Efficacy of Preoperative and Postoperative Bone Scanning in the Management of Breast Carcinoma

Abstract

With use of 99mtechnetium-labeled phosphates, we performed preoperative bone scans on 122 women with biopsy-proved breast carcinoma. Only two of the 110 patients with Stage I or II disease had scan abnormalities interpreted as bone metastases. Of 55 patients with normal preoperative scans, 20 later had changes suggesting bone metastases on the subsequent scans, most within 24 months of operation. In women with Stage I and II tumors, 13 of 48 (27 per cent) had scan evidence of bone metastasis of postoperative follow-up examination. Five of 23 with potential surgical cures (negative lymph nodes at operation) had bone metastasis within two years of operation. In Stage I and II patients, postoperative discovery of evolving metastases was most often (11 to 13) made by bone scan. Although the initial yield from preoperative bone scans is low, preoperative scanning combined with sequential postoperative scans constitutes one of the most sensitive indicators of evolving metastatic disease.

Importance of Volumetric Measurement Processes in Oncology Imaging Trials for Screening and Evaluation of Tumors as Per Response Evaluation Criteria in Solid Tumors

“…The high incidence of skeletal metastasis in cancer patients warrants careful detection with imaging and follow-up (Gerber et al, 1977;Tarin et al, 1984).…”

“…identifying metastasis (Gerber et al, 1977) and for preoperative assessment of resectablility (Tang et al, 2013). The evaluation of tumor by measuring lesion volume with the help of a radiologist and oncologist has become a standard procedure.…”

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

“…So, the structure was assigned as 1,11-dihydroxy-8-methyl-naphthacene-5,12-dione (278) but not as 1,11-dihydroxy-9-methyl-naphthacene-5,12-dione (279). Angular quinones are excluded by the HMBC coupling of H-11 with 12-CO.…”

“…Phenazine derivatives show antibiotic properties and are characterized by their inhibitory activities against xanthine oxidase [105,279] . Phencomycin (179a) and its methyl ester (179b) were isolated from Streptomyces sp.…”

Bone Scan for Baseline Staging in Invasive Breast Cancer at the Time of Primary Presentation

“…Since its introduction into the clinical practice in the late 1960s [32,33], a large number of studies have been published on the value of BS as initial diagnostic test to detect the presence of skeletal metastases of BC at the time of primary presentation (table 1). However, the majority of these reports have suggested that the use of BS in the BC staging is of no benefit in the absence of symptoms or abnormal laboratory tests [4,5,[7][8][9][10][11][12][13][14].…”