Efficacy of Oral Administration of Sodium Iodide to Prevent Bovine Respiratory Disease Complex

Shoemake, Brian M.; Ley, B. L. Vander; Newcomer, Benjamin W.; Heller, Meera C.

doi:10.1111/jvim.14903

Cited by 9 publications

(14 citation statements)

References 17 publications

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“…Even after a single dose of 70 mg NaI, iodide levels did not achieve baseline even on day 3. At the same time, the effectiveness of the action of iodides was against Mannheimia haemolytica and Bibersteinia trehalosi insignificant at concentrations of 500 μM and below [19]. Only when combined with an antibiotic is a significant effect achieved.…”

Section: Resultsmentioning

confidence: 87%

The efficacy of combination the amoxicillin and new complex of iodine for lungs infection of mice caused by Klebsiella pneumonia

Islamov¹,

Поминова

Myrzabayeva

et al. 2021

IJBCh

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In this work, the effectiveness of combination therapy of a new iodine complex (PA) and amoxicillin was investigated. For this, an experimental model of mouse lung infection caused by multiresistant Klebsiella pneumonia ATCC 700603 strain was used. Therapy was administered for 14 days with amoxicillin at a dose of 10 mg/kg and PA at doses of 20 and 200 mg/kg. In addition, the post-therapeutic effect was assessed on day 7. The level of bacteria was studied in the lungs and blood. The concentration of antibiotic and PA in blood was also measured. As a result, it was found that on day 14 the level of bacteria in the lungs and blood significantly decreased with a combination of 10 mg/kg amoxicillin and 200 mg/ kg PA. 7 days after the completion of therapy, complete elimination of bacteria occurred in the groups of 20 and 200 mg/kg PA in combination with an antibiotic. With the combined effect of PA and amoxcillin, the level of the antibiotic increases, this may indicate an improvement in bioavailability. These results demonstrate the effectiveness of PA in combination with amoxicillin.

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Section: Resultsmentioning

confidence: 87%

The efficacy of combination the amoxicillin and new complex of iodine for lungs infection of mice caused by Klebsiella pneumonia

Islamov¹,

Поминова

Myrzabayeva

et al. 2021

IJBCh

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“…The antimicrobial effects of hypohalous acids such as HOI on enveloped viruses is variable and unpredictable. Although the few in vivo experiments of iodine supplementation in sheep or cattle infected with respiratory viruses have yielded promising results, the pathogenic microorganisms tested did not include coronaviruses 5,30,31 . Patel et al measured a K i of ~10 µM for in uenza viruses for HOI generated in vitro 6 .…”

Section: Discussionmentioning

confidence: 99%

Excess Iodine Exposure Acutely Increases Salivary Iodide And Antimicrobial Hypoiodous Acid Concentrations In Humans

Akiba¹,

Leung

Bashir

et al. 2021

Preprint

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The lactoperoxidase (LPO)-hydrogen peroxide-halides reaction (LPO system) converts iodide and thiocyanate (SCN-) into hypoiodous acid (HOI) and hypothiocyanite (OSCN-), respectively. Since this system has been implicated in defense of the airways and oropharynx from microbial invasion, we measured the concentrations of these analytes in human saliva before and after iodine administration to test the hypothesis that an iodide load increases salivary iodide and HOI concentrations. Salivary iodide, SCN-, HOI and OSCN- were measured using standard methodology. Salivary iodide and HOI levels significantly increased after iodinated contrast injection compared with baseline levels, whereas there was no significant change in salivary SCN- and OSCN- levels. The contrast dye iodine load and changes of salivary iodide and HOI levels were positively correlated, suggesting that higher iodide in the circulation increases iodide output and salivary HOI production. Excess iodine exposure in humans increases the salivary output of iodide, increasing salivary HOI concentrations with no effect on SCN-/OSCN- levels. This first of its kind study suggests that a sufficient but safe iodide supplementation may augment the generation of antimicrobial HOI by the salivary LPO system against airborne viral pathogens, including coronaviruses and influenza viruses, a possible inexpensive means of effectively curbing viral pandemics.

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“…However, experimentally, the substitution of SCN − by I − increases the innate antiviral defences of the respiratory mucosa against adenoviruses and the respiratory syncytial virus ( 81 ). Oral administration of KI vs. NaI increases iodemia, allowing for the accumulation of I − in the mucous secretions of the upper respiratory tract in humans ( 81 ) as well as animals ( 82 , 83 ). Although it has already been demonstrated that I − accumulates in submandibular glands in hamsters ( 84 ), no similar observations have been reported in humans.…”

Section: Oxidant Production By Oral Peroxidasesmentioning

confidence: 99%

Oral peroxidases: From antimicrobial agents to ecological actors (Review)

Courtois

2021

Mol Med Rep

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Sialoperoxidase and myeloperoxidase are the two main peroxidase enzymes found in the oral cavity. Sialoperoxidase is present in salivary secretions and in the biofilms that line the oral surfaces, while myeloperoxidase is abundant in the dento-gingival sulcus area. In the presence of hydrogen peroxide (H 2 O 2 ), oral peroxidases catalyze the oxidation of the pseudohalide anion thiocyanate (SCN − ) to hypothiocyanite (OSCN − ), a strong oxidant that serves an antimicrobial role. Furthermore, oral peroxidases consume bacteria-produced H 2 O 2 and could help inactivate toxic carcinogenic and genotoxic substances. Numerous in vitro studies have reported the antibacterial, antimycotic and antiviral role of peroxidases, suggesting possible applications in oral therapy. However, the use of oral hygiene products incorporating peroxidase systems has not yet been shown to be beneficial for the treatment or prevention of oral infections. This paradox reflects our incomplete knowledge of the physiological role of peroxidases in a complex environment, such as the oral region. While hygiene is crucial for restoring oral microbiota to a symbiotic state, there are no data to suggest that the addition of a peroxidase per se can create a dysbiotic state. Recent investigations have associated the presence of peroxidase activity with gram-positive cocci microbial flora, and its insufficiency with dysbiosis has been linked to pathologies, such as caries, periodontitis or infections of the oral mucosa. Therefore, oxidants generated by oral peroxidases appear to be an essential ecological determinant for oral health through the selection of a symbiotic microbiota capable of resisting oxidative stress. The objective of the present review was to update the current knowledge of the physiological aspects and applications of oral peroxidases in clinical practice.

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Efficacy of Oral Administration of Sodium Iodide to Prevent Bovine Respiratory Disease Complex

Cited by 9 publications

References 17 publications

The efficacy of combination the amoxicillin and new complex of iodine for lungs infection of mice caused by Klebsiella pneumonia

The efficacy of combination the amoxicillin and new complex of iodine for lungs infection of mice caused by Klebsiella pneumonia

Excess Iodine Exposure Acutely Increases Salivary Iodide And Antimicrobial Hypoiodous Acid Concentrations In Humans

Oral peroxidases: From antimicrobial agents to ecological actors (Review)

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