Efficacy of photodynamic therapy combined with a guide sheath method concomitant with chemotherapy in a small-cell lung cancer patient with central endobronchial stenosis

Suzuki, Fumi; Misawa, Masafumi; Sugimura, Hiroshi; Yamawaki, Satoshi; Aoshima, Masahiro

doi:10.1016/j.pdpdt.2016.08.008

Cited by 12 publications

(5 citation statements)

References 6 publications

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“…In recent years, photodynamic therapy (PDT) has been widely applied to treat various tumors as a result of its smaller surgical trauma, better selectivity from normal tissues and capability of repeatable treatment. − In the process of PDT, the photosensitizer plays an important role in producing highly reactive singlet oxygen ( 1 O 2 ) upon photoexcitation. 1 O 2 can interact with adjacent biological macromolecules by oxidative reaction and thus lead to cell apoptosis in the targeted sites. , However, there are some barriers for PDT in the revolution of antitumor fields, including the low solubility and poor tumor targeted accumulation of the photosensitizer. Therefore, it is very necessary to improve the bioavailability of the photosensitizer to achieve desirable antitumor effects for PDT.…”

Section: Introductionmentioning

confidence: 99%

“…1 O 2 can interact with adjacent biological macromolecules by oxidative reaction and thus lead to cell apoptosis in the targeted sites. 33,34 However, there are some barriers for PDT in the revolution of antitumor fields, including the low solubility and poor tumor targeted accumulation of the photosensitizer. Therefore, it is very necessary to improve the bioavailability of the photosensitizer to achieve desirable antitumor effects for PDT.…”

Section: ■ Introductionmentioning

confidence: 99%

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Targeted Chemo-Photodynamic Combination Platform Based on the DOX Prodrug Nanoparticles for Enhanced Cancer Therapy

Zhang

Huang

Ren

et al. 2017

ACS Appl. Mater. Interfaces

123

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Chemo-photodynamic combination therapy has been received widespread attention in cancer treatment due to its excellent characteristics, such as reducing the adverse side effects of chemo-drugs and improving the therapeutic effects for various cancers. In this study, RGD and DOX was conjugated to PEG by thiol-ene addition and Schiff's base reaction, respectively, to prepare the targeted and pH-sensitive antitumor prodrug nanoparticles (RGD-PEG-DOX NPs, RGD-NPs). Subsequently, the photosensitizer chlorin e6 (Ce6) was encapsulated into RGD-NPs, thus obtaining a simple and efficient chemo-photodynamic combination platform (RGD-PEG-DOX/Ce6 NPs, RGD-NPs/Ce6). This nanoparticle possessed high drug loading property of both the chemo-drug and photosensitizer and could simultaneously release them under the mild acidic microenvironment of cancer cells, which was expected to realize the synchronization therapy of chemotherapy and photodynamic therapy (PDT). Compared with free DOX and Ce6, RGD-NPs/Ce6 could significantly improve the cellular uptake capacities of DOX and Ce6, resulting in the increased contents of ROS in cancer cells and effective cytotoxicity for tumor cells (MDA-MB-231 cells and MCF-7 cells) upon a laser radiation. The in vivo experiment showed that RGD-NPs/Ce6 displayed superior tumor targeting, accumulation, and retention ability than the other groups (free DOX, free Ce6 and NPs/Ce6), and thus significantly enhancing the antitumor effect in vivo with a laser radiation. In addition, the cardiotoxicity induced by DOX was thoroughly wiped out after being loaded and delivered by the nanoparticles according to the pathological analysis. Therefore, the targeted chemo-photodynamic combination therapeutic platform may be a promising candidate for enhanced cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Targeted Chemo-Photodynamic Combination Platform Based on the DOX Prodrug Nanoparticles for Enhanced Cancer Therapy

Zhang

Huang

Ren

et al. 2017

ACS Appl. Mater. Interfaces

123

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“…There is no evidence of differences in PDT efficacy among other types of NSCLC. Additionally, patients with SCLC may also benefit from PDT similarly to those with NSCLC, suggesting that these patients should not be excluded from PDT simply based on cancer type [53,61].…”

Section: Does Tumor Morphology or Histopathology Affect The Therapeut...mentioning

confidence: 99%

Clinical Practice of Photodynamic Therapy for Non-Small Cell Lung Cancer in Different Scenarios: Who Is the Better Candidate?

Sun,

Zhang,

Wang

et al. 2024

Respiration

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Background: Photodynamic therapy (PDT) is a relatively safe and highly selectivity anti-tumor treatment, which might be increasingly used as a supplement to conventional therapies. A clinical overview and detailed comparison of how to select patients and lesions for PDT in different scenarios is urgently needed to provide a basis for clinical treatment. Summary: This review demonstrates the highlights and obstacles of applying PDT for lung cancer, and underlines points worth considering when planning to initiate PDT. The aim is to make out the appropriate selection and help PDT develop efficacy and precision through a better understanding of its clinical use. Key Messages: ● Increasing evidence supports the feasibility and safety of Photodynamic therapy (PDT) in the treatment of NSCLC. ● It is important to recognize the factors that influence the efficacy of PDT to develop individualized management strategies and implement well-designed procedures. ● These important issues should be worth considering in the present and further research.

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“…Photodynamic therapy (PDT) combined with chemotherapy for cancer treatment has been intensively concerned on account of their enhanced curative effect and lesser side effects [1][2][3][4][5]. In PDT, a photosensitizer, which is an essential chemical, can obtain enough energy from laser and convert it to heat that induces cancer cell apoptosis and death [6].…”

Section: Introductionmentioning

confidence: 99%

A pH-Responsive Multifunctional Nanocarrier in the Application of Chemo-Photodynamic Therapy

Gao

Tan

et al. 2019

Journal of Nanomaterials

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In cancer therapy, combined utilization of anticancer drug and photosensitizer attracts increasing interest due to enhanced curative effects and reduced side effects. Since the drug delivery system is an effective method to enhance curative effects, drug carriers for codelivery of the two abovementioned molecules are essentially important for chemophotodynamic therapy. Based on the foundation, a nanocarrier with pH-responsive and targeted properties was designed, prepared, and researched in the work. A pH-sensitive nanoparticle was fabricated by acetylated β-cyclodextrin (Ac-β-CD) using oil-in-water (O/W) emulsion technique. During the fabrication processing, a functional emulgator (gelation-folic acid ester (G-FA)) with a biorecognition domain was absorbed onto the surface of the nanoparticle, which endowed a nanoparticle-targeted property. The nanoparticle exhibited a coarse surface, pH-responsive property, and similar fluorescence characteristic as G-FA. The cell endocytosis profile revealed that equilibrium endocytosis could be reached after being cocultured with 1.0 mg/mL nanoparticle for 8 h. Furthermore, camptothecin (CPT) as an anticancer drug and phthalocyanine (PcZn) as a photosensitizer were encapsulated into the nanoparticle during the fabrication processing. The nanoparticle enhanced the fluorescence effects of PcZn on water solution, and CPT encapsulation proportion was slightly influenced by initial CPT concentration. The pH value influenced the PcZn fluorescence behavior and CPT release behavior of the nanoparticle. In vitro cytoviability evaluation confirmed the therapeutic effect of the nanocarrier on HEP2 cells. Finally, the results of preliminary in vivo evaluation revealed that the reported nanocarrier in the research could inhibit cancer development with little effects on the body weight of mice.

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Efficacy of photodynamic therapy combined with a guide sheath method concomitant with chemotherapy in a small-cell lung cancer patient with central endobronchial stenosis

Cited by 12 publications

References 6 publications

Targeted Chemo-Photodynamic Combination Platform Based on the DOX Prodrug Nanoparticles for Enhanced Cancer Therapy

Targeted Chemo-Photodynamic Combination Platform Based on the DOX Prodrug Nanoparticles for Enhanced Cancer Therapy

Clinical Practice of Photodynamic Therapy for Non-Small Cell Lung Cancer in Different Scenarios: Who Is the Better Candidate?

A pH-Responsive Multifunctional Nanocarrier in the Application of Chemo-Photodynamic Therapy

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