<2 ng/ml) at 24 h after induction. This study confirms the effectiveness of the luprostiol to induce the parturition in goats, within a narrow range (30-40 h) in most of the induced females (80.0%, 7.5 mg; 77.8%, 3.75 mg).

Section: Introductionmentioning

confidence: 99%

Use of Luprostiol and Cloprostenol for Induction of Parturition in Pregnant Goats

Batista

Niño

Alamo

et al. 2009

“…After the luprostiol injection, a fast decrease in the plasmatic progesterone concentration was observed, reaching basal levels (<1 ng/ml) at the parturition time. Different studies have related similar findings after the administration of natural PGF 2∞ (Bretzlaff and Ott 1983; Alan and Tasal 2002) or prostaglandin analogues (Batista et al. 2009).…”

Section: Discussionmentioning

confidence: 71%

“…2001; Alan and Tasal 2002) or prostaglandin analogues (Walker 1983; Haibel and Hull 1988; Alan and Tasal 2002), where the time to parturition ranged between 31 and 35 h. However, when the goats were administered with the lower dose of aglepristone (1.5 mg/kg), the interval from injection to parturition was notably higher than in other induced goats: the kidding was spread over a longer period of time and was not as predictable. Different studies have confirmed that the interval to parturition can be modified depending on the drug dose (Bretzlatt and Ott 1983; Alan and Tasal 2002); the time from injection to kidding was longer when goats were injected with low doses (2.5 mg) of natural PGF 2∞ compared to the time to parturition after the administration of 10–20 mg PGF 2∞ . For the control goats, the distribution of kidding showed a wide range, and spontaneous parturition was more difficult to accurately predict.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Induction of Parturition with Aglepristone in the Majorera Goat

Batista

Reyes

Santana

et al. 2011

This study assessed the efficacy of aglepristone at inducing parturition in pregnant goats. Six experimental groups were defined: group A-5 (n = 12), group A-3.3 (n = 12), group A-2.5 (n = 12) and group A-1.5 (n = 12) in which goats were injected SC once with 5.0, 3.3, 2.5 and 1.5 mg of aglepristone per kg body weight of goat, respectively, group L (n = 11), which was treated IM with 3.75 mg of luprostiol; and group Ct (n = 11), which was injected SC with 1 ml of saline solution. Different parameters associated with parturition were thereafter investigated. In addition, plasma progesterone concentrations were defined after treatments till parturition. Aglepristone effectively induced parturition in all of the goats. In the A-5, A-3.3 and A-2.5 groups, the time to parturition was around 30-34 h, and the majority of goats (97.2%, 35/36) started kidding between 25 and 40 h after the aglepristone injection. However, the goats in group A-1.5 showed a significantly (p < 0.01) higher time to parturition (mean: 46.8 h). Overall, the incidence of dystocia registered in aglepristone-induced goats (20.8%, 10/48) and luprostiol-induced goats was not different from that observed after a spontaneous parturition. The percentage of live kids was very similar between A-5, A-3.3, A.2.5 and L groups (95.7, 95.3, 95.0 and 96.3%, respectively) but was higher that observed in the control (83.4%) and A-1.5 (81.2%) groups. In addition, no maternal mortality was registered in any groups. No changes in plasma progesterone were observed during the first 24 h after treatment, and high plasma progesterone concentrations were present at kidding (6.7, 5.5, 4.5 and 3.6 ng/ml for groups A-5, A-3.3, A-2.5 and A-1.5, respectively), confirming that aglepristone does not induce parturition via luteolysis. This study demonstrates that aglepristone can be used to induce parturition in goats with satisfactory efficacy, inducing pregnancy termination without direct or immediate modifications of luteal function.

“…PGE 1 (oral, intravaginal or intracervical) has been used, concurrently, with parenterally administered prostaglandin‐F2 α (PGF 2 α ) to induce parturition in the doe and abortion in the bitch, respectively (Davidson et al. ; Alan and Tasal ). Similarly, intracervical PGE 2 and PGE 1 have been used in the mare to promote cervical ripening before induction of abortion or parturition (Volkmann and DeCramer ; Rigby et al.…”

Section: Introductionmentioning

confidence: 99%

Effects of Topical Application of Misoprostol on Cervical Relaxation in Mares

McNaughten

Pozor

Macpherson

et al. 2014

Mares who have not delivered a foal early in life may experience limitations in cervical relaxation, primarily during oestrus. A closed cervix prevents intrauterine deposition of semen during natural breeding, may delay uterine clearance after insemination leading to intrauterine fluid accumulation in, and subsequent infertility. Therefore, a reliable pharmacological method of dilating the equine cervix would have practical application in veterinary medicine. The goal of this study was to investigate the effectiveness of topically applied, synthetic prostaglandin E1 analogue (PGE1 ) for stimulating dilation of the equine cervix. Ten mares in dioestrus were randomly assigned to one of two treatments in a single-blind crossover study: (treatment) PGE1 gel (1000 mcg compounded misoprostol cream) applied topically to the external cervical os (n = 5), and (control) a vehicle cream applied topically to the external cervical os (n = 5). Transrectal palpation and ultrasonographic measurements of the cervix were performed prior to, six and 24 h post-treatment. Digital measurements were taken, per vagina, at six and 24 h post-treatment. Mares were monitored through the subsequent oestrous cycle for ovulation. Mares were assigned to the opposite treatment group such that each mare served as her own control (crossover). Data were analysed using parametric (split-plot anova), as well as nonparametric (Kruskal-Wallis anova, Wilcoxon's rank-sum test) methods. At six and 24 h there were no significant differences for tone, length, height, degree of relaxation or echotexture between control and PGE1 treated groups at the measured time points (p > 0.05). Topical cervical application of PGE1 did not induce a measurable degree of cervical relaxation under the conditions of this experiment.