Efficacy of Omeprazole Paste in the Prevention of Gastric Ulcers in 2 Years Old Thoroughbreds

Endo, Yoshiro; Tsuchiya, Tomonori; Sato, Fumio; Murase, Harutaka; Omura, Takaya; Korosue, Kenji; Nambo, Yasuo; Ishimaru, Mutsuki; Wakui, Yasuhiro

doi:10.1292/jvms.11-0545

Cited by 11 publications

(15 citation statements)

References 16 publications

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“…The quality of the seven included studies was good, with only three studies having some methodological flaws . Overall, the risk of bias was low (Figs and ).…”

Section: Resultsmentioning

confidence: 92%

Prophylactic therapy with omeprazole for prevention of equine gastric ulcer syndrome (EGUS) in horses in active training: A meta‐analysis

Mason

Moroney

Mason³

2018

Equine Veterinary Journal

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“…The quality of the seven included studies was good, with only three studies having some methodological flaws . Overall, the risk of bias was low (Figs and ).…”

Section: Resultsmentioning

confidence: 92%

Prophylactic therapy with omeprazole for prevention of equine gastric ulcer syndrome (EGUS) in horses in active training: A meta‐analysis

Mason

Moroney

Mason³

2018

Equine Veterinary Journal

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“…; Endo et al . ), although 0.5 mg/kg bwt per os s.i.d. of an enteric‐coated formulation (Gastrozol) 2 has recently been shown to be as effective under specific conditions (Sykes et al .…”

Section: Preventionmentioning

confidence: 92%

“…It is typically used at 1.0 mg/kg bwt per os s.i.d. using buffered formulations (McClure et al 2005b;Endo et al 2012), although 0.5 mg/kg bwt per os s.i.d. of an enteric-coated formulation (Gastrozol) 2 has recently been shown to be as effective under specific conditions (Sykes et al 2014a).…”

Section: Preventionmentioning

confidence: 99%

Rethinking equine gastric ulcer syndrome: Part 2 – Equine squamous gastric ulcer syndrome (ESGUS)

Sykes¹,

Jokisalo

2015

Equine Veterinary Education

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Summary It has recently been highlighted that significant differences in prevalence, risk factors and the response to treatment exist between ulceration of the squamous gastric mucosa and ulceration of the glandular gastric mucosa in the horse. In the first article in the series, the term equine squamous gastric ulcer syndrome (ESGUS) was used to describe disease of the squamous gastric mucosa with clinical signs and diagnosis discussed. The purpose of this article is to review the pathophysiology, risk factors, prevalence, treatment and prevention of ESGUS.

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“…The importance of acid secretion to ulceration is suggested by the effectiveness of histamine receptor 2 (H 2 ) antagonists [21,22] and proton pump inhibitors [22][23][24][25][26][27] in treatment. Benefit has also been found from administration of sulcrafate, a combination of sucrose, sulphate and aluminium; this inhibits pepsin and increases prostaglandin levels, although the protection against ulceration probably derives mainly from an increased production of mucin [28].…”

Section: Horsesmentioning

confidence: 99%

Peptic Ulcer and Exercise

Shephard

2016

Sports Med

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Relationships between peptic ulcer and physical activity have as yet received little attention. The prevalence of ulceration is high in racehorses and sled dogs, particularly during periods of competition. In humans, some occupational comparisons show an increased risk among manual workers, but it remains difficult to separate effects of work-related activity from social class and attendant influences of smoking, excessive alcohol consumption, shift work, and other stressors. Two studies of leisure activity point to some benefit from moderate physical activity, one finding a reduced risk of gastric ulcers and the other finding no effect on gastric ulcers but a reduced risk of duodenal ulcers in men only. Moderate physical activity could have a favorable impact on a number of risk factors for peptic ulceration. It could reduce gastric secretions and enhance immune function, with the latter reducing the risk of Helicobacter pylori infection. Moderate activity might also reduce anxiety and encourage the adoption of a healthy lifestyle, with avoidance of smoking and an excessive consumption of alcohol. However, prolonged endurance exercise seems likely to have a negative impact, suppressing immune function, reducing mucosal blood flow, and calling for frequent administration of non-steroidal anti-inflammatory drugs (NSAIDs). As with other aspects of exercise medicine, there may be a J-shaped relationship between dose and response. Limited human observations suggest a favourable response to bouts of moderate leisure activity but little benefit from heavy occupational activity and, in some animal studies, negative effects at high volumes and intensities of exercise. Further research is recommended to confirm the nature of this relationship, clarify the location of any nadir of risk for various classes of individual, and to explore mechanisms and antidotes.

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Efficacy of Omeprazole Paste in the Prevention of Gastric Ulcers in 2 Years Old Thoroughbreds

Cited by 11 publications

References 16 publications

Prophylactic therapy with omeprazole for prevention of equine gastric ulcer syndrome (EGUS) in horses in active training: A meta‐analysis

Prophylactic therapy with omeprazole for prevention of equine gastric ulcer syndrome (EGUS) in horses in active training: A meta‐analysis

Rethinking equine gastric ulcer syndrome: Part 2 – Equine squamous gastric ulcer syndrome (ESGUS)

Peptic Ulcer and Exercise

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