Efficacy of Probiotics and Nutrients in Functional Gastrointestinal Disorders: A Preliminary Clinical Trial

Kim, Linda S.; Hilli, Lisa; Orlowski, Jennifer; Kupperman, Jami L.; Baral, Matthew; Waters, Robert F.

doi:10.1007/s10620-006-9297-8

Cited by 20 publications

(7 citation statements)

References 75 publications

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“…Overall, of the 13 selected studies, 11 comparisons (79%) reported probiotic benefits on the symptoms of GERD, whereas no benefit was seen in the three remaining comparisons [32][33][34]. Of the 11 former comparisons, five (45%) reported benefits for reflux symptoms, versus five (45%) for dyspepsia symptoms and nine (81%) for other upper-GI symptoms, such as nausea, abdominal pain, and gas-related symptoms (belching, gurgling, burping).…”

Section: Resultsmentioning

confidence: 99%

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Cheng

Ouwehand

2020

Nutrients

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Probiotic is little known for its benefits on upper gastrointestinal health. The objective of this systematic review was to examine the efficacy of probiotics in alleviating the frequency and severity of symptoms in gastroesophageal reflux disease (GERD) in the general adult population. The PubMed and Web of Science databases were searched for prospective studies on GERD, heartburn, regurgitation, and dyspepsia, without any limitation on sample size. The Jadad scale was used to evaluate the quality of randomized controlled trials. In total, 13 prospective studies that were published in 12 articles were included in the analysis and scored per the Jadad scale as high- (five studies), medium- (two), and low- (six) quality. One article reported on two probiotic groups; thus, 14 comparisons were included in the selected studies, of which 11 (79%) reported positive benefits of probiotics on symptoms of GERD. Five out of 11 positive outcomes (45%) noted benefits on reflux symptoms: three noted reduced regurgitation; improvements in reflux or heartburn were seen in one study; five (45%) saw improvements in dyspepsia symptoms; and nine (81%) saw improvements in other upper gastrointestinal symptoms, such as nausea (three studies), abdominal pain (five), and gas-related symptoms (four), such as belching, gurgling, and burping. In conclusion, probiotic use can be beneficial for GERD symptoms, such as regurgitation and heartburn. However, proper placebo-controlled, randomized, and double-blinded clinical trials with a sufficient number of participants are warranted to confirm its efficacy in alleviating these symptoms. Further, interventions with longer durations and an intermediate analysis of endpoints should be considered to determine the proper therapeutic window.

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Section: Resultsmentioning

confidence: 99%

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Cheng

Ouwehand

2020

Nutrients

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“…A preliminary clinical study exists which investigates the efficacy of probiotics in combination with FvA in gastrointestinal (GI) disorders [ 44 ]. Unfortunately though, all groups including ones with FvA see no improvement in Gastrointestinal Quality of Life Index (GIQLI) and Visual Analogue Scale (VAS) scores for GI symptoms.…”

Section: Gut Healthmentioning

confidence: 99%

Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes

Winkler

Ghosh

2018

Journal of Diabetes Research

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Chronic inflammatory diseases like diabetes are on a rise in the Western world. Based on the tsunami of new cases every year, new therapeutic measures must be considered. A promising avenue might involve the attenuation of underlying inflammation through natural health products (NHPs). This is because most NHPs have a rich history in traditional medicine and might be considered safer under appropriate doses and conditions. However, the biggest impediment in NHP research is that rarely do these products come with verified health benefits or dosing schedules established through modern scientific research. Fulvic acid (FvA), one such NHP, comes from humic substances produced by microorganisms in soil. Traditional medicine and modern research claim FvA can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function; all of which are hallmarks of diabetes. This minireview outlines the available peer-reviewed research on FvA and examines its anecdotal health claims. We show that although available research has been minimal, there is substantial evidence to pursue FvA research in preventing chronic inflammatory diseases, including diabetes.

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“…One of the methods for monitoring is the GIQLI questionnaire [11]. Moreover, the GIQLI has been used for nutrition and QOL assessment in colorectal cancer [12] and functional gastrointestinal disorders [13].…”

Section: Discussionmentioning

confidence: 99%

Development of the Korean Version of the Gastrointestinal Quality of Life Index Questionnaire

Yang

Lee

et al. 2022

Ann Clin Nutr Metab

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Purpose: To establish a standardized quality of life measurement that allows global cross-study comparisons, we translated the Gastrointestinal Quality of Life Index (GIQLI) into Korean and linguistically validated the Korean version of the GIQLI (K-GIQLI) in patients who underwent colorectal surgery. Materials and Methods: A cross-cultural adaptation of the original GIQLI was created based on the established guidelines. Based on participation in a cognitive interview, 20 patients with colorectal cancer were enrolled in the study. To ensure that the Korean version of the questionnaire was understood as intended, the time needed to complete the questionnaire was measured, and three additional items related to comprehension were added. Results: From May to July 2021, two translators, whose native language was Korean translated the GIQLI items into Korean, and a native English editor who had no knowledge of the original questionnaire translated the items back into English. In the cognitive interview, the median age of the patients was 61.8 (range: 44~82) years, and the median time required to complete the questionnaire was 6.5 (range: 5~10) min. For the language and cultural adaptation process, the participants' comprehension of the questionnaire was measured on a scale of 1~5, with a mean score of 4 (range: 3~4). Conclusion:The K-GIQLI was developed and did not exhibit a significant difference from the original English version in terms of social, linguistic, and cultural differences between the Western world and Republic of Korea.

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Efficacy of Probiotics and Nutrients in Functional Gastrointestinal Disorders: A Preliminary Clinical Trial

Cited by 20 publications

References 75 publications

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Gastroesophageal Reflux Disease and Probiotics: A Systematic Review

Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes

Development of the Korean Version of the Gastrointestinal Quality of Life Index Questionnaire

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