Efficacy of Probiotics in Management of Celiac Disease

Abstract

The objective of this study was to interpret any rule of probiotics in the management of celiac disease and apply the results to improve the quality of life of patients with celiac disease if the result comes in favor of probiotics. Materials and methodsIt was a cross-sectional study conducted in the gastroenterology unit of Nishtar Medical University, Multan. A total of 170 children with celiac disease were enrolled in the study and divided into two groups (A and B) using a computer-generated table of random numbers. Group A was given only a gluten-free diet, while group B was given probiotics and a gluten-free diet. The efficacy of probiotics was measured in terms of reduction in stool frequency at the end of the 28 days of treatment. The data was recorded on the datasheet for every individual, and the statical analysis was performed using the Chi-square test. The patients were fully explained about the research purpose, and written consent was taken from them. ResultsThe efficacy of probiotics in children with celiac disease was compared in both groups. Results showed a marked reduction in the frequency of stools to less than half, i.e., 90.59% (n=77) in group B and 63.53% (n=54) in group A. The Chi-Square test resulted in a p-value of 0.000027 showing a significant difference in both groups. ConclusionProbiotics are found to be highly efficient in terms of reduction in diarrhea in celiac disease. Probiotics will improve not only quality of life but also play an essential role in managing celiac disease.

Replacing the Burden of the Gluten Free Diet: Then, Now, and the Future

“…lactis Bi1, Bifidobacterium breve Bbr8, and B. breve Bl10) was effective in improving the severity of IBS-type symptoms in CD patients on a strict GFD [ 48 ]. Similar results were reported in the pediatric population by Basit Ali et al Probiotics were found to be highly efficient in terms of reduction in diarrhea in CD and are useful tools to be considered in improving the quality of life among young patients with CD [ 49 ]. However, the data reported are contradictory.…”

The Effects of Probiotics on Gastrointestinal Symptoms and Microbiota in Patients with Celiac Disease: A Systematic Review and Meta-Analysis on Clinical Trials

“…No signi cant difference was reported regarding diarrhoea, constipation, abdominal pain, and vomiting after treatment. Ali et al [24] reported a signi cant higher reduction in stool frequency in probiotic arm compared to placebo after four-weeks of treatment. [17,23].…”

The effects of probiotics on gastrointestinal symptoms and microbiota in patients with celiac disease: a systematic review and meta-analysis on clinical trials

“…1). Fourteen studies [6,[15][16][17][18][19][20][21][22][23][24][25][26][27] were included in qualitative analysis and ve [19,25,15,6,17] in quantitative analysis.…”

“…Table 2 presents the characteristics of the included studies. Clinical trials were carried out in Argentina [16,20,21], Australia [15], Brazil [22], Italy [6], Pakistan [24], Slovenia [18, 19,23], Spain [17], Sweden [25,26], and Turkey [27]. Altogether, 871 participants were included in this systematic review, of whom 203 were CDA cases.…”

“…Most of the included studies were the randomized double-blinded placebo-controlled clinical trials. However, there was one clinical trial with external controls [16], one double-blinded placebo-controlled cross-over trial [21], two randomized clinical trials without any medication in placebo group [24,27], and one none-randomized clinical trial [22]. The study population of six studies consisted of adults [6,15,16,[20][21][22], while the other eight studies, including all trials on CDA, were conducted on children [17-19, 25, 23, 26, 27, 24].…”