Efficacy of oropharyngeal lidocaine instillation on hemodynamic responses to orotracheal intubation

Sun, Hsiao-Lun; Wu, Tzong-Jeng; Ng, Chen-Chuan; Chien, Chih Cheng; Huang, Chi‐Cheng; Chie, Wei‐Chu

doi:10.1016/j.jclinane.2008.06.028

Cited by 17 publications

(11 citation statements)

References 25 publications

(26 reference statements)

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“…In addition, sudden hemodynamic changes may lead to serious complications, especially in patients with a comorbid disease like hypertension [ 3 ]. Accordingly, anesthesiologists have devised means of attenuating the sympathetic stimulation in order to decrease the incidences of perioperative complications by using drugs, including opioids, adrenergic blockers, vasodilators, calcium channel blockers, lidocaine, and inhaled anesthetics [ 9 10 11 12 13 14 15 ]. Although many reports claim various drugs effectively attenuate hemodynamic responses, they also mention unexpected side effects like hypoventilation, hypotension, bradycardia, and muscle rigidity [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of preanesthetic dexmedetomidine on hemodynamic responses to endotracheal intubation in elderly patients undergoing treatment for hypertension: a randomized, double-blinded trial

Lee

Kim

2017

Korean J Anesthesiol

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BackgroundDexmedetomidine is an alpha-2 adrenergic agonist with sedative, anxiolytic, and analgesic properties. This study was designed to evaluate the inhibitory effects of preoperative administration of 0.5 µg/kg dexmedetomidine on hemodynamic responses caused by endotracheal intubation in elderly patients undergoing treatment for hypertension.MethodsForty elderly (≥ 65 years old) patients who had been receiving hypertension treatment, had American Society of Anesthesiologists physical status II, and were scheduled to undergo elective noncardiac surgery were randomly selected and assigned to 2 groups. Group C received normal saline and group D received 0.5 µg/kg dexmedetomidine intravenously over 10 min just before endotracheal intubation. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) were recorded preoperatively in the ward, immediately after study drug administration, and at 1, 3, and 5 min after endotracheal intubation.ResultsCompared to group C, group D showed significantly lower SBP and MAP at 1, 3, and 5 min as well as significantly lower DBP and HR at 3 and 5 min after endotracheal intubation.ConclusionsIn elderly patients receiving hypertension treatment, a single preanesthetic dose of dexmedetomidine (0.5 µg/kg) effectively suppressed the hemodynamic responses to endotracheal intubation.

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Section: Discussionmentioning

confidence: 99%

Effects of preanesthetic dexmedetomidine on hemodynamic responses to endotracheal intubation in elderly patients undergoing treatment for hypertension: a randomized, double-blinded trial

Lee

Kim

2017

Korean J Anesthesiol

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“…1 Although bronchospasm, intracranial and intraocular pressure elevation, hypertension, tachycardia, arrhythmia, and especially hemodynamic alterations occur transiently, the responses can be deleterious to patients with diseases of the cardio-/cerebrovascular and endocrine systems. 2,3 Various therapeutic medications and methods have been employed to reduce or suppress cardiovascular responses caused by endotracheal intubation, 4 including local anesthesia, 5 intravenous lidocaine, 6 drugs affecting adrenergic receptors (eg, b-adrenoceptor antagonists, 7 a 1 -and a 2 -adrenocepter agonists 8 ), vasoactive agents (eg, glyceryl trinitrate, 9 calcium channel blockers, 10 sodium nitroprusside 11 ), and a laryngeal mask. 12 However, the optimal medicine or method to avoid stress responses in these patients has not been unequivocally established.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Low-dose and High-dose Pregabalin and Cardiovascular Response to Endotracheal Intubation: A Prospective, Randomized, Single-blind, Controlled Study in China

Chen

Huang

Chuanxin

et al. 2019

Clinical Therapeutics

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“…Tracheal intubation is among the safest, commonest methods for maintaining an open airway. Cardiovascular complications such as hypertension are the most important complications which may be tolerated by the healthy subjects but can result in ischemia and cardiac failure in patients with impaired or limited coronary/cardiovascular capacity ( 3 , 4 ). Considering the characteristics of elderly patients, it is really important to stabilize the hemodynamic status of these patients ( 2 , 8 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic Responses to Tracheal Intubation in Elderly Patients: Intravenous or Spray of Lidocaine versus Fentanyl

et al. 2017

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IntroductionLaryngoscopy and tracheal intubation are known to increase sympathetic activity that may be detrimental to patients with preexisting ischaemic or hypertensive heart disease.AimThe aim of this study was to compare of intravenous and oropharyngeal spray of lidocaine and high dose of fentanyl on systolic and diastolic blood pressures and heart rate of patients over 65 years during tracheal intubation.Material and MethodsIn this clinical trial, 160 patients over 65 yrs who were randomly divided into five groups of 32 patients. For group one lidocaine spray 10%, group two intravenous lidocaine 1.5 mg/kg, group three lidocaine spray along with intravenous lidocaine 0.75 mg/kg, and for group four fentanyl 5μg/kg were administered and group five patients were controls which were given 1 mg of midazolam along with 2 μg/kg fentanyl. Systolic and diastolic blood pressures and heart rate were measured before and after anesthesia and intubation. ANOVA, Scheffe’s and Repeated measure tests were used for data comparison and P<0.05 was considered significant.ResultsNo significant difference was detected in terms of gender among the understudy groups. The mean (SD) age of patients in all groups were 69 ±3.5 yrs. (65-80 yrs.) and there is no significant difference was detected between the mean age and other basic variables of under study groups (P<0.328). Study results showed that the kind of surgery hasn’t different between groups. The table showed that no difference between male and female. No significant difference was observed between groups with different sizes of tracheal tube in terms of systolic and diastolic blood pressures and heart rate. No significant difference was detected in terms of systolic and diastolic blood pressures and heart rate among groups prior to the induction of anesthesia.ConclusionAll methods were effective for efficient blood pressure control during laryngoscopy and tracheal intubation.

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Efficacy of oropharyngeal lidocaine instillation on hemodynamic responses to orotracheal intubation

Cited by 17 publications

References 25 publications

Effects of preanesthetic dexmedetomidine on hemodynamic responses to endotracheal intubation in elderly patients undergoing treatment for hypertension: a randomized, double-blinded trial

Effects of preanesthetic dexmedetomidine on hemodynamic responses to endotracheal intubation in elderly patients undergoing treatment for hypertension: a randomized, double-blinded trial

Preoperative Low-dose and High-dose Pregabalin and Cardiovascular Response to Endotracheal Intubation: A Prospective, Randomized, Single-blind, Controlled Study in China

Hemodynamic Responses to Tracheal Intubation in Elderly Patients: Intravenous or Spray of Lidocaine versus Fentanyl

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